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The map label for this gene is rfbB [H]

Identifier: 123968985

GI number: 123968985

Start: 1237858

End: 1238856

Strand: Direct

Name: rfbB [H]

Synonym: A9601_14531

Alternate gene names: 123968985

Gene position: 1237858-1238856 (Clockwise)

Preceding gene: 123968984

Following gene: 123968986

Centisome position: 74.13

GC content: 29.73

Gene sequence:

>999_bases
GTGAATGAAAAATTTCTAGTTATAGGTAGTAATAGTTTTAGTGGATCACATTTTGTTTCTGATTTAATAGATTTAGATAT
AAAAGTATTAGGAGTAAGTAGATCTTTAGAACCTAAAGACGTTTTCTTACCTTATAAGTGGAATAAAAAATATTTAAATA
ATTTTCAATTTAATAAAATAAATTTAAATGAAGATCTAAATGAACTTCTTAAACTTATCGAAGAATTTGAACCTACTCAT
ATTGTAAATTTTGCTTCTCAAGGTATGGTTGCCGAAAGCTGGGACAATCCTATTGATTGGTATAAAACTAATGTGATTTC
GCAAGTTGCATTGCATGATGAATTACGTAAATTAAAGTTTCTTAAAAAATATGTCCACGTTACAACTCCAGAGGTTTATG
GAGATACAGGAAGTGGATGGATAAAGGAAAACTTTAATTTTTCTCCAAGTACGCCTTATGCAGTTAGTCGGGCTGCATGT
GATTTACATTTAATGAGTTTTTTTAAGGCATATAGCTTTCCAGTTATTTTTACTCGTGCGGCAAATGTATATGGTCCAGG
CCAACAACTTTATAGAATCATTCCAAGAACAATATTAAGTGCTAAATGTCATAAAAAAATGAATCTTCATGGAGGAGGTT
TATCGGAAAGATCTTTTATATTTATTAAAGATGTAACAGAAGCGACACTTAAGTTAGCATTAAATGCTGAGCCTGGAACA
TCATGGCATTTATCAACAAAGAAAAAGATTAGTATTAAAAATTTAGTAGAAAAAATTTTCGATATTGCAGGTAAAAATCC
TAATTCTCTTGTAAATAATACGCAAGATCGTCTTGGCAAAGATCAAAATTATTTACTTGAAAGTTCAAAAATAAGAGATG
CCTTCAATTGGGAGGATAAGGTAGACTTAGATTCAGGATTAAAAATAACCATGGAATGGATTCAAGAAAACCTAGAAGTT
TTGAAAAATATTTCTTGGAATTATTCTCACAAGTCTTGA

Upstream 100 bases:

>100_bases
GCAATAGATTCAATAAAAAGTGGAGATACTGCAGGAAGAATAATTATTGAATTGTCTCATAAAAAATGAGATAATAAATA
AAGCCAAATAAAATGATATT

Downstream 100 bases:

>100_bases
GGAAAAAAAAAAAAGATTTAAAAAATATATGCATAGATTAATGAAAAATTTAAAAAAATCATTTAAAGAAAAATATAATG
AAAAAGAATTACAAAAAATT

Product: dTDP-D-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MNEKFLVIGSNSFSGSHFVSDLIDLDIKVLGVSRSLEPKDVFLPYKWNKKYLNNFQFNKINLNEDLNELLKLIEEFEPTH
IVNFASQGMVAESWDNPIDWYKTNVISQVALHDELRKLKFLKKYVHVTTPEVYGDTGSGWIKENFNFSPSTPYAVSRAAC
DLHLMSFFKAYSFPVIFTRAANVYGPGQQLYRIIPRTILSAKCHKKMNLHGGGLSERSFIFIKDVTEATLKLALNAEPGT
SWHLSTKKKISIKNLVEKIFDIAGKNPNSLVNNTQDRLGKDQNYLLESSKIRDAFNWEDKVDLDSGLKITMEWIQENLEV
LKNISWNYSHKS

Sequences:

>Translated_332_residues
MNEKFLVIGSNSFSGSHFVSDLIDLDIKVLGVSRSLEPKDVFLPYKWNKKYLNNFQFNKINLNEDLNELLKLIEEFEPTH
IVNFASQGMVAESWDNPIDWYKTNVISQVALHDELRKLKFLKKYVHVTTPEVYGDTGSGWIKENFNFSPSTPYAVSRAAC
DLHLMSFFKAYSFPVIFTRAANVYGPGQQLYRIIPRTILSAKCHKKMNLHGGGLSERSFIFIKDVTEATLKLALNAEPGT
SWHLSTKKKISIKNLVEKIFDIAGKNPNSLVNNTQDRLGKDQNYLLESSKIRDAFNWEDKVDLDSGLKITMEWIQENLEV
LKNISWNYSHKS
>Mature_332_residues
MNEKFLVIGSNSFSGSHFVSDLIDLDIKVLGVSRSLEPKDVFLPYKWNKKYLNNFQFNKINLNEDLNELLKLIEEFEPTH
IVNFASQGMVAESWDNPIDWYKTNVISQVALHDELRKLKFLKKYVHVTTPEVYGDTGSGWIKENFNFSPSTPYAVSRAAC
DLHLMSFFKAYSFPVIFTRAANVYGPGQQLYRIIPRTILSAKCHKKMNLHGGGLSERSFIFIKDVTEATLKLALNAEPGT
SWHLSTKKKISIKNLVEKIFDIAGKNPNSLVNNTQDRLGKDQNYLLESSKIRDAFNWEDKVDLDSGLKITMEWIQENLEV
LKNISWNYSHKS

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=29.4642857142857, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=25.4335260115607, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788353, Length=352, Percent_Identity=24.1477272727273, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17568069, Length=327, Percent_Identity=28.1345565749235, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI115532424, Length=255, Percent_Identity=24.3137254901961, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21356223, Length=324, Percent_Identity=22.8395061728395, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38094; Mature: 38094

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKFLVIGSNSFSGSHFVSDLIDLDIKVLGVSRSLEPKDVFLPYKWNKKYLNNFQFNKI
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCCHHHHCCCCCEEE
NLNEDLNELLKLIEEFEPTHIVNFASQGMVAESWDNPIDWYKTNVISQVALHDELRKLKF
ECCHHHHHHHHHHHHCCCCEEEHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKKYVHVTTPEVYGDTGSGWIKENFNFSPSTPYAVSRAACDLHLMSFFKAYSFPVIFTRA
HHHHHHHCCCHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ANVYGPGQQLYRIIPRTILSAKCHKKMNLHGGGLSERSFIFIKDVTEATLKLALNAEPGT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCC
SWHLSTKKKISIKNLVEKIFDIAGKNPNSLVNNTQDRLGKDQNYLLESSKIRDAFNWEDK
CEECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCCC
VDLDSGLKITMEWIQENLEVLKNISWNYSHKS
CCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNEKFLVIGSNSFSGSHFVSDLIDLDIKVLGVSRSLEPKDVFLPYKWNKKYLNNFQFNKI
CCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCCHHHHCCCCCEEE
NLNEDLNELLKLIEEFEPTHIVNFASQGMVAESWDNPIDWYKTNVISQVALHDELRKLKF
ECCHHHHHHHHHHHHCCCCEEEHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LKKYVHVTTPEVYGDTGSGWIKENFNFSPSTPYAVSRAACDLHLMSFFKAYSFPVIFTRA
HHHHHHHCCCHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEC
ANVYGPGQQLYRIIPRTILSAKCHKKMNLHGGGLSERSFIFIKDVTEATLKLALNAEPGT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCC
SWHLSTKKKISIKNLVEKIFDIAGKNPNSLVNNTQDRLGKDQNYLLESSKIRDAFNWEDK
CEECCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCCC
VDLDSGLKITMEWIQENLEVLKNISWNYSHKS
CCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]