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The map label for this gene is menA [H]

Identifier: 124024964

GI number: 124024964

Start: 231820

End: 232809

Strand: Reverse

Name: menA [H]

Synonym: NATL1_02511

Alternate gene names: 124024964

Gene position: 232809-231820 (Counterclockwise)

Preceding gene: 124024966

Following gene: 124024963

Centisome position: 12.48

GC content: 36.87

Gene sequence:

>990_bases
ATGCATGAACTGCTGCCTAGTCTTAAGGGATACACCAAGAAACAAACAGGAAGGATTAGTTTATCAGTGAAGTCTTCTAC
AACTGAAAGAAAACATCTTTGGCAAGCTGCAATTAAGTGGCCACTGTATTCAGTCGCAATAATGCCCGTAATTGTATCTG
CAGGATGGGAGCTAGGAAATAGCGGCAATATTCGTCTGGGACAATTCATCGGTTTTCTAATTGCCTCAATCTTGATCTTG
CTTTGGGAAAACCTTACCAATGATCTTTTTGACGATGAAACTGGTGTTGACAAATACAAATTCCACTCGGTAGTAGCTTT
AACTGGTAGTAAAAGCACTGTAAGTCGAGTTGCATATTTTTCTCTTTTATTAGGTTTATTTATAATATTTATCCTCGCTC
TAAAAAGTAAAATAACAGTACTTTTTTTAGTCATAATTTGTTGTTTCCTTGGATATTTATATCAAGGGCCACCATTTAGA
CTGGGGTATAAGGGGCTGGGAGAACCCCTTTGCTGGATTGCATTTGGACCACTTGCAACAGCTGCAGCACTAATTGTTAT
TTCTCCAAAATCTAATTTTGATACCATCCCCTGGGGAACTGCACTAATTGTTGGAGCAGGTCCCGCCATGGCGACCACTT
TAGTTCTATTCTGTTCGCATTTTCATCAAATCAATCAAGATGCTGCTGTCGGTAAAAAATCACCCTTAGTTATTTTAGGC
ACTCATCGAGCGGCAGAATTTTTACCGTGGTTCGTTGGTCTAATATTATTATTAGAATTACTACCTGTACTACTTGGAAT
ATGGCCAATAACGACTCTTATATGTTTAATTAGCCTTCCTTCAGGATTAGATCTTATTAAATTAATTAAAAGACATCACA
ACCAACCTGAGCGTATTAAAAACAGTAAGTTTTTAGCTTTACGCTTTCAGACAATTAATGGTTTATGCTTGAGTATAGGT
TTTGCTATATCCTCATTTTTTTATAATTAA

Upstream 100 bases:

>100_bases
CTTTTCTTACACTCCATTTCTGAAGAGAACTAACTAAAAGCTCACTAAAGACGGGTTCTAAATTCATAACCAATTAGACC
CTTTATAAATAAATAAACCA

Downstream 100 bases:

>100_bases
TTTTTGATTTTATTGAATCATGAAATTAATAATTAATATCAAGCCATTTTCATTTCAACTAACAAGAAAGTTAATAACCT
CGCAAGGAATTATTCATAAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MHELLPSLKGYTKKQTGRISLSVKSSTTERKHLWQAAIKWPLYSVAIMPVIVSAGWELGNSGNIRLGQFIGFLIASILIL
LWENLTNDLFDDETGVDKYKFHSVVALTGSKSTVSRVAYFSLLLGLFIIFILALKSKITVLFLVIICCFLGYLYQGPPFR
LGYKGLGEPLCWIAFGPLATAAALIVISPKSNFDTIPWGTALIVGAGPAMATTLVLFCSHFHQINQDAAVGKKSPLVILG
THRAAEFLPWFVGLILLLELLPVLLGIWPITTLICLISLPSGLDLIKLIKRHHNQPERIKNSKFLALRFQTINGLCLSIG
FAISSFFYN

Sequences:

>Translated_329_residues
MHELLPSLKGYTKKQTGRISLSVKSSTTERKHLWQAAIKWPLYSVAIMPVIVSAGWELGNSGNIRLGQFIGFLIASILIL
LWENLTNDLFDDETGVDKYKFHSVVALTGSKSTVSRVAYFSLLLGLFIIFILALKSKITVLFLVIICCFLGYLYQGPPFR
LGYKGLGEPLCWIAFGPLATAAALIVISPKSNFDTIPWGTALIVGAGPAMATTLVLFCSHFHQINQDAAVGKKSPLVILG
THRAAEFLPWFVGLILLLELLPVLLGIWPITTLICLISLPSGLDLIKLIKRHHNQPERIKNSKFLALRFQTINGLCLSIG
FAISSFFYN
>Mature_329_residues
MHELLPSLKGYTKKQTGRISLSVKSSTTERKHLWQAAIKWPLYSVAIMPVIVSAGWELGNSGNIRLGQFIGFLIASILIL
LWENLTNDLFDDETGVDKYKFHSVVALTGSKSTVSRVAYFSLLLGLFIIFILALKSKITVLFLVIICCFLGYLYQGPPFR
LGYKGLGEPLCWIAFGPLATAAALIVISPKSNFDTIPWGTALIVGAGPAMATTLVLFCSHFHQINQDAAVGKKSPLVILG
THRAAEFLPWFVGLILLLELLPVLLGIWPITTLICLISLPSGLDLIKLIKRHHNQPERIKNSKFLALRFQTINGLCLSIG
FAISSFFYN

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 36287; Mature: 36287

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELLPSLKGYTKKQTGRISLSVKSSTTERKHLWQAAIKWPLYSVAIMPVIVSAGWELGN
CCHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGNIRLGQFIGFLIASILILLWENLTNDLFDDETGVDKYKFHSVVALTGSKSTVSRVAYF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEECCHHHHHHHHHH
SLLLGLFIIFILALKSKITVLFLVIICCFLGYLYQGPPFRLGYKGLGEPLCWIAFGPLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHEEHHHHHH
AAALIVISPKSNFDTIPWGTALIVGAGPAMATTLVLFCSHFHQINQDAAVGKKSPLVILG
HEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEE
THRAAEFLPWFVGLILLLELLPVLLGIWPITTLICLISLPSGLDLIKLIKRHHNQPERIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHC
NSKFLALRFQTINGLCLSIGFAISSFFYN
CCCEEEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHELLPSLKGYTKKQTGRISLSVKSSTTERKHLWQAAIKWPLYSVAIMPVIVSAGWELGN
CCHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SGNIRLGQFIGFLIASILILLWENLTNDLFDDETGVDKYKFHSVVALTGSKSTVSRVAYF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEECCHHHHHHHHHH
SLLLGLFIIFILALKSKITVLFLVIICCFLGYLYQGPPFRLGYKGLGEPLCWIAFGPLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHEEHHHHHH
AAALIVISPKSNFDTIPWGTALIVGAGPAMATTLVLFCSHFHQINQDAAVGKKSPLVILG
HEEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEE
THRAAEFLPWFVGLILLLELLPVLLGIWPITTLICLISLPSGLDLIKLIKRHHNQPERIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHC
NSKFLALRFQTINGLCLSIGFAISSFFYN
CCCEEEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]