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The map label for this gene is thyX [H]

Identifier: 124025034

GI number: 124025034

Start: 298907

End: 299545

Strand: Reverse

Name: thyX [H]

Synonym: NATL1_03211

Alternate gene names: 124025034

Gene position: 299545-298907 (Counterclockwise)

Preceding gene: 124025035

Following gene: 124025031

Centisome position: 16.06

GC content: 33.65

Gene sequence:

>639_bases
ATGAGTCGTGTTCAATTAATAACCTCTACGCCAAACGCTGAAAAAAGCATGGCATATATTGCCAGGGTTAGCAATCCAAA
GAATCAGGATAATGATGACTTTACGAAATTAATTGGGTATTGCATTAAGAACGAACATTGGAGCGTATTTGAGCAAGCTT
ATATGACTTTGCAAATAGAAACTACTCGAGGAATTGCTGCACAAATTTTAAGACATCGATCATTTACCTTTCAAGAATTT
TCTCAACGCTATGCAGATAGCATGCAATTAGGAGAAATTCCTATACCAGAATTAAGAAGACAAGATAATAAAAATAGACA
AAATTCTATATCAGACTTGCCAAAAGAAATTATTAATACTTTCAACAAAAAAATAAAACATCAGTTTGTTCAAAATAAAG
AGCTTTATGAAGAGATGTTAGAAGCTGGAATCGCCAAAGAATGTGCAAGATTTGTACTTCCACTTGCTACCCCAACCAGA
ATTTATATGACAGGATCATGTCGTTCCTGGATTCATTACATAAATCTTAGAACTGGTCATGGCACGCAAAAAGAGCATAT
GGAGATTGCACAAGAATGTAAAAATATTTTTTCAAAAGAATATCCAGTAGTTTCATCTGCTTTGAATTGGCTATTCTAG

Upstream 100 bases:

>100_bases
TACTCTTCTTTGAAGGAGATCCTTGTGAAACAACTTACAGTGATAGGAAAGGTAAATATCAATATCAACAAGAAAAAGTA
ACCCTAGCAAAGGTTTAAAT

Downstream 100 bases:

>100_bases
CTATGATCCCTTGGGCCTTCTGATCTAATATTATTATCTAGAACTTTTAAATTATTTTTAGAAATTAAATTACTTGAATT
TGATAATTTTGTGAAAGCGG

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSRVQLITSTPNAEKSMAYIARVSNPKNQDNDDFTKLIGYCIKNEHWSVFEQAYMTLQIETTRGIAAQILRHRSFTFQEF
SQRYADSMQLGEIPIPELRRQDNKNRQNSISDLPKEIINTFNKKIKHQFVQNKELYEEMLEAGIAKECARFVLPLATPTR
IYMTGSCRSWIHYINLRTGHGTQKEHMEIAQECKNIFSKEYPVVSSALNWLF

Sequences:

>Translated_212_residues
MSRVQLITSTPNAEKSMAYIARVSNPKNQDNDDFTKLIGYCIKNEHWSVFEQAYMTLQIETTRGIAAQILRHRSFTFQEF
SQRYADSMQLGEIPIPELRRQDNKNRQNSISDLPKEIINTFNKKIKHQFVQNKELYEEMLEAGIAKECARFVLPLATPTR
IYMTGSCRSWIHYINLRTGHGTQKEHMEIAQECKNIFSKEYPVVSSALNWLF
>Mature_211_residues
SRVQLITSTPNAEKSMAYIARVSNPKNQDNDDFTKLIGYCIKNEHWSVFEQAYMTLQIETTRGIAAQILRHRSFTFQEFS
QRYADSMQLGEIPIPELRRQDNKNRQNSISDLPKEIINTFNKKIKHQFVQNKELYEEMLEAGIAKECARFVLPLATPTRI
YMTGSCRSWIHYINLRTGHGTQKEHMEIAQECKNIFSKEYPVVSSALNWLF

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 24759; Mature: 24627

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVQLITSTPNAEKSMAYIARVSNPKNQDNDDFTKLIGYCIKNEHWSVFEQAYMTLQIE
CCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEE
TTRGIAAQILRHRSFTFQEFSQRYADSMQLGEIPIPELRRQDNKNRQNSISDLPKEIINT
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
FNKKIKHQFVQNKELYEEMLEAGIAKECARFVLPLATPTRIYMTGSCRSWIHYINLRTGH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCC
GTQKEHMEIAQECKNIFSKEYPVVSSALNWLF
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
SRVQLITSTPNAEKSMAYIARVSNPKNQDNDDFTKLIGYCIKNEHWSVFEQAYMTLQIE
CCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEE
TTRGIAAQILRHRSFTFQEFSQRYADSMQLGEIPIPELRRQDNKNRQNSISDLPKEIINT
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
FNKKIKHQFVQNKELYEEMLEAGIAKECARFVLPLATPTRIYMTGSCRSWIHYINLRTGH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCC
GTQKEHMEIAQECKNIFSKEYPVVSSALNWLF
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]