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The map label for this gene is cysK [H]

Identifier: 124027013

GI number: 124027013

Start: 100846

End: 101826

Strand: Direct

Name: cysK [H]

Synonym: Hbut_0113

Alternate gene names: 124027013

Gene position: 100846-101826 (Clockwise)

Preceding gene: 124027006

Following gene: 124027014

Centisome position: 6.05

GC content: 54.43

Gene sequence:

>981_bases
ATGGTTCTAGCCTCTAAACCCTCTAGCCGCGAAGAACTCCTCCAAGCCATAGAGAGGCTTTCGCGTATCGTAGGGGGTAC
TCCAACTAAATGCTTTACCCTGGGCTCATATAGGTTCTGTGTAAAGCTGGAATACGTAAACCCGGCAGGGAGCCACAAGG
ACCGCATAGCCCTTTACATGATTAAAGGTGCTATAGAGTCTGGCGCTGTGGACCCCGGGGGCTGTGTTGCCGAGGTTAGC
AGCGGCAATACGGCAACATCGGTTGCGTGGATTGCACACCTCCTAGGCCTCCGCTCGGTGCTATTTGTCGAAAAGACGGC
ATCGGCGGTTAAGAAGAAGCTTATCAGAATGTTTGGCGGTGAAATAGTTGAGGTGACCACTGAGGGGAGTGGCCGCGAGA
GGGCTAGAGAGGAGATAGCCCAGATGGGCTGCTTCTTCCTCGACCAGATGGCCAACGAGATGAACCATTTAGCTCACTAC
GAGACAACGGCGAGCGAGCTGCTCTCCCAGGTTAAGCATGTGGACGCATTCGTCATGGGCGTTGGCACAGCCGGCACAGT
GACCGGCGTTGGCAGGAGACTTAAGGAGACCCTAGGCAATACACTAAACGTGGCCGTGACTCCGAAAGGCTCAGCACTCG
CTGGAGGCCGAGGCGAAGACCATATAGAGGGCCTAGTGAGCGACTTCGTACCCGATATCTACTCCAGGTATAGCAGATAC
GTTGACCGCGTAGTAGAGGTTTCATCCTCCGAGGCTATAATCGGTATAGCCGCGCTACTACGCGCGACAGGTCTACTGGC
AGGCCCGTCAACCGGTGCAGCATTTGTAGCAGCAACAAGGCTCGTAGAGTGTGGAGCACTAGACAGGGGCTCAACGATAG
TCATAGTGGCTGCAGACCACCTATCAAGATACCCTGACATAATCGCGAAGATAAAACCGCACTCGCCGCAAGTAGACGAA
CTCCTTAAAGCTTGGCAGTAG

Upstream 100 bases:

>100_bases
AGGAAACATTACACAAAGGTTACATTTATTAATGTAGTTTGTGCGAGAGCGCTAATAGCCGGACACTATATGCGTAACCG
CCTCTCCTGGGTGTCCGAAA

Downstream 100 bases:

>100_bases
CTGTAGCCACCCCACCGGGCAGCACATGACAAAATACATCTTTGTCACGGGCGGAGTCCTCAGCAGCGTTGGCAAAGGTA
TAACTACAGCCTCTATAGGC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MVLASKPSSREELLQAIERLSRIVGGTPTKCFTLGSYRFCVKLEYVNPAGSHKDRIALYMIKGAIESGAVDPGGCVAEVS
SGNTATSVAWIAHLLGLRSVLFVEKTASAVKKKLIRMFGGEIVEVTTEGSGRERAREEIAQMGCFFLDQMANEMNHLAHY
ETTASELLSQVKHVDAFVMGVGTAGTVTGVGRRLKETLGNTLNVAVTPKGSALAGGRGEDHIEGLVSDFVPDIYSRYSRY
VDRVVEVSSSEAIIGIAALLRATGLLAGPSTGAAFVAATRLVECGALDRGSTIVIVAADHLSRYPDIIAKIKPHSPQVDE
LLKAWQ

Sequences:

>Translated_326_residues
MVLASKPSSREELLQAIERLSRIVGGTPTKCFTLGSYRFCVKLEYVNPAGSHKDRIALYMIKGAIESGAVDPGGCVAEVS
SGNTATSVAWIAHLLGLRSVLFVEKTASAVKKKLIRMFGGEIVEVTTEGSGRERAREEIAQMGCFFLDQMANEMNHLAHY
ETTASELLSQVKHVDAFVMGVGTAGTVTGVGRRLKETLGNTLNVAVTPKGSALAGGRGEDHIEGLVSDFVPDIYSRYSRY
VDRVVEVSSSEAIIGIAALLRATGLLAGPSTGAAFVAATRLVECGALDRGSTIVIVAADHLSRYPDIIAKIKPHSPQVDE
LLKAWQ
>Mature_326_residues
MVLASKPSSREELLQAIERLSRIVGGTPTKCFTLGSYRFCVKLEYVNPAGSHKDRIALYMIKGAIESGAVDPGGCVAEVS
SGNTATSVAWIAHLLGLRSVLFVEKTASAVKKKLIRMFGGEIVEVTTEGSGRERAREEIAQMGCFFLDQMANEMNHLAHY
ETTASELLSQVKHVDAFVMGVGTAGTVTGVGRRLKETLGNTLNVAVTPKGSALAGGRGEDHIEGLVSDFVPDIYSRYSRY
VDRVVEVSSSEAIIGIAALLRATGLLAGPSTGAAFVAATRLVECGALDRGSTIVIVAADHLSRYPDIIAKIKPHSPQVDE
LLKAWQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=280, Percent_Identity=33.2142857142857, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI295821200, Length=280, Percent_Identity=33.2142857142857, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557415, Length=280, Percent_Identity=33.2142857142857, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=33.2203389830508, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788754, Length=301, Percent_Identity=34.21926910299, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32566674, Length=276, Percent_Identity=32.2463768115942, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562970, Length=278, Percent_Identity=32.7338129496403, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17535051, Length=308, Percent_Identity=31.8181818181818, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115535073, Length=250, Percent_Identity=38, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17534315, Length=286, Percent_Identity=32.5174825174825, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25147552, Length=284, Percent_Identity=31.6901408450704, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561720, Length=271, Percent_Identity=33.5793357933579, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI32566672, Length=209, Percent_Identity=30.622009569378, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71996324, Length=207, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=29.2063492063492, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=31.5315315315315, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24643623, Length=224, Percent_Identity=33.4821428571429, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20129101, Length=224, Percent_Identity=33.4821428571429, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34761; Mature: 34761

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLASKPSSREELLQAIERLSRIVGGTPTKCFTLGSYRFCVKLEYVNPAGSHKDRIALYM
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEEECCCCCCCCCEEEEE
IKGAIESGAVDPGGCVAEVSSGNTATSVAWIAHLLGLRSVLFVEKTASAVKKKLIRMFGG
EECHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIVEVTTEGSGRERAREEIAQMGCFFLDQMANEMNHLAHYETTASELLSQVKHVDAFVMG
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGTAGTVTGVGRRLKETLGNTLNVAVTPKGSALAGGRGEDHIEGLVSDFVPDIYSRYSRY
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VDRVVEVSSSEAIIGIAALLRATGLLAGPSTGAAFVAATRLVECGALDRGSTIVIVAADH
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHH
LSRYPDIIAKIKPHSPQVDELLKAWQ
HHHCHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MVLASKPSSREELLQAIERLSRIVGGTPTKCFTLGSYRFCVKLEYVNPAGSHKDRIALYM
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEEECCCCCCCCCEEEEE
IKGAIESGAVDPGGCVAEVSSGNTATSVAWIAHLLGLRSVLFVEKTASAVKKKLIRMFGG
EECHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIVEVTTEGSGRERAREEIAQMGCFFLDQMANEMNHLAHYETTASELLSQVKHVDAFVMG
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGTAGTVTGVGRRLKETLGNTLNVAVTPKGSALAGGRGEDHIEGLVSDFVPDIYSRYSRY
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VDRVVEVSSSEAIIGIAALLRATGLLAGPSTGAAFVAATRLVECGALDRGSTIVIVAADH
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHH
LSRYPDIIAKIKPHSPQVDELLKAWQ
HHHCHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA