Click here to switch to the map view.

The map label for this gene is ndhH [H]

Identifier: 124024960

GI number: 124024960

Start: 227958

End: 229142

Strand: Direct

Name: ndhH [H]

Synonym: NATL1_02471

Alternate gene names: 124024960

Gene position: 227958-229142 (Clockwise)

Preceding gene: 124024958

Following gene: 124024961

Centisome position: 12.22

GC content: 40.17

Gene sequence:

>1185_bases
ATGGCGCAGCTTGAAACGCGTACGGAGCCAATGGTGGTCAACTTTGGGCCACATCATCCATCAATGCATGGGGTGTTGCG
ATTGGTCGTAACCCTTGATGGAGAGGATGTTGTTGATTGTGAACCAGTTATTGGTTACTTGCATCGAGGGATGGAGAAAA
TTGCTGAGAATAGAACAAACGTCATGTTTGTTCCATACGTAAGCCGTATGGATTATGCGGCTGGTATGTTTTATGAAGCC
ATTGTTGTTAATGCCCCTGAGCGTTTAGCAAATATAAAGGTACCCAAGAGAGCAAGTTATATCAGAGCGATAATGCTTGA
GTTGAATAGGATCGCTAACCATTTACTATGGTTAGGCCCATTTTTGGCTGATGTAGGAGCGCAAACTCCTTTCTTCTATA
TTTTTAGAGAAAGAGAGATGATTTACGATTTATGGGAGGCTGCAACTGGTCAAAGATTGATTAATAATAATTATTTCCGT
ATTGGAGGCGTTGCATGTGATTTACCTTGGGGCTGGTTAGAAAAATGCAAAGATTTTTGTGACTGGTTTGGTCCCAAAAT
TGATGAGTATGAAAAATTGATAACCAATAACCCTATTTTTCGTAGACGTATAGAAGGTTTAGGAGTCATAGGAAAAGAAC
AAGCGATTAACTGGAGCCTTTCTGGCCCAATGCTTCGGGCAGCGGGTGTTCCATGGGATTTGAGAAAAGTAGATCACTAT
GAATGTTATGACGATTTTGAATGGGATATTGCATGGGAGAAAGAGGGAGATTGTTATGCAAGATATAGAGTTCGTATTGA
AGAAATGAGACAGTCATTGAAAATATTACGACAAGCCTGTGAGATGATTCCTGGGGGGCCAACAGAAAATCTTGAGGCAC
AAAGAACAGTTGAGGGAAAAAAAGGTGATTTGTCGGGGTTTGATTATCAATATGTAGCCAAGAAAGTGGCACCTACTTTT
AAGATCCCTAATGGTGAATTATATACACGTCTTGAGTCTGGCAAAGGTGAAATAGGGGTATTTATTCAAGGTAATAACGA
TGTAACTCCTTGGCGGTTTAAAATTAGAGCAGCTGATTCTAATAATTTGCAGATACTTCCTCACATACTTAAGGGAGCTA
AGGTTGCTGACATAATGGCTATATTAGGTTCGATCGATGTGATTATGGGTTCTGTTGATAGATAG

Upstream 100 bases:

>100_bases
TTCCCCATTACAGGGACATGATTAAAGTTAGAACTTGAACTAATTGGCCCTTCTTTCATAAGTTTTCACTAGTATTTAGA
CATTGCTTTGTTTTGGCCCA

Downstream 100 bases:

>100_bases
GTCTTTTGGAAAAGCGTAATCCTAGAGAATGGTTATGTTTGAATCGAACAGTTCGTTTTGGTGAGACAGATGCTGCTGGT
GTGGTGCATTTCGTTGAATT

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTNVMFVPYVSRMDYAAGMFYEA
IVVNAPERLANIKVPKRASYIRAIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFR
IGGVACDLPWGWLEKCKDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGVIGKEQAINWSLSGPMLRAAGVPWDLRKVDHY
ECYDDFEWDIAWEKEGDCYARYRVRIEEMRQSLKILRQACEMIPGGPTENLEAQRTVEGKKGDLSGFDYQYVAKKVAPTF
KIPNGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADSNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR

Sequences:

>Translated_394_residues
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTNVMFVPYVSRMDYAAGMFYEA
IVVNAPERLANIKVPKRASYIRAIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFR
IGGVACDLPWGWLEKCKDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGVIGKEQAINWSLSGPMLRAAGVPWDLRKVDHY
ECYDDFEWDIAWEKEGDCYARYRVRIEEMRQSLKILRQACEMIPGGPTENLEAQRTVEGKKGDLSGFDYQYVAKKVAPTF
KIPNGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADSNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
>Mature_393_residues
AQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTNVMFVPYVSRMDYAAGMFYEAI
VVNAPERLANIKVPKRASYIRAIMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRI
GGVACDLPWGWLEKCKDFCDWFGPKIDEYEKLITNNPIFRRRIEGLGVIGKEQAINWSLSGPMLRAAGVPWDLRKVDHYE
CYDDFEWDIAWEKEGDCYARYRVRIEEMRQSLKILRQACEMIPGGPTENLEAQRTVEGKKGDLSGFDYQYVAKKVAPTFK
IPNGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADSNNLQILPHILKGAKVADIMAILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=393, Percent_Identity=39.9491094147583, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI260898743, Length=387, Percent_Identity=39.2764857881137, Blast_Score=281, Evalue=8e-76,
Organism=Escherichia coli, GI145693162, Length=388, Percent_Identity=38.659793814433, Blast_Score=287, Evalue=8e-79,
Organism=Escherichia coli, GI1789076, Length=387, Percent_Identity=29.9741602067183, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=27.2264631043257, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=39.3401015228426, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=39.030612244898, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=39.5939086294416, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=40.1041666666667, Blast_Score=310, Evalue=9e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: 1.6.5.3

Molecular weight: Translated: 45064; Mature: 44932

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTN
CCCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
VMFVPYVSRMDYAAGMFYEAIVVNAPERLANIKVPKRASYIRAIMLELNRIANHLLWLGP
EEEEECHHHHHHHHHHHHHHHEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPWGWLEKCKDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFRRRIEGLGVIGKEQAINWSLSGPMLRAAGVPWDLRKVDHY
HHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCHHHHCCCCC
ECYDDFEWDIAWEKEGDCYARYRVRIEEMRQSLKILRQACEMIPGGPTENLEAQRTVEGK
CCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
KGDLSGFDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADS
CCCCCCCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCC
NNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
CCCEEHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGEDVVDCEPVIGYLHRGMEKIAENRTN
CCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
VMFVPYVSRMDYAAGMFYEAIVVNAPERLANIKVPKRASYIRAIMLELNRIANHLLWLGP
EEEEECHHHHHHHHHHHHHHHEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNYFRIGGVACDLPWGWLEKCKDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFRRRIEGLGVIGKEQAINWSLSGPMLRAAGVPWDLRKVDHY
HHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHCCCCHHHHCCCCC
ECYDDFEWDIAWEKEGDCYARYRVRIEEMRQSLKILRQACEMIPGGPTENLEAQRTVEGK
CCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
KGDLSGFDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFIQGNNDVTPWRFKIRAADS
CCCCCCCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECCC
NNLQILPHILKGAKVADIMAILGSIDVIMGSVDR
CCCEEHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA