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The map label for this gene is dapA [H]

Identifier: 124026826

GI number: 124026826

Start: 1778538

End: 1779485

Strand: Reverse

Name: dapA [H]

Synonym: NATL1_21211

Alternate gene names: 124026826

Gene position: 1779485-1778538 (Counterclockwise)

Preceding gene: 124026827

Following gene: 124026825

Centisome position: 95.43

GC content: 40.3

Gene sequence:

>948_bases
ATGCAGTGCAGATTGCTGAACTTCTACTGCCAAAGAATTATGAATAAGTCAGCTTTATTATCACCAGCTCCTTTTGGAAG
GCTCCTAACCGCAATGGTGACCCCATTTGATGATGAAGGGAAAGTTGATTATGGTCTTGCTGCCGATTTGGCAAATTATT
TGGTAGATCAAGGTTCAGATGGCATCGTTGTATGTGGAACTACTGGAGAGTCACCGACTCTAAGTTGGCAAGAACAACAA
AAATTGCTGGAAATAGTAAGAAATTCCTTAGGCTCTAGGGCTAAAGTTTTAGCTGGAACAGGCAGTAATTCGACTTCTGA
GGCAATTGAAGCTACAAAGGAAGCAGCTAATTCAGGCGCTGATGGAGCATTAGTTGTTGTTCCTTATTACAACAAACCAC
CGCAAGAGGGATTAGAAGTTCATTTTCGCGCTATTGCAAATGCCGCTCCAAAGTTGCCTTTAATGCTCTATAACATCCCT
GGGCGGACAGGGTGTTCAATATCGCCTAGTATTGTTAGTAAGCTTATGGATTGCAGTAATGTAGTCAGTTTTAAAGCTGC
AAGTGGAACAACTGAGGAAGTGACTCAATTAAGAAACTATTGTGGATCAGATTTAGCTATTTATAGCGGTGATGATGCTT
TGGTTTTACCAATGCTTTCAGTAGGGGCAGTTGGTGTTGTTAGTGTTGCAAGTCATTTAGTTGCACCTAATTTGAAGAAA
ATTATAGAGAGTTTTTTAGAGGGTAAATATTCTGAGGCACTTTATTTGCACGAGACATTACAACCTCTTTTTAAATCCCT
TTTTGCAACTACAAATCCAATTCCTGTTAAAGCGGCACTTCAACTCATCGGTTGGTCTGTTGGACCTCCTCGAAGTCCTC
TAGTCTCTTTAAACAGTGAAATGAAAGAAGAACTCGTGAAGATACTCTCTTCTCTGAGATTGATTTGA

Upstream 100 bases:

>100_bases
GATCCAATATCAGTTGGTCGAATAAGGCAAGATATAAGTAACCCGAATGCTTTGGAACTATGGTTATGTGGAGATCAAAT
CCGCAAGGGTGCAGCACTTA

Downstream 100 bases:

>100_bases
TCTACTCCCTCTATCCATAGTGGGTGTGGCTTTCATTTAGGTAACAATCAAGTTTTTTCACATAAATTTTTCCATGACAT
CAAGTTCAATGAATTCTCAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MQCRLLNFYCQRIMNKSALLSPAPFGRLLTAMVTPFDDEGKVDYGLAADLANYLVDQGSDGIVVCGTTGESPTLSWQEQQ
KLLEIVRNSLGSRAKVLAGTGSNSTSEAIEATKEAANSGADGALVVVPYYNKPPQEGLEVHFRAIANAAPKLPLMLYNIP
GRTGCSISPSIVSKLMDCSNVVSFKAASGTTEEVTQLRNYCGSDLAIYSGDDALVLPMLSVGAVGVVSVASHLVAPNLKK
IIESFLEGKYSEALYLHETLQPLFKSLFATTNPIPVKAALQLIGWSVGPPRSPLVSLNSEMKEELVKILSSLRLI

Sequences:

>Translated_315_residues
MQCRLLNFYCQRIMNKSALLSPAPFGRLLTAMVTPFDDEGKVDYGLAADLANYLVDQGSDGIVVCGTTGESPTLSWQEQQ
KLLEIVRNSLGSRAKVLAGTGSNSTSEAIEATKEAANSGADGALVVVPYYNKPPQEGLEVHFRAIANAAPKLPLMLYNIP
GRTGCSISPSIVSKLMDCSNVVSFKAASGTTEEVTQLRNYCGSDLAIYSGDDALVLPMLSVGAVGVVSVASHLVAPNLKK
IIESFLEGKYSEALYLHETLQPLFKSLFATTNPIPVKAALQLIGWSVGPPRSPLVSLNSEMKEELVKILSSLRLI
>Mature_315_residues
MQCRLLNFYCQRIMNKSALLSPAPFGRLLTAMVTPFDDEGKVDYGLAADLANYLVDQGSDGIVVCGTTGESPTLSWQEQQ
KLLEIVRNSLGSRAKVLAGTGSNSTSEAIEATKEAANSGADGALVVVPYYNKPPQEGLEVHFRAIANAAPKLPLMLYNIP
GRTGCSISPSIVSKLMDCSNVVSFKAASGTTEEVTQLRNYCGSDLAIYSGDDALVLPMLSVGAVGVVSVASHLVAPNLKK
IIESFLEGKYSEALYLHETLQPLFKSLFATTNPIPVKAALQLIGWSVGPPRSPLVSLNSEMKEELVKILSSLRLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=298, Percent_Identity=27.1812080536913, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI31543060, Length=279, Percent_Identity=27.2401433691756, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1788823, Length=280, Percent_Identity=37.8571428571429, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=28.8065843621399, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786463, Length=288, Percent_Identity=28.4722222222222, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082415, Length=295, Percent_Identity=27.4576271186441, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 33666; Mature: 33666

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCRLLNFYCQRIMNKSALLSPAPFGRLLTAMVTPFDDEGKVDYGLAADLANYLVDQGSD
CCCHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
GIVVCGTTGESPTLSWQEQQKLLEIVRNSLGSRAKVLAGTGSNSTSEAIEATKEAANSGA
CEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCC
DGALVVVPYYNKPPQEGLEVHFRAIANAAPKLPLMLYNIPGRTGCSISPSIVSKLMDCSN
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
VVSFKAASGTTEEVTQLRNYCGSDLAIYSGDDALVLPMLSVGAVGVVSVASHLVAPNLKK
HHEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHH
IIESFLEGKYSEALYLHETLQPLFKSLFATTNPIPVKAALQLIGWSVGPPRSPLVSLNSE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
MKEELVKILSSLRLI
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MQCRLLNFYCQRIMNKSALLSPAPFGRLLTAMVTPFDDEGKVDYGLAADLANYLVDQGSD
CCCHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
GIVVCGTTGESPTLSWQEQQKLLEIVRNSLGSRAKVLAGTGSNSTSEAIEATKEAANSGA
CEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCC
DGALVVVPYYNKPPQEGLEVHFRAIANAAPKLPLMLYNIPGRTGCSISPSIVSKLMDCSN
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
VVSFKAASGTTEEVTQLRNYCGSDLAIYSGDDALVLPMLSVGAVGVVSVASHLVAPNLKK
HHEECCCCCCHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHCCCHHH
IIESFLEGKYSEALYLHETLQPLFKSLFATTNPIPVKAALQLIGWSVGPPRSPLVSLNSE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHH
MKEELVKILSSLRLI
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA