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The map label for this gene is eriC [H]

Identifier: 124026887

GI number: 124026887

Start: 1841752

End: 1843110

Strand: Direct

Name: eriC [H]

Synonym: NATL1_21821

Alternate gene names: 124026887

Gene position: 1841752-1843110 (Clockwise)

Preceding gene: 124026886

Following gene: 124026890

Centisome position: 98.77

GC content: 36.5

Gene sequence:

>1359_bases
ATGATCAAAAGTAAAAGTAAAAATCCAATACAAAAAAAATCAACTCAAAGCATAAAAAAACTTCTACAGAGGAAATGGCT
AAATGTAATTCTTGCTCTCATACTTACAGGTTTAGGAGCAGCATTAACGGGAATATTATTTAAAACTGGGATTCATACAT
TAGAAGATTATCGATCGAATCTTCTTGCATCTATGCCTAGATGGATAGTTTTACCAATACTAGGAGCATTGGGAGGCTTG
ATTTCTGGATCGCTCATTCAAAATTTTGCCCCTGCAGCAAAAGGAGCGGGCGTAAGTCACATCATTGCTTTCCTTCGCCA
TAAGCCAGTCCCCATGGGATTAAGAGTTGGAATAGTAAAACTGTTTGCTGGAATTATTGCTATTGGAAGTGGATTTCCGC
TAGGCCCAGAAGGCCCGGCAGTACAAATGGGAGGATCAGTTGCCTGGAAAATGGCAAAATGGCTCAAAGCCCCTATTTCA
TTTCGCAGAGTCATAGTTGCAGCAGGCGGAGGAGCTGGAATTGCAGCAATTTTTAGTGCGCCTATTGGAGGCTTTGTCTA
TGCAATTGAAGAACTTCTAAATTCAGCCAGACCAGTAGTTCTCTTACTAGTAGTAGTAACAACTTTCTGGGCTGATAGTT
GCGCTGATATTTTGCAAGCGATTGGACTAGATCAAAAAGCTGGTGGATTTGTTAATAATTTAGGTTTTCAATTAGAGAGA
GCTTACACACCAGTAATCGAATTCTTTCCTATAGATTTTCTATACCTAATTTTTTTAGGAATTGTATTAGGATTATTAGC
AGAAATGTATTGCCGATATGTTTTAAAAATGCAAGTTCTAGGAAATAAATGGTTTAAAAATAAAACCATTGAAAGAATGA
GTTTATCGGGTTTATTGCTTGGTACTATGTATTCAATTATTCCGGAAAATTTTCACAATATCGAAGGATTACAAAAAATT
ATTGTTAATGAAAGTAGCAATTTCACACTTGCAATAAGTATATTTTTTATTTTATTCTTTGCCTCTGGCCTTGCTGCTGC
TTCAGGTGCACCAGGAGGTTTATTTTATCCAATGCTTACCTTGGGTGGAGCAATAGGTTTAGCAAGTGGTATTGGAGTCG
AGACAATAACTGGGCATGTTCCAACAACCTATATTTTCGCAGGCATGGGGAGATTCGTAGCGGGATGCTCAAGAACGCCT
CTAACAGCTATGTTTTTAGCTTTCGCATTAACTAAAAATCTTTTAATACTAAAACCACTCTTAATTACATGTATAGCTAG
CTTTTTAACTGCCAGAATATTTAATGAACACTCAATTTATGAAAGACAAATTACAATTGAAGAAGGAGAATTAATTTAA

Upstream 100 bases:

>100_bases
AGATACTTAAACTTTAATGAAATACCAAACTTTATCGAAGATGGTCGTGTAATAACAAAAGAAGAAGAGGCCTCTATTTT
ACAAACCTAAATTGAATTAA

Downstream 100 bases:

>100_bases
TACATTATTAAATTGTTTTAATGAATTATTGTAGCTCGTAGAATTATAGATCATACATCTAAGACCTATCAATAATATCC
AACCTAAGATATTAATTCTG

Product: putative chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MIKSKSKNPIQKKSTQSIKKLLQRKWLNVILALILTGLGAALTGILFKTGIHTLEDYRSNLLASMPRWIVLPILGALGGL
ISGSLIQNFAPAAKGAGVSHIIAFLRHKPVPMGLRVGIVKLFAGIIAIGSGFPLGPEGPAVQMGGSVAWKMAKWLKAPIS
FRRVIVAAGGGAGIAAIFSAPIGGFVYAIEELLNSARPVVLLLVVVTTFWADSCADILQAIGLDQKAGGFVNNLGFQLER
AYTPVIEFFPIDFLYLIFLGIVLGLLAEMYCRYVLKMQVLGNKWFKNKTIERMSLSGLLLGTMYSIIPENFHNIEGLQKI
IVNESSNFTLAISIFFILFFASGLAAASGAPGGLFYPMLTLGGAIGLASGIGVETITGHVPTTYIFAGMGRFVAGCSRTP
LTAMFLAFALTKNLLILKPLLITCIASFLTARIFNEHSIYERQITIEEGELI

Sequences:

>Translated_452_residues
MIKSKSKNPIQKKSTQSIKKLLQRKWLNVILALILTGLGAALTGILFKTGIHTLEDYRSNLLASMPRWIVLPILGALGGL
ISGSLIQNFAPAAKGAGVSHIIAFLRHKPVPMGLRVGIVKLFAGIIAIGSGFPLGPEGPAVQMGGSVAWKMAKWLKAPIS
FRRVIVAAGGGAGIAAIFSAPIGGFVYAIEELLNSARPVVLLLVVVTTFWADSCADILQAIGLDQKAGGFVNNLGFQLER
AYTPVIEFFPIDFLYLIFLGIVLGLLAEMYCRYVLKMQVLGNKWFKNKTIERMSLSGLLLGTMYSIIPENFHNIEGLQKI
IVNESSNFTLAISIFFILFFASGLAAASGAPGGLFYPMLTLGGAIGLASGIGVETITGHVPTTYIFAGMGRFVAGCSRTP
LTAMFLAFALTKNLLILKPLLITCIASFLTARIFNEHSIYERQITIEEGELI
>Mature_452_residues
MIKSKSKNPIQKKSTQSIKKLLQRKWLNVILALILTGLGAALTGILFKTGIHTLEDYRSNLLASMPRWIVLPILGALGGL
ISGSLIQNFAPAAKGAGVSHIIAFLRHKPVPMGLRVGIVKLFAGIIAIGSGFPLGPEGPAVQMGGSVAWKMAKWLKAPIS
FRRVIVAAGGGAGIAAIFSAPIGGFVYAIEELLNSARPVVLLLVVVTTFWADSCADILQAIGLDQKAGGFVNNLGFQLER
AYTPVIEFFPIDFLYLIFLGIVLGLLAEMYCRYVLKMQVLGNKWFKNKTIERMSLSGLLLGTMYSIIPENFHNIEGLQKI
IVNESSNFTLAISIFFILFFASGLAAASGAPGGLFYPMLTLGGAIGLASGIGVETITGHVPTTYIFAGMGRFVAGCSRTP
LTAMFLAFALTKNLLILKPLLITCIASFLTARIFNEHSIYERQITIEEGELI

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=416, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322500, Length=398, Percent_Identity=24.3718592964824, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48579; Mature: 48579

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSKSKNPIQKKSTQSIKKLLQRKWLNVILALILTGLGAALTGILFKTGIHTLEDYRSN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLASMPRWIVLPILGALGGLISGSLIQNFAPAAKGAGVSHIIAFLRHKPVPMGLRVGIVK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
LFAGIIAIGSGFPLGPEGPAVQMGGSVAWKMAKWLKAPISFRRVIVAAGGGAGIAAIFSA
HHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHC
PIGGFVYAIEELLNSARPVVLLLVVVTTFWADSCADILQAIGLDQKAGGFVNNLGFQLER
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHH
AYTPVIEFFPIDFLYLIFLGIVLGLLAEMYCRYVLKMQVLGNKWFKNKTIERMSLSGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GTMYSIIPENFHNIEGLQKIIVNESSNFTLAISIFFILFFASGLAAASGAPGGLFYPMLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGGAIGLASGIGVETITGHVPTTYIFAGMGRFVAGCSRTPLTAMFLAFALTKNLLILKPL
HHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LITCIASFLTARIFNEHSIYERQITIEEGELI
HHHHHHHHHHHHHHHCCHHHHEEEEECCCCCC
>Mature Secondary Structure
MIKSKSKNPIQKKSTQSIKKLLQRKWLNVILALILTGLGAALTGILFKTGIHTLEDYRSN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLASMPRWIVLPILGALGGLISGSLIQNFAPAAKGAGVSHIIAFLRHKPVPMGLRVGIVK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
LFAGIIAIGSGFPLGPEGPAVQMGGSVAWKMAKWLKAPISFRRVIVAAGGGAGIAAIFSA
HHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHHHHC
PIGGFVYAIEELLNSARPVVLLLVVVTTFWADSCADILQAIGLDQKAGGFVNNLGFQLER
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHH
AYTPVIEFFPIDFLYLIFLGIVLGLLAEMYCRYVLKMQVLGNKWFKNKTIERMSLSGLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GTMYSIIPENFHNIEGLQKIIVNESSNFTLAISIFFILFFASGLAAASGAPGGLFYPMLT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LGGAIGLASGIGVETITGHVPTTYIFAGMGRFVAGCSRTPLTAMFLAFALTKNLLILKPL
HHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LITCIASFLTARIFNEHSIYERQITIEEGELI
HHHHHHHHHHHHHHHCCHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA