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The map label for this gene is dnaX [H]

Identifier: 124026832

GI number: 124026832

Start: 1784369

End: 1786066

Strand: Direct

Name: dnaX [H]

Synonym: NATL1_21271

Alternate gene names: 124026832

Gene position: 1784369-1786066 (Clockwise)

Preceding gene: 124026831

Following gene: 124026835

Centisome position: 95.69

GC content: 31.51

Gene sequence:

>1698_bases
ATGATAACGACTTATGAGCCATTACATCATAAATATCGCCCAACAAGCTTTGACGAACTAGTTGGGCAAGATCCAATCAA
GTCAACATTAAAACAGGCATTAATTAGTGATCGAATTGCCCCTGCATATATTTTTTCTGGACCTCGAGGAACAGGTAAAA
CATCAAGCGCGCGCATTTTCGCAAAGTCTTTGAATTGTTTAAAAAGTGAAAAAGCTACAACCACGCCTTGCGGTCAATGT
GAACTCTGTAAGGGAATTAGCTCTGGCAATGCATTGGATGTCATTGAAATTGATGCAGCTTCGAATACAGGTGTTGAAAA
TATTCGTGAATTAATAGAAAGATCAAGATTTGCTCCTGCAAAAGCTCGCTGGAAAGTTTATGTCATAGATGAATGCCATA
TGCTTTCAACTGCAGCCTTTAATGCACTTTTAAAAACGTTAGAAGAACCTCCCCGTCAAGTCGTATTTATTCTTGCGACA
ACTGATCCTCAACGCGTTTTACCTACAATTCTTAGTAGATGCATGCGGTTTGATTTTAGAAGAATAGCTCTGCATGATTT
AGAGAGTCATTTAATCAAAATTGCTAAAAAAGAAGAAATTCAAATCAACGAAGAAGCAATATCATTAATTGCCAAACACT
CCCAAGGAGGGTTGAGAGATGCGGAAAGTTTACTTGATCAAGTCAGTTTACTTCCTCCGCCAATAACTCAATTAAACATA
ATTAATTTAATAGGAGCTATACCAGAAGAAGAATTAATTATATTAGCAAAATCTTTAATAACTAAAGATCCGAATTCTAT
TCTGAATATTTGTAATAGCCTAATAAATAAAGGGAAAGAGCCAATTGCAATTTTACAAGGAATAGCATCTATATTAAGAG
ATCTAGTTGTAACAAAAGTCACAAATAAACCAACAAATTTATGTAATATTTCCCGAGAGCATAGTGAAAGTTTAAACGAC
TTAGCAACATCTAGTAATCTTGATCAAATACTCAATCTACAGGCCAAGTTAAAAGGATCAGAAAGTAATATAAGAAACAG
TAATCAACCAAACTTATGGCTAGAAATTCATTTACTTGGAATGCTTACAGATGAAGTTTCCAAAGAAAATAATAAAATCG
AACAATCCTTAGTTAAAACCAAAATATCAGATAATTCTGAATCTAAAAATACAAATAATACATCAAATAGAATAGTTCCT
AATACAGAGAAAGAACAAATTAAAACAACAGCTTTTCTAGACGAAACAAAAACTAGTCCAACTTTAAATCTTGATGATAT
TTGGAAAAAAGTTATAGCTATGTTAGAGCTTCCTTCAACAAAGATGCTACTTTCACAACAAGCTAAATTAATCAATCTGA
ATTCAGATTCTGCTGAAATAGCAATTTCAGAAAAATGGATAAATATGATTCAAAGTCGAAAAAATCTGATTGAAGATGCT
TTTTATAAAGCGAGAGGATCGTCAACTAAAGTTGTATTAATACAACAAAAAGATAACTTATCAAATCATAAAAAAGTTGA
AGATAATCTTCAAAAAATAGAACAAAAAAATCAAATTAAAATTGATAGAGAGCCAAATAAAAATACTATTAAAGAGGAAA
AAATAGAGTCAAAAAATAATTTAAAGGTAAATTCTATTGATCAAAAAGCTAAGCAATTCGCAGACTTCTTTAATGGAGAA
ATTGTGAATCTTGAATGA

Upstream 100 bases:

>100_bases
ATTTGAAAAAATTAAATTAGTCAAATATTTGATGAATGACTATAGATTATGAATATGATCAAACAACTCAAGATCAAATT
CATTCATATTTTTAATTGAA

Downstream 100 bases:

>100_bases
ATAAAATAACTTCCTCAAGCACCAATATGATCGGTTTTTTCCCAAATCAACGTCTTACGAAATAATGACATCTTAACTGC
TATAAAGGGTATAACTATAA

Product: DNA polymerase, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MITTYEPLHHKYRPTSFDELVGQDPIKSTLKQALISDRIAPAYIFSGPRGTGKTSSARIFAKSLNCLKSEKATTTPCGQC
ELCKGISSGNALDVIEIDAASNTGVENIRELIERSRFAPAKARWKVYVIDECHMLSTAAFNALLKTLEEPPRQVVFILAT
TDPQRVLPTILSRCMRFDFRRIALHDLESHLIKIAKKEEIQINEEAISLIAKHSQGGLRDAESLLDQVSLLPPPITQLNI
INLIGAIPEEELIILAKSLITKDPNSILNICNSLINKGKEPIAILQGIASILRDLVVTKVTNKPTNLCNISREHSESLND
LATSSNLDQILNLQAKLKGSESNIRNSNQPNLWLEIHLLGMLTDEVSKENNKIEQSLVKTKISDNSESKNTNNTSNRIVP
NTEKEQIKTTAFLDETKTSPTLNLDDIWKKVIAMLELPSTKMLLSQQAKLINLNSDSAEIAISEKWINMIQSRKNLIEDA
FYKARGSSTKVVLIQQKDNLSNHKKVEDNLQKIEQKNQIKIDREPNKNTIKEEKIESKNNLKVNSIDQKAKQFADFFNGE
IVNLE

Sequences:

>Translated_565_residues
MITTYEPLHHKYRPTSFDELVGQDPIKSTLKQALISDRIAPAYIFSGPRGTGKTSSARIFAKSLNCLKSEKATTTPCGQC
ELCKGISSGNALDVIEIDAASNTGVENIRELIERSRFAPAKARWKVYVIDECHMLSTAAFNALLKTLEEPPRQVVFILAT
TDPQRVLPTILSRCMRFDFRRIALHDLESHLIKIAKKEEIQINEEAISLIAKHSQGGLRDAESLLDQVSLLPPPITQLNI
INLIGAIPEEELIILAKSLITKDPNSILNICNSLINKGKEPIAILQGIASILRDLVVTKVTNKPTNLCNISREHSESLND
LATSSNLDQILNLQAKLKGSESNIRNSNQPNLWLEIHLLGMLTDEVSKENNKIEQSLVKTKISDNSESKNTNNTSNRIVP
NTEKEQIKTTAFLDETKTSPTLNLDDIWKKVIAMLELPSTKMLLSQQAKLINLNSDSAEIAISEKWINMIQSRKNLIEDA
FYKARGSSTKVVLIQQKDNLSNHKKVEDNLQKIEQKNQIKIDREPNKNTIKEEKIESKNNLKVNSIDQKAKQFADFFNGE
IVNLE
>Mature_565_residues
MITTYEPLHHKYRPTSFDELVGQDPIKSTLKQALISDRIAPAYIFSGPRGTGKTSSARIFAKSLNCLKSEKATTTPCGQC
ELCKGISSGNALDVIEIDAASNTGVENIRELIERSRFAPAKARWKVYVIDECHMLSTAAFNALLKTLEEPPRQVVFILAT
TDPQRVLPTILSRCMRFDFRRIALHDLESHLIKIAKKEEIQINEEAISLIAKHSQGGLRDAESLLDQVSLLPPPITQLNI
INLIGAIPEEELIILAKSLITKDPNSILNICNSLINKGKEPIAILQGIASILRDLVVTKVTNKPTNLCNISREHSESLND
LATSSNLDQILNLQAKLKGSESNIRNSNQPNLWLEIHLLGMLTDEVSKENNKIEQSLVKTKISDNSESKNTNNTSNRIVP
NTEKEQIKTTAFLDETKTSPTLNLDDIWKKVIAMLELPSTKMLLSQQAKLINLNSDSAEIAISEKWINMIQSRKNLIEDA
FYKARGSSTKVVLIQQKDNLSNHKKVEDNLQKIEQKNQIKIDREPNKNTIKEEKIESKNNLKVNSIDQKAKQFADFFNGE
IVNLE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=284, Percent_Identity=28.169014084507, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI31881687, Length=284, Percent_Identity=28.169014084507, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI6677723, Length=244, Percent_Identity=26.2295081967213, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI194306571, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194306567, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI31563534, Length=223, Percent_Identity=25.1121076233184, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=307, Percent_Identity=39.7394136807818, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71986063, Length=305, Percent_Identity=24.5901639344262, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17554730, Length=226, Percent_Identity=26.1061946902655, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17541988, Length=218, Percent_Identity=24.7706422018349, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=299, Percent_Identity=25.0836120401338, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=294, Percent_Identity=24.4897959183673, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=220, Percent_Identity=24.5454545454545, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921076, Length=259, Percent_Identity=24.7104247104247, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647857, Length=221, Percent_Identity=25.3393665158371, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18859927, Length=260, Percent_Identity=26.5384615384615, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63279; Mature: 63279

