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The map label for this gene is melB [C]

Identifier: 124022278

GI number: 124022278

Start: 546584

End: 548026

Strand: Reverse

Name: melB [C]

Synonym: P9303_05681

Alternate gene names: 124022278

Gene position: 548026-546584 (Counterclockwise)

Preceding gene: 124022279

Following gene: 124022277

Centisome position: 20.43

GC content: 57.73

Gene sequence:

>1443_bases
ATGCCACTGCATTATGACCTTGCGCATCCCCCTTTTTGCAGCTTGACGACATCCACAGCGCTTCAGGGGGGATCACGCCG
CCGGCTGATGGTCTCCTATGGCCTTGGCGATGCAGGAACCGGACTGGCAGCAACTCTGCTTGGGTTCTACCTGTTCGTGT
TCTTTACCGGGACCGCCGGGCTGCCTGCAATTGTTGCCGGCTCACTGCTGATGGTGATCAAGCTCTGGGATGGGATCAAT
GACCCAATGATCGGCTGGCTGAGCGATCACACCCAAACTCGTTGGGGGCCAAGGGTTCCCTGGATGCTTGGCGGAGCACT
GCCCCTCGGCATCAGCCTGGCCGCAATGTGGTGGGTTCCTCCCGGAGACGTTGCCCAGAAAACGACGTATTACATCGTGA
TGGCGATTCTGCTGATGACCGCCTACACCAGCGTCAATCTGCCTTACTCCGCCCTCTCCACAGAGCTCACAGAAAACACA
TCTGTGCGCAACCGTCTCAACGCCGCCAGATTCACCGGATCAATCATCGCTGGTGCAAGCGGCTTGATCGTGACTCCTTT
ACTGCTGGTCAACGGTGCCAACGGTTACTTGGCCATGGGCCGCATCACCGGCACAATCGCGGCTTTAGCCACCCTCGCCT
GCTGCTGGGGGCTAGCCCCTTTCACAAAAACCGCCCGGCGCCCCAGTTGCCATCACGAGCCCCTAAGTCGACAGCTTGTG
AGGATCATCAGCAACAGACGCTTCCTCAAAGTTCTGGGGCTTTACCTGTTGCTCTGGTGCGCTTTGCAGTTGATGCAGCC
AGTTGCTCTGATCTACCTGGTCCAGTTGATGCGCGTACCCGCAGAACTGGCAACCTGGATGTTGCTGCCCTTCCAGCTCT
GCGCCCTGATCGGCCTTCAGGTCTGGAGCATGTATGCCAATCGCCATGGGCGAATCAGGGCCCTGTGCTGGGGTGGGTGT
CTATGGATCGCTGCTTGTGTTGTTTCGATGCTGCTTCCCCCCCTCTCCGCTGATGCATCCCTCGCCAACCTCTGGCCTAC
AGCAGGCACTGATGGCCTGAGATTGATGGCTTTGTTGGCGACCATTGGCACGGTGGGATTTGGAGCCGCAACTGCTTATC
TGATCCCTTGGTGTCTGCTACCAGATGCAATTGATGCTGACCCTGACAAGCCAGCAGGCCTCTACACCGCCTGGATGGTG
CTGGTTCAGAAAATCGGTATTGGTGTGAGCATCCAACTGCTCGGCATCCTGCTTTCACTGTCTGGCTATCGCTCAGTAGC
AGAAGCTGGCGGAGCACTGAGCTATTCGAATCAACCAGAATCCGCTCTGATCACCATTCGCATGTGCATGGGATTCATTC
CCGCCGTGCTTGTGGCGCTGGGTCTTGTGGTGATGCGAGGCTGGCCCGAAAGGAACTCTCACAACCAGGCAGCCACGTCA
TGA

Upstream 100 bases:

>100_bases
ACCCGCGTCATCAGCTTGGAAGGCTGAGGTCTTACCACTACACAACGCCCGCACTAGTACAACAGAACCATCGCGATAGA
CGAAGTGGGCCTGCGGTTCA

Downstream 100 bases:

>100_bases
CGACTCCTCGCTGGCTGAAGCGACTGGGCAGCAGCCTCATCATCGGAGGCCAGGCAGTGGCCGCCACCGCCAGAGGTCGT
ATCAACAAGGTCGACCTGTT

Product: GPH family sugar transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MPLHYDLAHPPFCSLTTSTALQGGSRRRLMVSYGLGDAGTGLAATLLGFYLFVFFTGTAGLPAIVAGSLLMVIKLWDGIN
DPMIGWLSDHTQTRWGPRVPWMLGGALPLGISLAAMWWVPPGDVAQKTTYYIVMAILLMTAYTSVNLPYSALSTELTENT
SVRNRLNAARFTGSIIAGASGLIVTPLLLVNGANGYLAMGRITGTIAALATLACCWGLAPFTKTARRPSCHHEPLSRQLV
RIISNRRFLKVLGLYLLLWCALQLMQPVALIYLVQLMRVPAELATWMLLPFQLCALIGLQVWSMYANRHGRIRALCWGGC
LWIAACVVSMLLPPLSADASLANLWPTAGTDGLRLMALLATIGTVGFGAATAYLIPWCLLPDAIDADPDKPAGLYTAWMV
LVQKIGIGVSIQLLGILLSLSGYRSVAEAGGALSYSNQPESALITIRMCMGFIPAVLVALGLVVMRGWPERNSHNQAATS

Sequences:

>Translated_480_residues
MPLHYDLAHPPFCSLTTSTALQGGSRRRLMVSYGLGDAGTGLAATLLGFYLFVFFTGTAGLPAIVAGSLLMVIKLWDGIN
DPMIGWLSDHTQTRWGPRVPWMLGGALPLGISLAAMWWVPPGDVAQKTTYYIVMAILLMTAYTSVNLPYSALSTELTENT
SVRNRLNAARFTGSIIAGASGLIVTPLLLVNGANGYLAMGRITGTIAALATLACCWGLAPFTKTARRPSCHHEPLSRQLV
RIISNRRFLKVLGLYLLLWCALQLMQPVALIYLVQLMRVPAELATWMLLPFQLCALIGLQVWSMYANRHGRIRALCWGGC
LWIAACVVSMLLPPLSADASLANLWPTAGTDGLRLMALLATIGTVGFGAATAYLIPWCLLPDAIDADPDKPAGLYTAWMV
LVQKIGIGVSIQLLGILLSLSGYRSVAEAGGALSYSNQPESALITIRMCMGFIPAVLVALGLVVMRGWPERNSHNQAATS
>Mature_479_residues
PLHYDLAHPPFCSLTTSTALQGGSRRRLMVSYGLGDAGTGLAATLLGFYLFVFFTGTAGLPAIVAGSLLMVIKLWDGIND
PMIGWLSDHTQTRWGPRVPWMLGGALPLGISLAAMWWVPPGDVAQKTTYYIVMAILLMTAYTSVNLPYSALSTELTENTS
VRNRLNAARFTGSIIAGASGLIVTPLLLVNGANGYLAMGRITGTIAALATLACCWGLAPFTKTARRPSCHHEPLSRQLVR
IISNRRFLKVLGLYLLLWCALQLMQPVALIYLVQLMRVPAELATWMLLPFQLCALIGLQVWSMYANRHGRIRALCWGGCL
WIAACVVSMLLPPLSADASLANLWPTAGTDGLRLMALLATIGTVGFGAATAYLIPWCLLPDAIDADPDKPAGLYTAWMVL
VQKIGIGVSIQLLGILLSLSGYRSVAEAGGALSYSNQPESALITIRMCMGFIPAVLVALGLVVMRGWPERNSHNQAATS

Specific function: Unknown

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Homo sapiens, GI42713696, Length=487, Percent_Identity=24.435318275154, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI211063479, Length=500, Percent_Identity=24, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786466, Length=450, Percent_Identity=26.2222222222222, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082306, Length=456, Percent_Identity=24.3421052631579, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790561, Length=249, Percent_Identity=25.3012048192771, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994989, Length=474, Percent_Identity=21.9409282700422, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787902, Length=144, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 51572; Mature: 51441

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHYDLAHPPFCSLTTSTALQGGSRRRLMVSYGLGDAGTGLAATLLGFYLFVFFTGTAG
CCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
LPAIVAGSLLMVIKLWDGINDPMIGWLSDHTQTRWGPRVPWMLGGALPLGISLAAMWWVP
CHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHEEECC
PGDVAQKTTYYIVMAILLMTAYTSVNLPYSALSTELTENTSVRNRLNAARFTGSIIAGAS
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GLIVTPLLLVNGANGYLAMGRITGTIAALATLACCWGLAPFTKTARRPSCHHEPLSRQLV
HHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHH
RIISNRRFLKVLGLYLLLWCALQLMQPVALIYLVQLMRVPAELATWMLLPFQLCALIGLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSMYANRHGRIRALCWGGCLWIAACVVSMLLPPLSADASLANLWPTAGTDGLRLMALLA
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHH
TIGTVGFGAATAYLIPWCLLPDAIDADPDKPAGLYTAWMVLVQKIGIGVSIQLLGILLSL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SGYRSVAEAGGALSYSNQPESALITIRMCMGFIPAVLVALGLVVMRGWPERNSHNQAATS
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLHYDLAHPPFCSLTTSTALQGGSRRRLMVSYGLGDAGTGLAATLLGFYLFVFFTGTAG
CCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCC
LPAIVAGSLLMVIKLWDGINDPMIGWLSDHTQTRWGPRVPWMLGGALPLGISLAAMWWVP
CHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHEEECC
PGDVAQKTTYYIVMAILLMTAYTSVNLPYSALSTELTENTSVRNRLNAARFTGSIIAGAS
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GLIVTPLLLVNGANGYLAMGRITGTIAALATLACCWGLAPFTKTARRPSCHHEPLSRQLV
HHHHHHHHHEECCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHH
RIISNRRFLKVLGLYLLLWCALQLMQPVALIYLVQLMRVPAELATWMLLPFQLCALIGLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSMYANRHGRIRALCWGGCLWIAACVVSMLLPPLSADASLANLWPTAGTDGLRLMALLA
HHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHH
TIGTVGFGAATAYLIPWCLLPDAIDADPDKPAGLYTAWMVLVQKIGIGVSIQLLGILLSL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SGYRSVAEAGGALSYSNQPESALITIRMCMGFIPAVLVALGLVVMRGWPERNSHNQAATS
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]