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The map label for this gene is ispA [C]

Identifier: 124026221

GI number: 124026221

Start: 1228938

End: 1229837

Strand: Reverse

Name: ispA [C]

Synonym: NATL1_15151

Alternate gene names: 124026221

Gene position: 1229837-1228938 (Counterclockwise)

Preceding gene: 124026222

Following gene: 124026220

Centisome position: 65.95

GC content: 43.67

Gene sequence:

>900_bases
ATGCAGGAAGCAATCGCTTCTTTTGACTTCGCTGAGTATCTAGAGAAAGCTAGAACTCGCGTTGAAGATGCGCTGGGTGC
GTCTCTGGGCCCTGAAAAGCCAGAAAAATTAAGGGAATCTATGCGCTATTCCCTTTTGGCGGGAGGGAAGAGATTGAGAC
CAATACTTTGTCTTGCTGCCTGCGAACTCGCTGGAGGCGAACTTGAAAAAGCATTGCCAACAGCAGTTGCTCTGGAAATG
ATTCATACAATGTCTCTTATCCATGATGATCTGCCTTCAATGGATAATGATGATCTTCGTCGAGGGCGTCCAACTAATCA
CAAGGTTTACGGAGATGCGGTGGCCATACTTGCTGGAGATGCTCTATTGACCAGAGCTTTTGAGATGGTGTCAATTCGAA
CAGAGGGAATACCTTCAGAGAGACTATTGAAAATAATTGGTGAGCTTTCTTTAGCGGCAGGGGCTCCTGGGCTAGTGGGA
GGACAAGTAGTTGATCTCGATTGTGAGGGGAAAGAAGTTGATTTAGAAACTTTGGAGTATATTCACCTTCATAAAACAGG
AGCTCTACTTAAGGCATGTGTCACTTGCGGAGCATTGATTGGCGGAGCTGATGAGAAACTCCTAGACGCACTAAGTATCT
ATGCCAGAGGGATTGGATTGGCATTCCAAATAATTGATGACATCCTTGATGTAACAGCAAGTAGTGAAGTATTGGGAAAA
ACGGCAGGAAAGGATTTAATTGCTGATAAGACTACTTACCCCAAATTACTTGGTCTTGATGAATCAAGAAGGAGAGCAGA
TCTTTTAGTAGCTAAAGCAAAAAGTGCTCTTGATCCTTGGCCAGAAAAATCAAAACCTCTTCTTGCATTGGCTGATTACA
TTACAAGTAGAGATAGATGA

Upstream 100 bases:

>100_bases
TGATAGGTGGCAGAAACATTGTGGATTACCTTTAACTATTAGTCATTTACTTCCATGAATCACAATGTCCTGAGAGAATT
GGAAAGAATCGATTTTTTGC

Downstream 100 bases:

>100_bases
ATCTTAATCCAGCTTTCGAATTTCAATTCATTTATATTCTTGATAATGCTGTATTGGCTTGGGGGCTAGCAGCATGTGGT
CTTGCTCAATTTTCTAAATT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MQEAIASFDFAEYLEKARTRVEDALGASLGPEKPEKLRESMRYSLLAGGKRLRPILCLAACELAGGELEKALPTAVALEM
IHTMSLIHDDLPSMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSIRTEGIPSERLLKIIGELSLAAGAPGLVG
GQVVDLDCEGKEVDLETLEYIHLHKTGALLKACVTCGALIGGADEKLLDALSIYARGIGLAFQIIDDILDVTASSEVLGK
TAGKDLIADKTTYPKLLGLDESRRRADLLVAKAKSALDPWPEKSKPLLALADYITSRDR

Sequences:

>Translated_299_residues
MQEAIASFDFAEYLEKARTRVEDALGASLGPEKPEKLRESMRYSLLAGGKRLRPILCLAACELAGGELEKALPTAVALEM
IHTMSLIHDDLPSMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSIRTEGIPSERLLKIIGELSLAAGAPGLVG
GQVVDLDCEGKEVDLETLEYIHLHKTGALLKACVTCGALIGGADEKLLDALSIYARGIGLAFQIIDDILDVTASSEVLGK
TAGKDLIADKTTYPKLLGLDESRRRADLLVAKAKSALDPWPEKSKPLLALADYITSRDR
>Mature_299_residues
MQEAIASFDFAEYLEKARTRVEDALGASLGPEKPEKLRESMRYSLLAGGKRLRPILCLAACELAGGELEKALPTAVALEM
IHTMSLIHDDLPSMDNDDLRRGRPTNHKVYGDAVAILAGDALLTRAFEMVSIRTEGIPSERLLKIIGELSLAAGAPGLVG
GQVVDLDCEGKEVDLETLEYIHLHKTGALLKACVTCGALIGGADEKLLDALSIYARGIGLAFQIIDDILDVTASSEVLGK
TAGKDLIADKTTYPKLLGLDESRRRADLLVAKAKSALDPWPEKSKPLLALADYITSRDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=236, Percent_Identity=31.3559322033898, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786623, Length=299, Percent_Identity=46.1538461538462, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=33.4883720930233, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=280, Percent_Identity=27.5, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651612, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32190; Mature: 32190

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEAIASFDFAEYLEKARTRVEDALGASLGPEKPEKLRESMRYSLLAGGKRLRPILCLAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
CELAGGELEKALPTAVALEMIHTMSLIHDDLPSMDNDDLRRGRPTNHKVYGDAVAILAGD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEHHCCHHHHHHH
ALLTRAFEMVSIRTEGIPSERLLKIIGELSLAAGAPGLVGGQVVDLDCEGKEVDLETLEY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHH
IHLHKTGALLKACVTCGALIGGADEKLLDALSIYARGIGLAFQIIDDILDVTASSEVLGK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAGKDLIADKTTYPKLLGLDESRRRADLLVAKAKSALDPWPEKSKPLLALADYITSRDR
HCCCHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQEAIASFDFAEYLEKARTRVEDALGASLGPEKPEKLRESMRYSLLAGGKRLRPILCLAA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
CELAGGELEKALPTAVALEMIHTMSLIHDDLPSMDNDDLRRGRPTNHKVYGDAVAILAGD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEHHCCHHHHHHH
ALLTRAFEMVSIRTEGIPSERLLKIIGELSLAAGAPGLVGGQVVDLDCEGKEVDLETLEY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHH
IHLHKTGALLKACVTCGALIGGADEKLLDALSIYARGIGLAFQIIDDILDVTASSEVLGK
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TAGKDLIADKTTYPKLLGLDESRRRADLLVAKAKSALDPWPEKSKPLLALADYITSRDR
HCCCHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]