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTYEPLHHKYRPTSFDELVGQDPIKSTLKQALISDRIAPAYIFSGPRGTGKTSSARIF
CCCCCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
AKSLNCLKSEKATTTPCGQCELCKGISSGNALDVIEIDAASNTGVENIRELIERSRFAPA
HHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
KARWKVYVIDECHMLSTAAFNALLKTLEEPPRQVVFILATTDPQRVLPTILSRCMRFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
RIALHDLESHLIKIAKKEEIQINEEAISLIAKHSQGGLRDAESLLDQVSLLPPPITQLNI
HHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHH
INLIGAIPEEELIILAKSLITKDPNSILNICNSLINKGKEPIAILQGIASILRDLVVTKV
HHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TNKPTNLCNISREHSESLNDLATSSNLDQILNLQAKLKGSESNIRNSNQPNLWLEIHLLG
CCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEH
MLTDEVSKENNKIEQSLVKTKISDNSESKNTNNTSNRIVPNTEKEQIKTTAFLDETKTSP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
TLNLDDIWKKVIAMLELPSTKMLLSQQAKLINLNSDSAEIAISEKWINMIQSRKNLIEDA
CCCHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHH
FYKARGSSTKVVLIQQKDNLSNHKKVEDNLQKIEQKNQIKIDREPNKNTIKEEKIESKNN
HHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCC
LKVNSIDQKAKQFADFFNGEIVNLE
CEECHHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MITTYEPLHHKYRPTSFDELVGQDPIKSTLKQALISDRIAPAYIFSGPRGTGKTSSARIF
CCCCCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHH
AKSLNCLKSEKATTTPCGQCELCKGISSGNALDVIEIDAASNTGVENIRELIERSRFAPA
HHHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
KARWKVYVIDECHMLSTAAFNALLKTLEEPPRQVVFILATTDPQRVLPTILSRCMRFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
RIALHDLESHLIKIAKKEEIQINEEAISLIAKHSQGGLRDAESLLDQVSLLPPPITQLNI
HHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHH
INLIGAIPEEELIILAKSLITKDPNSILNICNSLINKGKEPIAILQGIASILRDLVVTKV
HHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TNKPTNLCNISREHSESLNDLATSSNLDQILNLQAKLKGSESNIRNSNQPNLWLEIHLLG
CCCCCCHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEH
MLTDEVSKENNKIEQSLVKTKISDNSESKNTNNTSNRIVPNTEKEQIKTTAFLDETKTSP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
TLNLDDIWKKVIAMLELPSTKMLLSQQAKLINLNSDSAEIAISEKWINMIQSRKNLIEDA
CCCHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHHHH
FYKARGSSTKVVLIQQKDNLSNHKKVEDNLQKIEQKNQIKIDREPNKNTIKEEKIESKNN
HHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHCCCCC
LKVNSIDQKAKQFADFFNGEIVNLE
CEECHHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]