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The map label for this gene is umuC [H]

Identifier: 124025650

GI number: 124025650

Start: 870671

End: 871948

Strand: Reverse

Name: umuC [H]

Synonym: NATL1_09431

Alternate gene names: 124025650

Gene position: 871948-870671 (Counterclockwise)

Preceding gene: 124025651

Following gene: 124025649

Centisome position: 46.76

GC content: 31.14

Gene sequence:

>1278_bases
ATGTCCAAAGTAATACTTCAAATTGATGGGAATAATTTCTATGCTTCGTGTGAACAAATGATCGATCCTTCCATAAAAGG
AAAGGGATTAGTAGTACTTTCGAATAATGATGGATGCATAATAGCTCGCAGTTCAGAGGCCAGAAGAATGGGAATTCCTA
TGGGACAGCCTTATTTCAAGTTAAAGAATAAACTAACTCAATTAAATATAAATGTGAGAAGTTCAAATTACGAATTGTAC
GGTGATATAAGTAATCGATTAATGCAACTACTAAGAAAAAATTGTGAAGAACTGGAAATTTACTCTATAGATGAAGCGTT
TGGAACTATAAAACGTCCAAAGGAAAAGTGCTTATACAAATGGGGAAAAGATTTAAGGGCTTTGGTTTATCAAAACATAG
GAATACCAATATCTATTGGTATTGGTGAGACAAAAGTTCTATCAAAAATTTCTAATCATCTAGCAAAAAAGATACAAACG
AATTCAGGTATATTTGATATAGGTCTTGTTGAAAATAAAGATCATTATCTTGATCTAATTAAAGTAGATAAAGTTTGGGG
TATCGGCAAAAGGATGTCTAAATGGCTAAAAGACAGAGGCATCACTAATGCGAGAGAACTTAGAGATATGTCAAGCGACC
AAATCAAAGGAAAGTATGGTGTAGTTGGTCTACGCATTCAAAATGAATTAAAAGGAAACCTCTGTATCCCTATAAAAGAG
AACTCATCAGATCGAAAAGAAATCTGCGTAAGCAGGAGTTTTGCACATCCCATAGATAGCTTAGATGATTTGAGCCAAGC
AATTATTAAATACGTTTTAATCGCAAGTGCTAAGTTGCGAAAATATAATCAATTATCTTCAGCTATTACGCTTTTTACGA
ATACAAATACTCATTCAAAAGATTTTTTCAGGAGTGAAGCAACAGCAAAAATAAGCGTTCCAACTTCTAACTCAAAGATC
ATGATTGAAAAAAGTCTATCACTAACAAAAGAAATTTTTAAACCATATAAAAAATTTATAAAAGCAGGTGTAATATTGCA
TAAACTTCAAAGCAATCAATATAAACAAAACCTAATATTTGATGCACAGAATATTAAAGAAGAATTATACTTACAGAGAC
TGGATAATGTAATAGATAATATTAACTCGAAAAATGGTATAGATACAATAAATTGGGGATCATCAATGATGGATACAGAA
TGGAGACCCCGAAGAAAAAATCTATCTAGTATAAAAACAACAAATATAGAAAATATTCCAACTATATATGCTAATTAG

Upstream 100 bases:

>100_bases
AAAATTATCCAGCAATAAACTTATATGAATATATAGATATCCAAATATGGGGAGTAGCGATTTATTCGATACATGAACTA
CAACAATCAAAAGTATAATT

Downstream 100 bases:

>100_bases
AAGTTAGTATAATATTTAACAATGATGCTACATATTAAAATTCAAACTGAGTGTCATGCTACATTCAAAAGAATAGAAGT
CCTAGAAAAAATATAGTGGA

Product: putative UmuC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSKVILQIDGNNFYASCEQMIDPSIKGKGLVVLSNNDGCIIARSSEARRMGIPMGQPYFKLKNKLTQLNINVRSSNYELY
GDISNRLMQLLRKNCEELEIYSIDEAFGTIKRPKEKCLYKWGKDLRALVYQNIGIPISIGIGETKVLSKISNHLAKKIQT
NSGIFDIGLVENKDHYLDLIKVDKVWGIGKRMSKWLKDRGITNARELRDMSSDQIKGKYGVVGLRIQNELKGNLCIPIKE
NSSDRKEICVSRSFAHPIDSLDDLSQAIIKYVLIASAKLRKYNQLSSAITLFTNTNTHSKDFFRSEATAKISVPTSNSKI
MIEKSLSLTKEIFKPYKKFIKAGVILHKLQSNQYKQNLIFDAQNIKEELYLQRLDNVIDNINSKNGIDTINWGSSMMDTE
WRPRRKNLSSIKTTNIENIPTIYAN

Sequences:

>Translated_425_residues
MSKVILQIDGNNFYASCEQMIDPSIKGKGLVVLSNNDGCIIARSSEARRMGIPMGQPYFKLKNKLTQLNINVRSSNYELY
GDISNRLMQLLRKNCEELEIYSIDEAFGTIKRPKEKCLYKWGKDLRALVYQNIGIPISIGIGETKVLSKISNHLAKKIQT
NSGIFDIGLVENKDHYLDLIKVDKVWGIGKRMSKWLKDRGITNARELRDMSSDQIKGKYGVVGLRIQNELKGNLCIPIKE
NSSDRKEICVSRSFAHPIDSLDDLSQAIIKYVLIASAKLRKYNQLSSAITLFTNTNTHSKDFFRSEATAKISVPTSNSKI
MIEKSLSLTKEIFKPYKKFIKAGVILHKLQSNQYKQNLIFDAQNIKEELYLQRLDNVIDNINSKNGIDTINWGSSMMDTE
WRPRRKNLSSIKTTNIENIPTIYAN
>Mature_424_residues
SKVILQIDGNNFYASCEQMIDPSIKGKGLVVLSNNDGCIIARSSEARRMGIPMGQPYFKLKNKLTQLNINVRSSNYELYG
DISNRLMQLLRKNCEELEIYSIDEAFGTIKRPKEKCLYKWGKDLRALVYQNIGIPISIGIGETKVLSKISNHLAKKIQTN
SGIFDIGLVENKDHYLDLIKVDKVWGIGKRMSKWLKDRGITNARELRDMSSDQIKGKYGVVGLRIQNELKGNLCIPIKEN
SSDRKEICVSRSFAHPIDSLDDLSQAIIKYVLIASAKLRKYNQLSSAITLFTNTNTHSKDFFRSEATAKISVPTSNSKIM
IEKSLSLTKEIFKPYKKFIKAGVILHKLQSNQYKQNLIFDAQNIKEELYLQRLDNVIDNINSKNGIDTINWGSSMMDTEW
RPRRKNLSSIKTTNIENIPTIYAN

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=415, Percent_Identity=35.421686746988, Blast_Score=256, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 48387; Mature: 48255

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVILQIDGNNFYASCEQMIDPSIKGKGLVVLSNNDGCIIARSSEARRMGIPMGQPYFK
CCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCHHCCCCCCCHHHH
LKNKLTQLNINVRSSNYELYGDISNRLMQLLRKNCEELEIYSIDEAFGTIKRPKEKCLYK
HHCCEEEEEEEEECCCEEEEEHHHHHHHHHHHCCCHHEEEEEEHHHHHHHCCHHHHHHHH
WGKDLRALVYQNIGIPISIGIGETKVLSKISNHLAKKIQTNSGIFDIGLVENKDHYLDLI
HCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
KVDKVWGIGKRMSKWLKDRGITNARELRDMSSDQIKGKYGVVGLRIQNELKGNLCIPIKE
EEHHHHCCHHHHHHHHHHCCCCCHHHHHCCCCHHCCCCCCEEEEEEECCCCCCEEEEECC
NSSDRKEICVSRSFAHPIDSLDDLSQAIIKYVLIASAKLRKYNQLSSAITLFTNTNTHSK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCH
DFFRSEATAKISVPTSNSKIMIEKSLSLTKEIFKPYKKFIKAGVILHKLQSNQYKQNLIF
HHHHCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEE
DAQNIKEELYLQRLDNVIDNINSKNGIDTINWGSSMMDTEWRPRRKNLSSIKTTNIENIP
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCC
TIYAN
EEECC
>Mature Secondary Structure 
SKVILQIDGNNFYASCEQMIDPSIKGKGLVVLSNNDGCIIARSSEARRMGIPMGQPYFK
CEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCHHCCCCCCCHHHH
LKNKLTQLNINVRSSNYELYGDISNRLMQLLRKNCEELEIYSIDEAFGTIKRPKEKCLYK
HHCCEEEEEEEEECCCEEEEEHHHHHHHHHHHCCCHHEEEEEEHHHHHHHCCHHHHHHHH
WGKDLRALVYQNIGIPISIGIGETKVLSKISNHLAKKIQTNSGIFDIGLVENKDHYLDLI
HCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEE
KVDKVWGIGKRMSKWLKDRGITNARELRDMSSDQIKGKYGVVGLRIQNELKGNLCIPIKE
EEHHHHCCHHHHHHHHHHCCCCCHHHHHCCCCHHCCCCCCEEEEEEECCCCCCEEEEECC
NSSDRKEICVSRSFAHPIDSLDDLSQAIIKYVLIASAKLRKYNQLSSAITLFTNTNTHSK
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCH
DFFRSEATAKISVPTSNSKIMIEKSLSLTKEIFKPYKKFIKAGVILHKLQSNQYKQNLIF
HHHHCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEE
DAQNIKEELYLQRLDNVIDNINSKNGIDTINWGSSMMDTEWRPRRKNLSSIKTTNIENIP
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCC
TIYAN
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]