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The map label for this gene is clpP3 [H]

Identifier: 124026830

GI number: 124026830

Start: 1782092

End: 1782748

Strand: Direct

Name: clpP3 [H]

Synonym: NATL1_21251

Alternate gene names: 124026830

Gene position: 1782092-1782748 (Clockwise)

Preceding gene: 124026829

Following gene: 124026831

Centisome position: 95.57

GC content: 40.64

Gene sequence:

>657_bases
TTGATTGAAGCAAGACAAAATCACCCCATTCATAGTTTATGGAATAACTCCTCTCTATTTTCAGGACCGGGAGTGTTACC
AACAGTAATCGAACAATCAGGTCAAGGTGATAGGGCATTTGATATTTACTCTCGGTTACTTCGTGAAAGAATCATCTTTC
TAGGAACTGATGTAAATGATCAAGTTGCTGATGCATTAGTAGCTCAAATGCTTTTTTTAGAAGCTGATGATCCAGAAAAA
GATATTCAGCTGTACGTGAACTCTCCTGGAGGGTCAGTAACTGCGGGCCTGGCTATTTACGACACCATGCAGCAAGTTAG
TCCGGATGTCATAACAATTTGCTACGGGCTTGCAGCAAGCATGGGTGCTTTTCTTCTCTCTGGAGGGACAAAAGGGAAAA
GACTTGCATTGCCAAATTCGAGAATAATGATTCATCAACCTCTTGGTGGAGCTCAGGGTCAAGCTGTCGAAATTGAAATT
CAAGCCAAAGAAATTCTCTATTTAAAAGAGACTCTTAATTCACTTTTGGCTGAGCATACTGGACAAAATATTCAAAAAAT
TTCAGAAGACACTGATCGAGACCACTTTCTTTCTCCCCAAGAAGCGGTTGAATATGGCCTGATCGACAAAGTGGTTTCTA
ATCTCAACTCCATATGA

Upstream 100 bases:

>100_bases
AAGAAAACAACAAAAACAAATAAAGAAAAGAAAAGTTCTAAAACACCCAAATCCTAGTTTCTACGCATAGATTAGTAGTA
TTAGCTATTTAAAATTCAAG

Downstream 100 bases:

>100_bases
ATCATTAAGGAAGGCTGACAAGACATCAATCCTCAATGATCCTATTAATTGAGACTGAACAAAATTCATTATCGGTCTAT
CTAACCTGTTTTTTTTAGAG

Product: Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 3 [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MIEARQNHPIHSLWNNSSLFSGPGVLPTVIEQSGQGDRAFDIYSRLLRERIIFLGTDVNDQVADALVAQMLFLEADDPEK
DIQLYVNSPGGSVTAGLAIYDTMQQVSPDVITICYGLAASMGAFLLSGGTKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILYLKETLNSLLAEHTGQNIQKISEDTDRDHFLSPQEAVEYGLIDKVVSNLNSI

Sequences:

>Translated_218_residues
MIEARQNHPIHSLWNNSSLFSGPGVLPTVIEQSGQGDRAFDIYSRLLRERIIFLGTDVNDQVADALVAQMLFLEADDPEK
DIQLYVNSPGGSVTAGLAIYDTMQQVSPDVITICYGLAASMGAFLLSGGTKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILYLKETLNSLLAEHTGQNIQKISEDTDRDHFLSPQEAVEYGLIDKVVSNLNSI
>Mature_218_residues
MIEARQNHPIHSLWNNSSLFSGPGVLPTVIEQSGQGDRAFDIYSRLLRERIIFLGTDVNDQVADALVAQMLFLEADDPEK
DIQLYVNSPGGSVTAGLAIYDTMQQVSPDVITICYGLAASMGAFLLSGGTKGKRLALPNSRIMIHQPLGGAQGQAVEIEI
QAKEILYLKETLNSLLAEHTGQNIQKISEDTDRDHFLSPQEAVEYGLIDKVVSNLNSI

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=55.3191489361702, Blast_Score=224, Evalue=4e-59,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=63.7305699481865, Blast_Score=270, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=52.8497409326425, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=51.5789473684211, Blast_Score=215, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23778; Mature: 23778

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEARQNHPIHSLWNNSSLFSGPGVLPTVIEQSGQGDRAFDIYSRLLRERIIFLGTDVND
CCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCH
QVADALVAQMLFLEADDPEKDIQLYVNSPGGSVTAGLAIYDTMQQVSPDVITICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHH
MGAFLLSGGTKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILYLKETLNSLLAEHT
HHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQNIQKISEDTDRDHFLSPQEAVEYGLIDKVVSNLNSI
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIEARQNHPIHSLWNNSSLFSGPGVLPTVIEQSGQGDRAFDIYSRLLRERIIFLGTDVND
CCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCH
QVADALVAQMLFLEADDPEKDIQLYVNSPGGSVTAGLAIYDTMQQVSPDVITICYGLAAS
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHH
MGAFLLSGGTKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILYLKETLNSLLAEHT
HHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHC
GQNIQKISEDTDRDHFLSPQEAVEYGLIDKVVSNLNSI
CCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA