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The map label for this gene is adhC [C]

Identifier: 123968984

GI number: 123968984

Start: 1236759

End: 1237826

Strand: Direct

Name: adhC [C]

Synonym: A9601_14521

Alternate gene names: 123968984

Gene position: 1236759-1237826 (Clockwise)

Preceding gene: 123968980

Following gene: 123968985

Centisome position: 74.06

GC content: 32.68

Gene sequence:

>1068_bases
ATGACTTTCTTAGACATAAAAAATGCAAAGGCAGCAATTCTAGTTAAGCAGAATTCCCCTCTAATTGTAGATGATATTCA
ATTTCCTAAACAATTAGATTACGGACAGGTACTTGTGAAAGTTTTAGTAAGTGGGATTTGCGGTTCTCAACTTGGAGAGA
TTTCAGGGGCAAAGGGGGAAGATAAATATATTCCACATTTACTGGGTCATGAAGGCTGCGGAATAGTTAAAGCTATAGGA
CCTGGAGTTAAAACTGTAAAAGTAAATGATAAGGTTGTGATGCATTGGAGACCTGGATCAGGCATCCAATCTGATCCTCC
AAAATATAAATTCCAAGGAAGAGACTTAAATGCTGGTTGGGTAACAACTTTTAATGAATATGGGATAATCAGTGAAAATA
GATGCACTTCAATAAATAAAGATTTAGACCCAGAAATTGGTTCGCTACTTGGGTGTGCAGTTACTACTGGTTTTGGTGTT
GTAGAAAATAATGCAAAATTAAAAATTGGTGAATCAATCGTTATTTATGGGGCTGGAGGAATTGGTTTAAGTGTGATCGA
GGCTGCAAAAGCCGTTTCAGCATGGCCAATAATTGCTGTTGATATTTTTGATAATAGATTGAATCTAGCGAGAGAGATCG
GCGCAACTCATATTATCAATGGAAAGTCAGGAGATGTTGAGAATAAAATTAATTCGATTTTAAAAAATAAACCTCTTAAT
GTATTTATTGATAATACAGGTATCCCATCAATTATTGAACTTGGTTATTCATTAGTAGATAAGTTTGGAATAATTGTTTT
AGTTGGGGTTCCAAAAATTGGAAATAATATAAATATATTTTCTCTACCTTTACACTTTGGTAAAACCATAGTTGGTTCTC
ATGGTGGAGAATCTAATCCTGATTCTGACATCCCAAGGTATATTAATCATTTCATAAAAAATAAAGTTGATCCAAAAAAA
ATAATTACACAAAGATTTGATCTTGAAAATATAAATAAAGCAATAGATTCAATAAAAAGTGGAGATACTGCAGGAAGAAT
AATTATTGAATTGTCTCATAAAAAATGA

Upstream 100 bases:

>100_bases
AAAAAGTAATTTATAAGCATTAATAAAATATAATAAATTAAAATTGAATCTTTCAAAGTTATTATTTTAAAAACTTACCA
TAAATTTTGAATTTTGATAT

Downstream 100 bases:

>100_bases
GATAATAAATAAAGCCAAATAAAATGATATTGTGAATGAAAAATTTCTAGTTATAGGTAGTAATAGTTTTAGTGGATCAC
ATTTTGTTTCTGATTTAATA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTFLDIKNAKAAILVKQNSPLIVDDIQFPKQLDYGQVLVKVLVSGICGSQLGEISGAKGEDKYIPHLLGHEGCGIVKAIG
PGVKTVKVNDKVVMHWRPGSGIQSDPPKYKFQGRDLNAGWVTTFNEYGIISENRCTSINKDLDPEIGSLLGCAVTTGFGV
VENNAKLKIGESIVIYGAGGIGLSVIEAAKAVSAWPIIAVDIFDNRLNLAREIGATHIINGKSGDVENKINSILKNKPLN
VFIDNTGIPSIIELGYSLVDKFGIIVLVGVPKIGNNINIFSLPLHFGKTIVGSHGGESNPDSDIPRYINHFIKNKVDPKK
IITQRFDLENINKAIDSIKSGDTAGRIIIELSHKK

Sequences:

>Translated_355_residues
MTFLDIKNAKAAILVKQNSPLIVDDIQFPKQLDYGQVLVKVLVSGICGSQLGEISGAKGEDKYIPHLLGHEGCGIVKAIG
PGVKTVKVNDKVVMHWRPGSGIQSDPPKYKFQGRDLNAGWVTTFNEYGIISENRCTSINKDLDPEIGSLLGCAVTTGFGV
VENNAKLKIGESIVIYGAGGIGLSVIEAAKAVSAWPIIAVDIFDNRLNLAREIGATHIINGKSGDVENKINSILKNKPLN
VFIDNTGIPSIIELGYSLVDKFGIIVLVGVPKIGNNINIFSLPLHFGKTIVGSHGGESNPDSDIPRYINHFIKNKVDPKK
IITQRFDLENINKAIDSIKSGDTAGRIIIELSHKK
>Mature_354_residues
TFLDIKNAKAAILVKQNSPLIVDDIQFPKQLDYGQVLVKVLVSGICGSQLGEISGAKGEDKYIPHLLGHEGCGIVKAIGP
GVKTVKVNDKVVMHWRPGSGIQSDPPKYKFQGRDLNAGWVTTFNEYGIISENRCTSINKDLDPEIGSLLGCAVTTGFGVV
ENNAKLKIGESIVIYGAGGIGLSVIEAAKAVSAWPIIAVDIFDNRLNLAREIGATHIINGKSGDVENKINSILKNKPLNV
FIDNTGIPSIIELGYSLVDKFGIIVLVGVPKIGNNINIFSLPLHFGKTIVGSHGGESNPDSDIPRYINHFIKNKVDPKKI
ITQRFDLENINKAIDSIKSGDTAGRIIIELSHKK

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=29.0322580645161, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=29.3956043956044, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=28.4931506849315, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=28.4153005464481, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=28.4153005464481, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=28.2191780821918, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=27.4932614555256, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=24.8663101604278, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI71565154, Length=374, Percent_Identity=25.668449197861, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI156627571, Length=321, Percent_Identity=26.1682242990654, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=29.7587131367292, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788407, Length=331, Percent_Identity=26.5861027190332, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=25.3602305475504, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=26.2857142857143, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081918, Length=355, Percent_Identity=26.7605633802817, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=24.4318181818182, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=25.4491017964072, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=323, Percent_Identity=22.2910216718266, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=372, Percent_Identity=26.6129032258064, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=26.2734584450402, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=26.4094955489614, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562876, Length=252, Percent_Identity=32.1428571428571, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=363, Percent_Identity=26.7217630853994, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=26.8361581920904, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=26.3768115942029, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=352, Percent_Identity=26.1363636363636, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=362, Percent_Identity=25.6906077348066, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=25.5494505494505, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=235, Percent_Identity=27.2340425531915, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=364, Percent_Identity=24.1758241758242, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=26.9541778975741, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17137530, Length=328, Percent_Identity=25.9146341463415, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=24.9240121580547, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 38264; Mature: 38133

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLDIKNAKAAILVKQNSPLIVDDIQFPKQLDYGQVLVKVLVSGICGSQLGEISGAKGE
CCEEEECCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCC
DKYIPHLLGHEGCGIVKAIGPGVKTVKVNDKVVMHWRPGSGIQSDPPKYKFQGRDLNAGW
CCCCCHHHCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCCCCCCEEECCCCCCCCE
VTTFNEYGIISENRCTSINKDLDPEIGSLLGCAVTTGFGVVENNAKLKIGESIVIYGAGG
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCEEEEEECCC
IGLSVIEAAKAVSAWPIIAVDIFDNRLNLAREIGATHIINGKSGDVENKINSILKNKPLN
CHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCE
VFIDNTGIPSIIELGYSLVDKFGIIVLVGVPKIGNNINIFSLPLHFGKTIVGSHGGESNP
EEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECHHHCCEEECCCCCCCCC
DSDIPRYINHFIKNKVDPKKIITQRFDLENINKAIDSIKSGDTAGRIIIELSHKK
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
TFLDIKNAKAAILVKQNSPLIVDDIQFPKQLDYGQVLVKVLVSGICGSQLGEISGAKGE
CEEEECCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCC
DKYIPHLLGHEGCGIVKAIGPGVKTVKVNDKVVMHWRPGSGIQSDPPKYKFQGRDLNAGW
CCCCCHHHCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCCCCCCEEECCCCCCCCE
VTTFNEYGIISENRCTSINKDLDPEIGSLLGCAVTTGFGVVENNAKLKIGESIVIYGAGG
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCEEEEEECCC
IGLSVIEAAKAVSAWPIIAVDIFDNRLNLAREIGATHIINGKSGDVENKINSILKNKPLN
CHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCE
VFIDNTGIPSIIELGYSLVDKFGIIVLVGVPKIGNNINIFSLPLHFGKTIVGSHGGESNP
EEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECHHHCCEEECCCCCCCCC
DSDIPRYINHFIKNKVDPKKIITQRFDLENINKAIDSIKSGDTAGRIIIELSHKK
CCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]