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The map label for this gene is moeA [H]

Identifier: 124027030

GI number: 124027030

Start: 113934

End: 115199

Strand: Reverse

Name: moeA [H]

Synonym: Hbut_0130

Alternate gene names: 124027030

Gene position: 115199-113934 (Counterclockwise)

Preceding gene: 124027031

Following gene: 124027028

Centisome position: 6.91

GC content: 55.69

Gene sequence:

>1266_bases
TTGCAGAAGGTTCCACGTTACCTGGAGAAGCTCACACCAGTCGAAGAAGCCGTTAAGGCGATAATGGAGGCTGTGAAGCC
AGTAGCGGAGGAGGAACTCGTCGACACGTGGACTGCTGTCGGCAGGGTCTTGTCAAGGGATGTTGTTGCAGCCTATGATT
TTCCCCCGAGGCCACGTTCCGCCTATGACGGCTATGCTGTGCGTTCCGGAGATACTCCTGGCAGGCTTCGCCTCCTTGGC
GAGGCTACGATAGGCCGGGTCGACGTTGAGTACCGTGTTGAGCCGGGTACAGCTGTTTACGTCTCCACGGGTGCTTACCT
ACCCGATGGTGCTGACACTGTTGTGCCTGAGGAGAAGGCTAGGAGGGAGAACGGCTATATCATCGTCGAGAAGCATTACC
CGCCAGGCAAGAACCTTGACCCAGTTGGGGCCTATGCGCGCCGTGGGCAAGTCCTATTACCAAAGGGCTATGTTGTCACT
ATGCTTGATGCTGTTGGTCTCCTAGATGTTGCTGTTACCAGGATCTATGTCTATCGTAGGGTTAGGCTAGCAATGATACT
TACTGGCAACGAGATATTCGAACTCCGCAATCCCATGGAGGCTGAGGAGAGAGTCCTTAGGGGCGAGGTTGTAGAGTCTA
CTGGGAGGCTCATAGAGTGGGCTATCCGCCGCTACACGCCCTGGGTGGAAGTTCTCGGCCGTGTACTATTACCTGATGAC
GTTGACACCATAGCCTGGTATGTAACTAGGCAGTTCCGCAATGCAGACGTCATAGTTATGACGGGTGGCTCAGGCCCCAG
CACTGTGGACACGTTCTACCAGCTGGCGGAAAGGCTTGGGGGCCGGGTGCTGTTCCGGGGCCTATACGTTAAAGGTGGTA
GGCCAACCTCAGCGCTAAAGCTCGACAAGGGACCGTTACTGATCGTACTATCGGGGCACCCTATATCGGCGCTGCATGGT
TTTGTGAGGGTGCTCTACCCGGTGCTGAAGTATCTTGGCAACGTTGTTCGTGCAGCTGAGCCGCCAGCTTTCGCCTATGC
GGTGCTTGAAGAGGGTGGTGAGTACAAGAGGCCGCAGCCGGTAAAGGTTAAGCTGATATTACGTGACGGTGTACTCTACG
CTAAGCCCCTGCCGGGTGAGAGGCAGCTAAGCTCGGTGACAGTTAGCAATGTTGAGGCTGACGGTATAGCGTTGGTTGAG
GGTCGCAGGTATAATGCCGGGGAGCGTGTGCCGGTGATAGTTTACCGTGAGCCCTCTACCGGCTAA

Upstream 100 bases:

>100_bases
CTGTTGGTTCCGTCACTAGCTCTGTAGGGGCTAGTATCACTAACCCCTCTCCAGGCGGGAGGAGAGGCGGAGCACCCTGC
ACGGGGGGCGTGGCTGGGTC

Downstream 100 bases:

>100_bases
CGCTCTGTATCGCCTTGAGGATTTTTTTAGCCATACCTACTGGATCCCTACTCCTCGTTATTGCGCCGCCGACAATGGCT
ATCGATGCCCCTGCCTCAAT

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQKVPRYLEKLTPVEEAVKAIMEAVKPVAEEELVDTWTAVGRVLSRDVVAAYDFPPRPRSAYDGYAVRSGDTPGRLRLLG
EATIGRVDVEYRVEPGTAVYVSTGAYLPDGADTVVPEEKARRENGYIIVEKHYPPGKNLDPVGAYARRGQVLLPKGYVVT
MLDAVGLLDVAVTRIYVYRRVRLAMILTGNEIFELRNPMEAEERVLRGEVVESTGRLIEWAIRRYTPWVEVLGRVLLPDD
VDTIAWYVTRQFRNADVIVMTGGSGPSTVDTFYQLAERLGGRVLFRGLYVKGGRPTSALKLDKGPLLIVLSGHPISALHG
FVRVLYPVLKYLGNVVRAAEPPAFAYAVLEEGGEYKRPQPVKVKLILRDGVLYAKPLPGERQLSSVTVSNVEADGIALVE
GRRYNAGERVPVIVYREPSTG

Sequences:

>Translated_421_residues
MQKVPRYLEKLTPVEEAVKAIMEAVKPVAEEELVDTWTAVGRVLSRDVVAAYDFPPRPRSAYDGYAVRSGDTPGRLRLLG
EATIGRVDVEYRVEPGTAVYVSTGAYLPDGADTVVPEEKARRENGYIIVEKHYPPGKNLDPVGAYARRGQVLLPKGYVVT
MLDAVGLLDVAVTRIYVYRRVRLAMILTGNEIFELRNPMEAEERVLRGEVVESTGRLIEWAIRRYTPWVEVLGRVLLPDD
VDTIAWYVTRQFRNADVIVMTGGSGPSTVDTFYQLAERLGGRVLFRGLYVKGGRPTSALKLDKGPLLIVLSGHPISALHG
FVRVLYPVLKYLGNVVRAAEPPAFAYAVLEEGGEYKRPQPVKVKLILRDGVLYAKPLPGERQLSSVTVSNVEADGIALVE
GRRYNAGERVPVIVYREPSTG
>Mature_421_residues
MQKVPRYLEKLTPVEEAVKAIMEAVKPVAEEELVDTWTAVGRVLSRDVVAAYDFPPRPRSAYDGYAVRSGDTPGRLRLLG
EATIGRVDVEYRVEPGTAVYVSTGAYLPDGADTVVPEEKARRENGYIIVEKHYPPGKNLDPVGAYARRGQVLLPKGYVVT
MLDAVGLLDVAVTRIYVYRRVRLAMILTGNEIFELRNPMEAEERVLRGEVVESTGRLIEWAIRRYTPWVEVLGRVLLPDD
VDTIAWYVTRQFRNADVIVMTGGSGPSTVDTFYQLAERLGGRVLFRGLYVKGGRPTSALKLDKGPLLIVLSGHPISALHG
FVRVLYPVLKYLGNVVRAAEPPAFAYAVLEEGGEYKRPQPVKVKLILRDGVLYAKPLPGERQLSSVTVSNVEADGIALVE
GRRYNAGERVPVIVYREPSTG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=428, Percent_Identity=28.7383177570093, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI66932975, Length=428, Percent_Identity=28.7383177570093, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1787049, Length=339, Percent_Identity=25.0737463126844, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25147659, Length=372, Percent_Identity=26.3440860215054, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562606, Length=170, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136978, Length=426, Percent_Identity=24.4131455399061, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24638841, Length=426, Percent_Identity=24.4131455399061, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46617; Mature: 46617

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVPRYLEKLTPVEEAVKAIMEAVKPVAEEELVDTWTAVGRVLSRDVVAAYDFPPRPRS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
AYDGYAVRSGDTPGRLRLLGEATIGRVDVEYRVEPGTAVYVSTGAYLPDGADTVVPEEKA
CCCCEEEECCCCCCEEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHH
RRENGYIIVEKHYPPGKNLDPVGAYARRGQVLLPKGYVVTMLDAVGLLDVAVTRIYVYRR
HCCCCEEEEEECCCCCCCCCCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRLAMILTGNEIFELRNPMEAEERVLRGEVVESTGRLIEWAIRRYTPWVEVLGRVLLPDD
EEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
VDTIAWYVTRQFRNADVIVMTGGSGPSTVDTFYQLAERLGGRVLFRGLYVKGGRPTSALK
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEE
LDKGPLLIVLSGHPISALHGFVRVLYPVLKYLGNVVRAAEPPAFAYAVLEEGGEYKRPQP
ECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
VKVKLILRDGVLYAKPLPGERQLSSVTVSNVEADGIALVEGRRYNAGERVPVIVYREPST
EEEEEEEECCEEEECCCCCCCHHHEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCC
G
C
>Mature Secondary Structure
MQKVPRYLEKLTPVEEAVKAIMEAVKPVAEEELVDTWTAVGRVLSRDVVAAYDFPPRPRS
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
AYDGYAVRSGDTPGRLRLLGEATIGRVDVEYRVEPGTAVYVSTGAYLPDGADTVVPEEKA
CCCCEEEECCCCCCEEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHH
RRENGYIIVEKHYPPGKNLDPVGAYARRGQVLLPKGYVVTMLDAVGLLDVAVTRIYVYRR
HCCCCEEEEEECCCCCCCCCCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VRLAMILTGNEIFELRNPMEAEERVLRGEVVESTGRLIEWAIRRYTPWVEVLGRVLLPDD
EEEEEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
VDTIAWYVTRQFRNADVIVMTGGSGPSTVDTFYQLAERLGGRVLFRGLYVKGGRPTSALK
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEE
LDKGPLLIVLSGHPISALHGFVRVLYPVLKYLGNVVRAAEPPAFAYAVLEEGGEYKRPQP
ECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
VKVKLILRDGVLYAKPLPGERQLSSVTVSNVEADGIALVEGRRYNAGERVPVIVYREPST
EEEEEEEECCEEEECCCCCCCHHHEEEEECCCCCCEEEEECCCCCCCCCCEEEEEECCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]