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The map label for this gene is wprA [H]

Identifier: 124022879

GI number: 124022879

Start: 1030516

End: 1032003

Strand: Reverse

Name: wprA [H]

Synonym: P9303_11721

Alternate gene names: 124022879

Gene position: 1032003-1030516 (Counterclockwise)

Preceding gene: 124022880

Following gene: 124022878

Centisome position: 38.47

GC content: 42.27

Gene sequence:

>1488_bases
ATGCAGCCGTTGACTAAAGATCTAGCATCTGTGCTTACAGGAGCAGTAACAAGTACAACATCAAGCTCATGGCAAAAAAG
AGAACCTTATTACAACTATCAGTGGAGCTTATTTAACAACGGACAATACAATGGCTCCAGGGTTGATGCTGATATTGATG
CCGATGCTGTTTTTTCTAAAACTCCCTATCCTTCATTCTTGATGGATCCAGCGGCAGTTGGTCAAAATACAATCGCTATT
CTTGATACAGGCGTCAACTGGAATCATGTTGATTTAAACGAACGGCTCAATATGAATGCAAACTTTATTTCTAGAGAGCC
TATTGACGGGATTGATAATGATGGCAATGGCTACGTTGATGACCCATTGGGATGGAACTTTATGAACAATGGTAATTCAC
CATTTGATGATCAAGGCCATGGTTCCCACGTGTCTGGATTAGCAGCTGCATCTGCTAATGCCCAAGGAATCGTGGGCACA
AACCCTAATGCATCCATTATCCCGGTTAAAGTCTTAGGGCCTAATGGGGGGACAACCCCAGGGGTTGTTGCTGGAATTAA
TTATGCAGTTAGCAGAGGAGCAAAAATTATCAATATGAGCTTAGGCGGCCCTGGATATTCTCAAGCAATGTATGCGGCAA
TCGCTAATGCTAATAATGCAGGAGCTTTGGTGGTCGCAGCTGCAGGCAATGATTTTGTTAATACCGATTATAATCCCTCT
TATCCAGCAGCATACAACCTACCTAATATAATATCTGTAGCTGCCTCTGATTACACTGACTGGTTTGCCAACTTTTCAAA
CTATGGTAAAGCAACTGTTGACTTATTGGCTCCAGGTAAATTAATGCTAAGTGATTCTCATATTGGCAGTACAGGTCTTG
TTGAAAAAAGTGGAACTTCGATGGCTGCTCCAATCGTAGCTGGCGCAGTCAGTTATTTTTGGTCGCGAAATCCAACCTGG
ACGGCATTACAAGTAAAGGATCGATTACTTAACATCGGCGTTGACAAGATCCCAGGTGCAGAGAATTATACTGTTTCAGG
AGGAAGATTGAACATGGCCCATTTGATGGGCTGGCCTGCAACAGATGTATACACAAGCTCAGGACAAGATGCTGATACTC
TTGCCGGGATGGATCTAAGCACTAATGCAGACCCTGTTATTAACTATGTTCCATTCATTGACAGTAAGAATCTAAGCACA
TTCAACGTTGATGAAGTTACAGATGCTGTGATTGGTATTGTTGATGGAGATGCATTATCAGATCGTATAGCACGTATGAA
AGAATTTCTAACTAGCACAAATATTGGTGAGGTCTATGCTGATCAATTTGATGATTTTGAAATCCTAGATAGCTTAGGCA
CCTCGCTAACAACCATTGATTTCAAAGACCACATCTCAAATGAGGGTAAGCGTAAACTAATGGGTGAGTTCATCGCGCGC
GGGTGGTTTGAAGGCTTTGAAATGAACAGCGAAGTGTCACTGTTCTAG

Upstream 100 bases:

>100_bases
TATAAGAGTTTGGACGTTTAATAAAAACTGGAAATTTAAAAGCAAAAGCGGAAAGATATCCTCTTCGTCAAGAGAGTTTT
CAGCCATGGAGAACGGCTTT

Downstream 100 bases:

>100_bases
AAATTTACTGCCTCCATTTATTTAGCTCAGCAATGGTTTCTAGCTTGGCACTAACAGGAAATCAAAGTTTATTGCCTTTG
CGACTATTGAGTCGATCAAG

Product: hypothetical protein

Products: NA

Alternate protein names: CWBP23; CWBP52 [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MQPLTKDLASVLTGAVTSTTSSSWQKREPYYNYQWSLFNNGQYNGSRVDADIDADAVFSKTPYPSFLMDPAAVGQNTIAI
LDTGVNWNHVDLNERLNMNANFISREPIDGIDNDGNGYVDDPLGWNFMNNGNSPFDDQGHGSHVSGLAAASANAQGIVGT
NPNASIIPVKVLGPNGGTTPGVVAGINYAVSRGAKIINMSLGGPGYSQAMYAAIANANNAGALVVAAAGNDFVNTDYNPS
YPAAYNLPNIISVAASDYTDWFANFSNYGKATVDLLAPGKLMLSDSHIGSTGLVEKSGTSMAAPIVAGAVSYFWSRNPTW
TALQVKDRLLNIGVDKIPGAENYTVSGGRLNMAHLMGWPATDVYTSSGQDADTLAGMDLSTNADPVINYVPFIDSKNLST
FNVDEVTDAVIGIVDGDALSDRIARMKEFLTSTNIGEVYADQFDDFEILDSLGTSLTTIDFKDHISNEGKRKLMGEFIAR
GWFEGFEMNSEVSLF

Sequences:

>Translated_495_residues
MQPLTKDLASVLTGAVTSTTSSSWQKREPYYNYQWSLFNNGQYNGSRVDADIDADAVFSKTPYPSFLMDPAAVGQNTIAI
LDTGVNWNHVDLNERLNMNANFISREPIDGIDNDGNGYVDDPLGWNFMNNGNSPFDDQGHGSHVSGLAAASANAQGIVGT
NPNASIIPVKVLGPNGGTTPGVVAGINYAVSRGAKIINMSLGGPGYSQAMYAAIANANNAGALVVAAAGNDFVNTDYNPS
YPAAYNLPNIISVAASDYTDWFANFSNYGKATVDLLAPGKLMLSDSHIGSTGLVEKSGTSMAAPIVAGAVSYFWSRNPTW
TALQVKDRLLNIGVDKIPGAENYTVSGGRLNMAHLMGWPATDVYTSSGQDADTLAGMDLSTNADPVINYVPFIDSKNLST
FNVDEVTDAVIGIVDGDALSDRIARMKEFLTSTNIGEVYADQFDDFEILDSLGTSLTTIDFKDHISNEGKRKLMGEFIAR
GWFEGFEMNSEVSLF
>Mature_495_residues
MQPLTKDLASVLTGAVTSTTSSSWQKREPYYNYQWSLFNNGQYNGSRVDADIDADAVFSKTPYPSFLMDPAAVGQNTIAI
LDTGVNWNHVDLNERLNMNANFISREPIDGIDNDGNGYVDDPLGWNFMNNGNSPFDDQGHGSHVSGLAAASANAQGIVGT
NPNASIIPVKVLGPNGGTTPGVVAGINYAVSRGAKIINMSLGGPGYSQAMYAAIANANNAGALVVAAAGNDFVNTDYNPS
YPAAYNLPNIISVAASDYTDWFANFSNYGKATVDLLAPGKLMLSDSHIGSTGLVEKSGTSMAAPIVAGAVSYFWSRNPTW
TALQVKDRLLNIGVDKIPGAENYTVSGGRLNMAHLMGWPATDVYTSSGQDADTLAGMDLSTNADPVINYVPFIDSKNLST
FNVDEVTDAVIGIVDGDALSDRIARMKEFLTSTNIGEVYADQFDDFEILDSLGTSLTTIDFKDHISNEGKRKLMGEFIAR
GWFEGFEMNSEVSLF

Specific function: CWBP52 is a serine-type protease that could be involved in proteoglycan peptide bridges [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted, cell wall. Note=Released into the medium [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=273, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=301, Percent_Identity=33.8870431893688, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319893, Length=267, Percent_Identity=30.7116104868914, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324576, Length=269, Percent_Identity=31.9702602230483, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550681, Length=250, Percent_Identity=28.4, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 52865; Mature: 52865

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLTKDLASVLTGAVTSTTSSSWQKREPYYNYQWSLFNNGQYNGSRVDADIDADAVFSK
CCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCEECC
TPYPSFLMDPAAVGQNTIAILDTGVNWNHVDLNERLNMNANFISREPIDGIDNDGNGYVD
CCCCHHHCCHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCEECCCCCCCCCCCCCEEEC
DPLGWNFMNNGNSPFDDQGHGSHVSGLAAASANAQGIVGTNPNASIIPVKVLGPNGGTTP
CCCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCC
GVVAGINYAVSRGAKIINMSLGGPGYSQAMYAAIANANNAGALVVAAAGNDFVNTDYNPS
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
YPAAYNLPNIISVAASDYTDWFANFSNYGKATVDLLAPGKLMLSDSHIGSTGLVEKSGTS
CCCCCCCCCCEEEHHCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEECCCCC
MAAPIVAGAVSYFWSRNPTWTALQVKDRLLNIGVDKIPGAENYTVSGGRLNMAHLMGWPA
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEECCCEEEHHHHCCCCC
TDVYTSSGQDADTLAGMDLSTNADPVINYVPFIDSKNLSTFNVDEVTDAVIGIVDGDALS
CCCCCCCCCCCHHEECCCCCCCCCCEEEEECCCCCCCCCEECHHHHHHHEEEEECCHHHH
DRIARMKEFLTSTNIGEVYADQFDDFEILDSLGTSLTTIDFKDHISNEGKRKLMGEFIAR
HHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCEEEEECHHHHCCCHHHHHHHHHHHH
GWFEGFEMNSEVSLF
HHHHCCCCCCCEECC
>Mature Secondary Structure
MQPLTKDLASVLTGAVTSTTSSSWQKREPYYNYQWSLFNNGQYNGSRVDADIDADAVFSK
CCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCCEECCCCCCCCEECC
TPYPSFLMDPAAVGQNTIAILDTGVNWNHVDLNERLNMNANFISREPIDGIDNDGNGYVD
CCCCHHHCCHHHCCCCEEEEEECCCCCCEECCCCCCCCCCCEECCCCCCCCCCCCCEEEC
DPLGWNFMNNGNSPFDDQGHGSHVSGLAAASANAQGIVGTNPNASIIPVKVLGPNGGTTP
CCCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEEEEEEECCCCCCCC
GVVAGINYAVSRGAKIINMSLGGPGYSQAMYAAIANANNAGALVVAAAGNDFVNTDYNPS
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
YPAAYNLPNIISVAASDYTDWFANFSNYGKATVDLLAPGKLMLSDSHIGSTGLVEKSGTS
CCCCCCCCCCEEEHHCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEECCCCC
MAAPIVAGAVSYFWSRNPTWTALQVKDRLLNIGVDKIPGAENYTVSGGRLNMAHLMGWPA
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEECCCEEEHHHHCCCCC
TDVYTSSGQDADTLAGMDLSTNADPVINYVPFIDSKNLSTFNVDEVTDAVIGIVDGDALS
CCCCCCCCCCCHHEECCCCCCCCCCEEEEECCCCCCCCCEECHHHHHHHEEEEECCHHHH
DRIARMKEFLTSTNIGEVYADQFDDFEILDSLGTSLTTIDFKDHISNEGKRKLMGEFIAR
HHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHCCCCEEEEECHHHHCCCHHHHHHHHHHHH
GWFEGFEMNSEVSLF
HHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9004506; 9353931; 9384377; 10658653 [H]