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The map label for this gene is lexA [H]

Identifier: 124023614

GI number: 124023614

Start: 1681431

End: 1682027

Strand: Reverse

Name: lexA [H]

Synonym: P9303_19141

Alternate gene names: 124023614

Gene position: 1682027-1681431 (Counterclockwise)

Preceding gene: 124023615

Following gene: 124023606

Centisome position: 62.7

GC content: 57.62

Gene sequence:

>597_bases
TTGCTTACTTCTGCCCAGCAGGAGCTTTATGACTGGTTGGCCGATTACATCGGCAGCCATCACCACAGCCCTTCGATTCG
ACAGATGATGCAGGCCATGGGTCTGCGCTCACCAGCGCCGGTGCAGAGCCGGCTTCGACATTTGCAGCAGAAGGGATGGA
TTACTTGGCAGGAAGGGCAGGCGCGTACCTTGCAGCTGCTTGGTGGGTTGGTGTCCGGTATTCCCGTGTTGGGGGCAGTC
GCCGCTGGTGGTTTGGTGGAGACGTTTGATGATGTTCAGGAGCGGTTAGATCTTGCACCAGTTTTGGAGACCCGTGGCCT
GTTTGCGCTCACCGTGAATGGAGATTCGATGGTGGATGCCTACATTGCAGATGGCGATGTGGTTCTGATGGAGCCAGTAT
CTGAGCCTTCGAGGCTGCGAGATGGAACTGTGGTGAGTGCACTTGTTCCCGGAAGTGGCACCACGCTGAAGCACTTTCAC
CGCAACGGCGCCTCGGTGCGGCTTGAGGCCGCTAATACCGCCTATGAGCCGATTGAGCTACCAGCCGATCAAGTGCAGGT
GCAGGGCAAGCTGGTGGCTGTTTGGCGTCAGGTTTGA

Upstream 100 bases:

>100_bases
CTGCACTGTTTGGTGTTTAAACCCTTGCCAGATCCAGCGCCCATAGGTACACATGTATTGACGAATCTATGCATTGCCGT
TGGCTGCCTCTTCTCCTGAG

Downstream 100 bases:

>100_bases
GGCCTTGCCGTTGTAAGCTCTGTTTTGACGGCGGTACGAGCCCAGTGTTACCGGCGTTTATGGGGCCATAGCTCAGCTGG
TAGAGCACCTGCATGGCATG

Product: SOS function regulatory protein, LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MLTSAQQELYDWLADYIGSHHHSPSIRQMMQAMGLRSPAPVQSRLRHLQQKGWITWQEGQARTLQLLGGLVSGIPVLGAV
AAGGLVETFDDVQERLDLAPVLETRGLFALTVNGDSMVDAYIADGDVVLMEPVSEPSRLRDGTVVSALVPGSGTTLKHFH
RNGASVRLEAANTAYEPIELPADQVQVQGKLVAVWRQV

Sequences:

>Translated_198_residues
MLTSAQQELYDWLADYIGSHHHSPSIRQMMQAMGLRSPAPVQSRLRHLQQKGWITWQEGQARTLQLLGGLVSGIPVLGAV
AAGGLVETFDDVQERLDLAPVLETRGLFALTVNGDSMVDAYIADGDVVLMEPVSEPSRLRDGTVVSALVPGSGTTLKHFH
RNGASVRLEAANTAYEPIELPADQVQVQGKLVAVWRQV
>Mature_198_residues
MLTSAQQELYDWLADYIGSHHHSPSIRQMMQAMGLRSPAPVQSRLRHLQQKGWITWQEGQARTLQLLGGLVSGIPVLGAV
AAGGLVETFDDVQERLDLAPVLETRGLFALTVNGDSMVDAYIADGDVVLMEPVSEPSRLRDGTVVSALVPGSGTTLKHFH
RNGASVRLEAANTAYEPIELPADQVQVQGKLVAVWRQV

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=199, Percent_Identity=31.1557788944724, Blast_Score=85, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 21516; Mature: 21516

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSAQQELYDWLADYIGSHHHSPSIRQMMQAMGLRSPAPVQSRLRHLQQKGWITWQEGQ
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEECCC
ARTLQLLGGLVSGIPVLGAVAAGGLVETFDDVQERLDLAPVLETRGLFALTVNGDSMVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHCCCEEEEEECCCCEEEE
YIADGDVVLMEPVSEPSRLRDGTVVSALVPGSGTTLKHFHRNGASVRLEAANTAYEPIEL
EECCCCEEEECCCCCCCHHCCCCEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCC
PADQVQVQGKLVAVWRQV
CHHHHHHHHHHEEEECCC
>Mature Secondary Structure
MLTSAQQELYDWLADYIGSHHHSPSIRQMMQAMGLRSPAPVQSRLRHLQQKGWITWQEGQ
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEECCC
ARTLQLLGGLVSGIPVLGAVAAGGLVETFDDVQERLDLAPVLETRGLFALTVNGDSMVDA
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHCCCEEEEEECCCCEEEE
YIADGDVVLMEPVSEPSRLRDGTVVSALVPGSGTTLKHFHRNGASVRLEAANTAYEPIEL
EECCCCEEEECCCCCCCHHCCCCEEEEEECCCCCHHHHHHCCCCEEEEEECCCCCCCCCC
PADQVQVQGKLVAVWRQV
CHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA