Click here to switch to the map view.

The map label for this gene is clpX

Identifier: 124026831

GI number: 124026831

Start: 1782853

End: 1784208

Strand: Direct

Name: clpX

Synonym: NATL1_21261

Alternate gene names: 124026831

Gene position: 1782853-1784208 (Clockwise)

Preceding gene: 124026830

Following gene: 124026832

Centisome position: 95.61

GC content: 38.27

Gene sequence:

>1356_bases
ATGGCAAAATTTGAGGCCCATCTTAAATGCTCCTTTTGTGGCAAAGCCCAAGATCAAGTGAGGAAACTCATTGCTGGTCC
AGGAGTTTACATATGCGATGAATGTATTGACTTATGCAACGAAATTTTAGATGAAGAACTGATTGATAATCCAACCCATC
AAAGAAATGGTCATGAACAAAGCCGCAAAGCTAAAGCTGCCACAACGACAGCTAAACCAGCTCCAACCTTGGCATCCATC
CCCAAGCCAATTGAAATTAAAAAGTTTTTAGATGCTCAAGTAGTTGGGCAAGAACCAGCAAAAAAAATCTTATCGGTAGC
TGTCTACAATCACTACAAGAGACTTGCTTGGAAAGGTGACGGGTCTGGCGAGACTGATTTAACGGCAACAAAATTACAAA
AATCTAATATTTTATTAATTGGACCAACTGGATGCGGAAAGACATTACTTGCCCAAACATTAGCTGAAATGCTTGATGTT
CCATTTGCTGTTGCTGATGCAACAACTCTTACTGAAGCTGGATATGTTGGAGAGGATGTAGAAAACATTCTTTTACGTCT
CCTACAGAAAGCAGATATGGACGTGGATTTAGCACAAAGAGGAATTATTTACATAGATGAAATTGACAAAATTGCTAGAA
AAAGTGAAAACCCATCCATTACTAGAGATGTCTCTGGAGAAGGGGTGCAACAAGCTCTTCTAAAAATGCTCGAGGGTACT
GTTGCCAATGTTCCTCCTCAGGGAGGAAGAAAGCATCCTTACGGTGACTCTATTCAAATTGATACGAGCCAAATACTCTT
TATATGTGGTGGAGCATTTGTTGGCTTAGATGACGTAGTGGAAAAAAGACTTGGAAAAAATTCAATTGGTTTCATACAAA
ATGAAAACAGGACAAGAACAAAATCTAATAGAGATCGTGTTGGTGCAGATCTAATTAATGACCTTGAGCCCGACGACCTA
GTGAAATATGGTCTGATTCCCGAATTTATTGGAAGAATGCCTGTCAGTGCAATATTAGAACCACTAAATGCTAAAGCACT
TGAGTCCATTCTCACGGAACCAAGAGATGCTTTAGTAAAACAATTTAGAACTTTATTAAGTATGGATAATGTAGAACTTT
CATTTGACGAGGATGCTGTTGAGGCAATTGCGCAAGAAGCTTATAAAAGAAAAACCGGAGCTAGAGCGTTGCGAGGAATT
GTTGAAGAAATCATGCTAGATCTAATGTATAGTCTTCCATCTCAAACTAAAATTAAAAATTTCAACGTAACAAAGAAAAT
GGTTGATGAAAGTACTGGTGGTAAAGTTGTTCCTCTCTTATCAAATGAAAAAAGAATCGTTAAGGAATCTGCCTAG

Upstream 100 bases:

>100_bases
TTAAGGAAGGCTGACAAGACATCAATCCTCAATGATCCTATTAATTGAGACTGAACAAAATTCATTATCGGTCTATCTAA
CCTGTTTTTTTTAGAGCTCG

Downstream 100 bases:

>100_bases
AAAGAATAAACTATGAATACCTTTATTAAATTTAATTAGTGTAATAAAAAAAATTATAAAATTTGAAAAAATTAAATTAG
TCAAATATTTGATGAATGAC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAKFEAHLKCSFCGKAQDQVRKLIAGPGVYICDECIDLCNEILDEELIDNPTHQRNGHEQSRKAKAATTTAKPAPTLASI
PKPIEIKKFLDAQVVGQEPAKKILSVAVYNHYKRLAWKGDGSGETDLTATKLQKSNILLIGPTGCGKTLLAQTLAEMLDV
PFAVADATTLTEAGYVGEDVENILLRLLQKADMDVDLAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGT
VANVPPQGGRKHPYGDSIQIDTSQILFICGGAFVGLDDVVEKRLGKNSIGFIQNENRTRTKSNRDRVGADLINDLEPDDL
VKYGLIPEFIGRMPVSAILEPLNAKALESILTEPRDALVKQFRTLLSMDNVELSFDEDAVEAIAQEAYKRKTGARALRGI
VEEIMLDLMYSLPSQTKIKNFNVTKKMVDESTGGKVVPLLSNEKRIVKESA

Sequences:

>Translated_451_residues
MAKFEAHLKCSFCGKAQDQVRKLIAGPGVYICDECIDLCNEILDEELIDNPTHQRNGHEQSRKAKAATTTAKPAPTLASI
PKPIEIKKFLDAQVVGQEPAKKILSVAVYNHYKRLAWKGDGSGETDLTATKLQKSNILLIGPTGCGKTLLAQTLAEMLDV
PFAVADATTLTEAGYVGEDVENILLRLLQKADMDVDLAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGT
VANVPPQGGRKHPYGDSIQIDTSQILFICGGAFVGLDDVVEKRLGKNSIGFIQNENRTRTKSNRDRVGADLINDLEPDDL
VKYGLIPEFIGRMPVSAILEPLNAKALESILTEPRDALVKQFRTLLSMDNVELSFDEDAVEAIAQEAYKRKTGARALRGI
VEEIMLDLMYSLPSQTKIKNFNVTKKMVDESTGGKVVPLLSNEKRIVKESA
>Mature_450_residues
AKFEAHLKCSFCGKAQDQVRKLIAGPGVYICDECIDLCNEILDEELIDNPTHQRNGHEQSRKAKAATTTAKPAPTLASIP
KPIEIKKFLDAQVVGQEPAKKILSVAVYNHYKRLAWKGDGSGETDLTATKLQKSNILLIGPTGCGKTLLAQTLAEMLDVP
FAVADATTLTEAGYVGEDVENILLRLLQKADMDVDLAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGTV
ANVPPQGGRKHPYGDSIQIDTSQILFICGGAFVGLDDVVEKRLGKNSIGFIQNENRTRTKSNRDRVGADLINDLEPDDLV
KYGLIPEFIGRMPVSAILEPLNAKALESILTEPRDALVKQFRTLLSMDNVELSFDEDAVEAIAQEAYKRKTGARALRGIV
EEIMLDLMYSLPSQTKIKNFNVTKKMVDESTGGKVVPLLSNEKRIVKESA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=318, Percent_Identity=47.7987421383648, Blast_Score=286, Evalue=4e-77,
Organism=Escherichia coli, GI1786642, Length=435, Percent_Identity=57.7011494252874, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1790366, Length=109, Percent_Identity=37.6146788990826, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71982908, Length=329, Percent_Identity=43.161094224924, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI71982905, Length=329, Percent_Identity=43.161094224924, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71988663, Length=393, Percent_Identity=38.9312977099237, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71988660, Length=253, Percent_Identity=39.9209486166008, Blast_Score=164, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6319704, Length=445, Percent_Identity=38.876404494382, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24648291, Length=316, Percent_Identity=46.8354430379747, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24648289, Length=316, Percent_Identity=46.8354430379747, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_PROM1 (A2C5C2)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015946.1
- ProteinModelPortal:   A2C5C2
- STRING:   A2C5C2
- GeneID:   4780921
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_21261
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   PMAR167555:NATL1_21261-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 49458; Mature: 49327

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFEAHLKCSFCGKAQDQVRKLIAGPGVYICDECIDLCNEILDEELIDNPTHQRNGHEQ
CCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SRKAKAATTTAKPAPTLASIPKPIEIKKFLDAQVVGQEPAKKILSVAVYNHYKRLAWKGD
HHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCC
GSGETDLTATKLQKSNILLIGPTGCGKTLLAQTLAEMLDVPFAVADATTLTEAGYVGEDV
CCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHH
ENILLRLLQKADMDVDLAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGT
HHHHHHHHHHCCCCHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCH
VANVPPQGGRKHPYGDSIQIDTSQILFICGGAFVGLDDVVEKRLGKNSIGFIQNENRTRT
HCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCC
KSNRDRVGADLINDLEPDDLVKYGLIPEFIGRMPVSAILEPLNAKALESILTEPRDALVK
CCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCHHHHHHHCCHHHHHHHHCCHHHHHHH
QFRTLLSMDNVELSFDEDAVEAIAQEAYKRKTGARALRGIVEEIMLDLMYSLPSQTKIKN
HHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
FNVTKKMVDESTGGKVVPLLSNEKRIVKESA
CCHHHHHHHCCCCCEEEEECCCCHHHHCCCC
>Mature Secondary Structure 
AKFEAHLKCSFCGKAQDQVRKLIAGPGVYICDECIDLCNEILDEELIDNPTHQRNGHEQ
CCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
SRKAKAATTTAKPAPTLASIPKPIEIKKFLDAQVVGQEPAKKILSVAVYNHYKRLAWKGD
HHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCC
GSGETDLTATKLQKSNILLIGPTGCGKTLLAQTLAEMLDVPFAVADATTLTEAGYVGEDV
CCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHH
ENILLRLLQKADMDVDLAQRGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKMLEGT
HHHHHHHHHHCCCCHHHHHCCCEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCH
VANVPPQGGRKHPYGDSIQIDTSQILFICGGAFVGLDDVVEKRLGKNSIGFIQNENRTRT
HCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCC
KSNRDRVGADLINDLEPDDLVKYGLIPEFIGRMPVSAILEPLNAKALESILTEPRDALVK
CCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCHHHHHHHCCHHHHHHHHCCHHHHHHH
QFRTLLSMDNVELSFDEDAVEAIAQEAYKRKTGARALRGIVEEIMLDLMYSLPSQTKIKN
HHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
FNVTKKMVDESTGGKVVPLLSNEKRIVKESA
CCHHHHHHHCCCCCEEEEECCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA