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The map label for this gene is msrA2 [H]

Identifier: 124026465

GI number: 124026465

Start: 1441129

End: 1441740

Strand: Reverse

Name: msrA2 [H]

Synonym: NATL1_17601

Alternate gene names: 124026465

Gene position: 1441740-1441129 (Counterclockwise)

Preceding gene: 124026466

Following gene: 124026462

Centisome position: 77.32

GC content: 32.68

Gene sequence:

>612_bases
ATGATTGCTATGAATAAAATCTTCAGAAGACTAATAGTATTTTCTATACTTCTGCAATTATTAATAGCTTGTCCTTTGAA
AGCATTTGCCGAATCAGAAGAAGCTATTTTTGCAGGTGGTTGCTTTTGGTGCCTAGAACATGATCTAGAAAAACTTGATG
GAGTCGTCTCTGCAGAAAGTGGATACTCTGGAGGAGATTTGATTAATCCCACGTATCAAGATCATAGTGGGCATCAAGAA
GTTGTGAAAGTTATTTTTGATTCTGACATTATTAGCTATAAAGATTTACTTAAGCAATATTGGGTTAATATTGATCCTTT
TGATAATAATGGACAATTTTGTGATAGAGGTGATTCATATAAGCCAGTTATTTTTACATCTAATCAAGAACAAAAGCGAG
ATGCAAAAGAGAGTCAAGAAACTATCTCTGTTGGATTGAATATACCCTTGGAGCAATTAAAGGTTGATATTGTTGAGTCA
AAAGTCTTTTGGTTGGCAGAGAACTATCATCAAGATTTTGCAGTTAAAAATCCACTCAAATACAATTTTTATAGGACCAG
TTGTGGTAGAGATAATAGATTAAAAAAAGTCTGGGGAGAATATAAGTATTAA

Upstream 100 bases:

>100_bases
AAGAGGACATAAAGCTTGGTTATGAAAGATTGAAAGATAAATTAGGAAAACCTGGAGTTACAGATAGAGCATCAAGGGAT
ATTCTAGACTTATTAATTTA

Downstream 100 bases:

>100_bases
CAAAATAATTAATCTATAGATCTTAAATATATATAGTTTAGATCTATAGATTATGCGTGAATAAATTAATTGGTGTTTAG
ACTCAACTCCTTGATCCAAT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MIAMNKIFRRLIVFSILLQLLIACPLKAFAESEEAIFAGGCFWCLEHDLEKLDGVVSAESGYSGGDLINPTYQDHSGHQE
VVKVIFDSDIISYKDLLKQYWVNIDPFDNNGQFCDRGDSYKPVIFTSNQEQKRDAKESQETISVGLNIPLEQLKVDIVES
KVFWLAENYHQDFAVKNPLKYNFYRTSCGRDNRLKKVWGEYKY

Sequences:

>Translated_203_residues
MIAMNKIFRRLIVFSILLQLLIACPLKAFAESEEAIFAGGCFWCLEHDLEKLDGVVSAESGYSGGDLINPTYQDHSGHQE
VVKVIFDSDIISYKDLLKQYWVNIDPFDNNGQFCDRGDSYKPVIFTSNQEQKRDAKESQETISVGLNIPLEQLKVDIVES
KVFWLAENYHQDFAVKNPLKYNFYRTSCGRDNRLKKVWGEYKY
>Mature_203_residues
MIAMNKIFRRLIVFSILLQLLIACPLKAFAESEEAIFAGGCFWCLEHDLEKLDGVVSAESGYSGGDLINPTYQDHSGHQE
VVKVIFDSDIISYKDLLKQYWVNIDPFDNNGQFCDRGDSYKPVIFTSNQEQKRDAKESQETISVGLNIPLEQLKVDIVES
KVFWLAENYHQDFAVKNPLKYNFYRTSCGRDNRLKKVWGEYKY

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=35.1851851851852, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI208609995, Length=162, Percent_Identity=35.1851851851852, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI208609993, Length=109, Percent_Identity=33.9449541284404, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=36.1842105263158, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=32.6241134751773, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=30.2816901408451, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23426; Mature: 23426

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAMNKIFRRLIVFSILLQLLIACPLKAFAESEEAIFAGGCFWCLEHDLEKLDGVVSAES
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHHHHHHHHHHCCEEECCC
GYSGGDLINPTYQDHSGHQEVVKVIFDSDIISYKDLLKQYWVNIDPFDNNGQFCDRGDSY
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KPVIFTSNQEQKRDAKESQETISVGLNIPLEQLKVDIVESKVFWLAENYHQDFAVKNPLK
CCEEEECCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YNFYRTSCGRDNRLKKVWGEYKY
EEEEECCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MIAMNKIFRRLIVFSILLQLLIACPLKAFAESEEAIFAGGCFWCLEHDLEKLDGVVSAES
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECHHHHHHHHHHHHHCCEEECCC
GYSGGDLINPTYQDHSGHQEVVKVIFDSDIISYKDLLKQYWVNIDPFDNNGQFCDRGDSY
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
KPVIFTSNQEQKRDAKESQETISVGLNIPLEQLKVDIVESKVFWLAENYHQDFAVKNPLK
CCEEEECCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YNFYRTSCGRDNRLKKVWGEYKY
EEEEECCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]