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The map label for this gene is argF [H]

Identifier: 124023615

GI number: 124023615

Start: 1682190

End: 1683146

Strand: Reverse

Name: argF [H]

Synonym: P9303_19151

Alternate gene names: 124023615

Gene position: 1683146-1682190 (Counterclockwise)

Preceding gene: 124023616

Following gene: 124023614

Centisome position: 62.74

GC content: 54.86

Gene sequence:

>957_bases
ATGGCTGTCAATCCCCAAGGTGTTGCAGCCGTCCTTGCTGACCTCAAGGGTCGAGACTTTCTTTCCTGCGCTGATTTCAC
TGCGGAGCAGACGGTTGCCTTGCTTGAGCTTTCCCGTCAGCTGAAGAGCGGGGATCGTCGCATTGATTTGGGAAATCGAG
TTCTCGGATTGATTTTTACGAAGGCATCGACGCGCACACGAGTGAGCTTTCAGGTCGCGATGGCACGCCTTGGCGGGCAA
ACGGTGGATCTCAATCCTCAGGTGACCCAATTGGGCCGCGGCGAACCCCTTGAAGACACGGCGAGAGTGTTGAGTCGTTT
CTGTGATGTGATGGCGGTGCGGACCTTTGCTCAGCAGGAACTGCTGGATTACGCCCATTGGGCTTCGATTCCGGTGCTCA
ATGCTTTGACTGATTTGGAGCATCCCTGTCAGGCAATGGCTGATTTCCTAACCATGCAAGAGGCTCTCGGCTCATTAACC
GGTCAGACCTTGGCCTATGTGGGCGATGGTAATAACGTCTCTCATTCTTTGATGCTCTGCGGCGCTCTCTTGGGGGTCAA
CGTTCGGATTGGCTGCCCGCAAGGATTTGAACCTCTGCCTGAGGTGATTGATCAGGCCCGCAACTTGGCAGTGGCTGATG
CTCGTATTGAAGTAATGACAGACCCAGTTGATGCAGTGCGAGGTGCGCAGGCGTTGTACACCGATGTTTGGGCCTCGATG
GGACAGGAACAGGAACAGTCGCTGCGGGAAGAGGCCTTTCGTGGTTTCTGCCTCAATGAGGATTTGCTTGCTCAGGCAGA
TCCCAACGCGATCGTGTTGCACTGCCTACCGGCTCATCGAGGGGAGGAGATCAGTTCAGCCGTGATGGAAGGTGAGGCCA
GTCGAATCTTCGATCAAGCTGAAAATCGTTTGCATGTTCAACAAGCTTTGCTTGCGGCCGTGCTTGGTGGTCTCTAG

Upstream 100 bases:

>100_bases
GATGCTCGATTCCAGCGCTCTCCCTAGAGGTGTTGTTATTGCCTGAAGGCTTGACGTCAGGGGGGCTGGTCTCCGATAAA
GACTCTTTGAAGCTTCCCTA

Downstream 100 bases:

>100_bases
TTCCAGGCTGGATTGCTGCTTTCGGTTTTGAGCACTCCGGTTAACTCGGTATCGCCTTGCGGCTGCACTGTTTGGTGTTT
AAACCCTTGCCAGATCCAGC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQ
TVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTMQEALGSLT
GQTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
GQEQEQSLREEAFRGFCLNEDLLAQADPNAIVLHCLPAHRGEEISSAVMEGEASRIFDQAENRLHVQQALLAAVLGGL

Sequences:

>Translated_318_residues
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQ
TVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTMQEALGSLT
GQTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
GQEQEQSLREEAFRGFCLNEDLLAQADPNAIVLHCLPAHRGEEISSAVMEGEASRIFDQAENRLHVQQALLAAVLGGL
>Mature_317_residues
AVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFTKASTRTRVSFQVAMARLGGQT
VDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQELLDYAHWASIPVLNALTDLEHPCQAMADFLTMQEALGSLTG
QTLAYVGDGNNVSHSLMLCGALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASMG
QEQEQSLREEAFRGFCLNEDLLAQADPNAIVLHCLPAHRGEEISSAVMEGEASRIFDQAENRLHVQQALLAAVLGGL

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=307, Percent_Identity=40.0651465798046, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI18105007, Length=324, Percent_Identity=31.1728395061728, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786469, Length=333, Percent_Identity=37.5375375375375, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=37.1165644171779, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI2367364, Length=319, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI48994908, Length=363, Percent_Identity=23.1404958677686, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=295, Percent_Identity=29.1525423728814, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322373, Length=308, Percent_Identity=32.7922077922078, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322331, Length=319, Percent_Identity=30.7210031347962, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642586, Length=323, Percent_Identity=30.030959752322, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 34399; Mature: 34267

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFT
CCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEHEEE
KASTRTRVSFQVAMARLGGQTVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQE
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLDYAHWASIPVLNALTDLEHPCQAMADFLTMQEALGSLTGQTLAYVGDGNNVSHSLMLC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
GALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
HHHHCCEEEECCCCCCCHHHHHHHHHHCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHC
GQEQEQSLREEAFRGFCLNEDLLAQADPNAIVLHCLPAHRGEEISSAVMEGEASRIFDQA
CCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHH
ENRLHVQQALLAAVLGGL
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVNPQGVAAVLADLKGRDFLSCADFTAEQTVALLELSRQLKSGDRRIDLGNRVLGLIFT
CCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCEECCCCCEEEHEEE
KASTRTRVSFQVAMARLGGQTVDLNPQVTQLGRGEPLEDTARVLSRFCDVMAVRTFAQQE
CCCCCHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLDYAHWASIPVLNALTDLEHPCQAMADFLTMQEALGSLTGQTLAYVGDGNNVSHSLMLC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
GALLGVNVRIGCPQGFEPLPEVIDQARNLAVADARIEVMTDPVDAVRGAQALYTDVWASM
HHHHCCEEEECCCCCCCHHHHHHHHHHCCEEECCEEEEECCCHHHHHHHHHHHHHHHHHC
GQEQEQSLREEAFRGFCLNEDLLAQADPNAIVLHCLPAHRGEEISSAVMEGEASRIFDQA
CCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCHHHHHHHHH
ENRLHVQQALLAAVLGGL
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]