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The map label for this gene is 124024961

Identifier: 124024961

GI number: 124024961

Start: 229148

End: 229600

Strand: Direct

Name: 124024961

Synonym: NATL1_02481

Alternate gene names: NA

Gene position: 229148-229600 (Clockwise)

Preceding gene: 124024960

Following gene: 124024965

Centisome position: 12.29

GC content: 33.55

Gene sequence:

>453_bases
TTGGAAAAGCGTAATCCTAGAGAATGGTTATGTTTGAATCGAACAGTTCGTTTTGGTGAGACAGATGCTGCTGGTGTGGT
GCATTTCGTTGAATTGTTCAGATGGTGTCATGAAACTTGGGAAGAAAGCTTAGAAAAATTTGGAATAGTTTTAAAAGAAA
TTTTCCCTTCAACCCAAATCAATACAAGCCAACTGGATGTAGCTTTACCAGTTGTTCATTGTGAAGCAAATTACTTTCAA
CCACTTTATGTGGGAGATACTATCAATATCGAACTGTATCCAGAGAAGATAAATGAGTCTTCATTTGTACTTCTATTTAA
ATTTAAAAAGAATGGTGAGCAAATCGGTACGACAAATATAAAACATGTATCAATAAATCCGATTACAAGAGAAAAATGTG
CATTATCTAAACAAATAAATTTGTGGCTTCATGAATCTGGCTTGAATTTTTAG

Upstream 100 bases:

>100_bases
AGATACTTCCTCACATACTTAAGGGAGCTAAGGTTGCTGACATAATGGCTATATTAGGTTCGATCGATGTGATTATGGGT
TCTGTTGATAGATAGGTCTT

Downstream 100 bases:

>100_bases
CTGATAGGACTATTCAAGGCTACCCAATCTTGCCATTTTTTTACTTCCCATTTTTTATTGATATTTCGTGAAAGTTTTGG
ACAGTCGTACCATTTTAGTG

Product: thioesterase

Products: NA

Alternate protein names: DHNA-CoA hydrolase; DHNA-CoA thioesterase

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MEKRNPREWLCLNRTVRFGETDAAGVVHFVELFRWCHETWEESLEKFGIVLKEIFPSTQINTSQLDVALPVVHCEANYFQ
PLYVGDTINIELYPEKINESSFVLLFKFKKNGEQIGTTNIKHVSINPITREKCALSKQINLWLHESGLNF

Sequences:

>Translated_150_residues
MEKRNPREWLCLNRTVRFGETDAAGVVHFVELFRWCHETWEESLEKFGIVLKEIFPSTQINTSQLDVALPVVHCEANYFQ
PLYVGDTINIELYPEKINESSFVLLFKFKKNGEQIGTTNIKHVSINPITREKCALSKQINLWLHESGLNF
>Mature_150_residues
MEKRNPREWLCLNRTVRFGETDAAGVVHFVELFRWCHETWEESLEKFGIVLKEIFPSTQINTSQLDVALPVVHCEANYFQ
PLYVGDTINIELYPEKINESSFVLLFKFKKNGEQIGTTNIKHVSINPITREKCALSKQINLWLHESGLNF

Specific function: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis

COG id: COG0824

COG function: function code R; Predicted thioesterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNCH_PROM1 (A2C002)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014077.1
- ProteinModelPortal:   A2C002
- SMR:   A2C002
- STRING:   A2C002
- GeneID:   4779701
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_02481
- eggNOG:   COG0824
- HOGENOM:   HBG439376
- OMA:   HEAWEES
- ProtClustDB:   CLSK840004
- BioCyc:   PMAR167555:NATL1_02481-MONOMER
- HAMAP:   MF_02101
- InterPro:   IPR022829
- InterPro:   IPR006683

Pfam domain/function: PF03061 4HBT

EC number: =3.1.2.28

Molecular weight: Translated: 17456; Mature: 17456

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS01328 4HBCOA_THIOESTERASE

Important sites: ACT_SITE 22-22

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRNPREWLCLNRTVRFGETDAAGVVHFVELFRWCHETWEESLEKFGIVLKEIFPSTQI
CCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTSQLDVALPVVHCEANYFQPLYVGDTINIELYPEKINESSFVLLFKFKKNGEQIGTTNI
CCCCEEEEEEEEEECCCCCCEEEECCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCE
KHVSINPITREKCALSKQINLWLHESGLNF
EEEEECCCCHHHHHHHHHEEEEEECCCCCC
>Mature Secondary Structure
MEKRNPREWLCLNRTVRFGETDAAGVVHFVELFRWCHETWEESLEKFGIVLKEIFPSTQI
CCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTSQLDVALPVVHCEANYFQPLYVGDTINIELYPEKINESSFVLLFKFKKNGEQIGTTNI
CCCCEEEEEEEEEECCCCCCEEEECCEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCE
KHVSINPITREKCALSKQINLWLHESGLNF
EEEEECCCCHHHHHHHHHEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA