Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 123968731

GI number: 123968731

Start: 1015117

End: 1015920

Strand: Direct

Name: uppS [H]

Synonym: A9601_11981

Alternate gene names: 123968731

Gene position: 1015117-1015920 (Clockwise)

Preceding gene: 123968730

Following gene: 123968732

Centisome position: 60.79

GC content: 30.35

Gene sequence:

>804_bases
ATGAGTTTAGGAAAAATAATTGACGCGAAAAATAATAACTTATCCATGAAAATAGATAAGCAAAAAGTTCCAGAACATGT
TGCAATAATAATGGACGGCAATGGTAGATGGGCAACAAAAAAAGGGTTCCCTCGCACATATGGGCATAAAAAAGGCGTTA
GTGTTTTAAAGGAGATTCTCAAAGCATCAAAAAAATTAGGATGTAAAGTACTAACTGTTTACGCTTTTTCAACAGAGAAT
TGGACAAGACCAACAAAAGAAGTTGACTTCCTCATTAATCTTTTTATCGAAGTTTTGAGAAATGAAATTAGAGAGATACA
TGAAGAATCAACAAAAATAAAATTCATTGGAGATATAACCCCTTTCCCAGAAAATCTAAAAAAAATAATATCTAATTCAG
AATCTCTAACTAAAAACAACAATAAATTTTTATTGAATGTTTGTGTTAACTACGGTGGTAGACAAGAAATAGTAAAAGTT
GCAAAAGAATTAGCATTAAAATCTTCTTCTGGCGAAATAAAACCAAGTGAGGTTAATGAAGAATTATTTAATTCAGAGCT
ATTAACTCGAGGAATTAAAGATCCAGAATTACTAATAAGAACCAGTGGAGAAAAAAGGATAAGTAATTTTCTTTTATGGC
AATTAGCTTATTCAGAAATTTATATATCTGACGTAATGTGGCCTGACTTCAATGAGTTTGAATTTCTAAAAGCAATCATT
GATTACCAATCGAGGAATAGACGTTTCGGAGGTATAGAATCATTACCAAATGAATCTTTTGAAGATTCTCATTATACTCT
CTAA

Upstream 100 bases:

>100_bases
TTTATCCCAAAATACAAAATCAAGTGATAATATTATCAATGATTCTAATGAGAAAGAGAAGGAAAAGCCAGCAATTTTTT
TTAACAAAAATGATTAAATT

Downstream 100 bases:

>100_bases
AAATTATGATAAATTCGAATAATCAGGTCTTAAGTGAAATTAGGTTCGATTGGAATAAAAAGGAGATATTAGAAATTCTT
AATATGCCTCTGATCGATTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSLGKIIDAKNNNLSMKIDKQKVPEHVAIIMDGNGRWATKKGFPRTYGHKKGVSVLKEILKASKKLGCKVLTVYAFSTEN
WTRPTKEVDFLINLFIEVLRNEIREIHEESTKIKFIGDITPFPENLKKIISNSESLTKNNNKFLLNVCVNYGGRQEIVKV
AKELALKSSSGEIKPSEVNEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVMWPDFNEFEFLKAII
DYQSRNRRFGGIESLPNESFEDSHYTL

Sequences:

>Translated_267_residues
MSLGKIIDAKNNNLSMKIDKQKVPEHVAIIMDGNGRWATKKGFPRTYGHKKGVSVLKEILKASKKLGCKVLTVYAFSTEN
WTRPTKEVDFLINLFIEVLRNEIREIHEESTKIKFIGDITPFPENLKKIISNSESLTKNNNKFLLNVCVNYGGRQEIVKV
AKELALKSSSGEIKPSEVNEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVMWPDFNEFEFLKAII
DYQSRNRRFGGIESLPNESFEDSHYTL
>Mature_266_residues
SLGKIIDAKNNNLSMKIDKQKVPEHVAIIMDGNGRWATKKGFPRTYGHKKGVSVLKEILKASKKLGCKVLTVYAFSTENW
TRPTKEVDFLINLFIEVLRNEIREIHEESTKIKFIGDITPFPENLKKIISNSESLTKNNNKFLLNVCVNYGGRQEIVKVA
KELALKSSSGEIKPSEVNEELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVMWPDFNEFEFLKAIID
YQSRNRRFGGIESLPNESFEDSHYTL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=38.3928571428571, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=38.3928571428571, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=45.1754385964912, Blast_Score=233, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.7256637168142, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=241, Percent_Identity=34.8547717842324, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=33.4801762114537, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30669; Mature: 30537

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGKIIDAKNNNLSMKIDKQKVPEHVAIIMDGNGRWATKKGFPRTYGHKKGVSVLKEIL
CCCCCEEECCCCCEEEEECHHHCCCEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
KASKKLGCKVLTVYAFSTENWTRPTKEVDFLINLFIEVLRNEIREIHEESTKIKFIGDIT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPENLKKIISNSESLTKNNNKFLLNVCVNYGGRQEIVKVAKELALKSSSGEIKPSEVNE
CCHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVMWPDFNEFEFLKAII
HHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFEDSHYTL
HHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLGKIIDAKNNNLSMKIDKQKVPEHVAIIMDGNGRWATKKGFPRTYGHKKGVSVLKEIL
CCCCEEECCCCCEEEEECHHHCCCEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
KASKKLGCKVLTVYAFSTENWTRPTKEVDFLINLFIEVLRNEIREIHEESTKIKFIGDIT
HHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PFPENLKKIISNSESLTKNNNKFLLNVCVNYGGRQEIVKVAKELALKSSSGEIKPSEVNE
CCHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
ELFNSELLTRGIKDPELLIRTSGEKRISNFLLWQLAYSEIYISDVMWPDFNEFEFLKAII
HHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DYQSRNRRFGGIESLPNESFEDSHYTL
HHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]