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The map label for this gene is iscS [H]

Identifier: 123968507

GI number: 123968507

Start: 842895

End: 844067

Strand: Direct

Name: iscS [H]

Synonym: A9601_09741

Alternate gene names: 123968507

Gene position: 842895-844067 (Clockwise)

Preceding gene: 123968506

Following gene: 123968508

Centisome position: 50.48

GC content: 26.68

Gene sequence:

>1173_bases
ATGGAAAATAATTTTATCTATTTAGATAATGCATCCACAACTCCATTATCTGAGAATGTTTTAAAGATAATTAATTCAAC
TTATAGGAATTATTGGCATAACCCTTCATCTACATATGAGCTAGGTATAAAATGCTCTACTTATCTTGAAAAAATTAGAT
CCAAAATAGCTTATATATTTGAAGCAGATCCAGAGGATATAATTTTTACATCTGGTTCTTCGGAATCGACAAATATTGTA
TTTAATAATATTTATGAGAAATTTAAAAATGGTAGGGTTGTTATTTCAAATGTCGAACATCAAGCAACAATTATTTGTGC
TAATAAACTAAGAAAACAAAATTGGGATATTTTCGAATGGACGGTAAAAAATGATGGAATTTTAAATATTTCCAATATCG
AAAAATTTTTAAACAATGATACTAAGCTTGTATCAATTATTTGGGGACAAAGTGAAATTGGGACAATACAACCTGTCCAA
TTTATTGGTTCCAAATGTGAAGAATTAAATATAATGTTTCATTTAGATGGAACTCAAATATTAAGTAATGGAATATTCAG
TTGGAAAGATCTTAAATGTGATTTTTTAAGTTTATCCGCTCATAAATTTGGAGGTCCAAAAGGGATCGGTATTCTTTTAA
CAAAAGAAAAGTCTAGACAAATTTTAAAAAATAATGACATATCACTTACTCAGGAATTTTCAATTAGACAAGGTACACAA
GCTTTGCCATTAATCGCTGGAATGTATGAATCACTAAAGAATATTGAAGGAAAAATTAAATTATATGATTACATAACTGA
ATTTCCTTCTAATAATATTAATAAACTTAAAAATTATTTTTTTCAAAAAATTAAAGATAATAATCATATAAAGATTACGG
GTAGTATTAACCATAGACTTCCCAGTCATATTTCTTTTCTACTGTTAAATAAACTATTTGAGCCTATACGGGCCTATAAG
ATTGTTAATTTCATGTCAGAAAATAAAATAGCCATAAGCAGTGGAAGTGCTTGTTCAAGCTCATCTGGGAAACCTAGCTC
AACACTTAAAAATATTGGTTTAAAAGATGATGAACTATATTCAAATATTCGTGTTACTTTAGGTTCAATAAACAATAAGT
CAGAAATAGATAAATTTTTAGAACTTATTCAAATATGTATTGACAAATTTTAA

Upstream 100 bases:

>100_bases
CAGGAGGTAATCTTAAAATTGATTGGTCAGAAGACGATTGTGAAGTAATGATGACCGGTAATGCTAAAAAGGTTTTCTCA
GGATCAATTTTAGTAAATTA

Downstream 100 bases:

>100_bases
TGGAAACTAATTACAGACTACCTAAAGATTTAAATGAATCTCTTAAGAATATGGAGGATGCAATTATTCCAAGTTTATTA
GATTCAAATAAAAGATTTAC

Product: class-V aminotransferase family cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MENNFIYLDNASTTPLSENVLKIINSTYRNYWHNPSSTYELGIKCSTYLEKIRSKIAYIFEADPEDIIFTSGSSESTNIV
FNNIYEKFKNGRVVISNVEHQATIICANKLRKQNWDIFEWTVKNDGILNISNIEKFLNNDTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKLFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF

Sequences:

>Translated_390_residues
MENNFIYLDNASTTPLSENVLKIINSTYRNYWHNPSSTYELGIKCSTYLEKIRSKIAYIFEADPEDIIFTSGSSESTNIV
FNNIYEKFKNGRVVISNVEHQATIICANKLRKQNWDIFEWTVKNDGILNISNIEKFLNNDTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKLFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF
>Mature_390_residues
MENNFIYLDNASTTPLSENVLKIINSTYRNYWHNPSSTYELGIKCSTYLEKIRSKIAYIFEADPEDIIFTSGSSESTNIV
FNNIYEKFKNGRVVISNVEHQATIICANKLRKQNWDIFEWTVKNDGILNISNIEKFLNNDTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKLFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=29.7368421052632, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI156713448, Length=430, Percent_Identity=25.5813953488372, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=31.2020460358056, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=23.3502538071066, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=29.7157622739018, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17533177, Length=347, Percent_Identity=25.9365994236311, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=385, Percent_Identity=31.9480519480519, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI20129463, Length=385, Percent_Identity=29.8701298701299, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44377; Mature: 44377

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNFIYLDNASTTPLSENVLKIINSTYRNYWHNPSSTYELGIKCSTYLEKIRSKIAYIF
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHEEEEE
EADPEDIIFTSGSSESTNIVFNNIYEKFKNGRVVISNVEHQATIICANKLRKQNWDIFEW
ECCCCCEEEECCCCCCCEEEHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHCCCCCEEEE
TVKNDGILNISNIEKFLNNDTKLVSIIWGQSEIGTIQPVQFIGSKCEELNIMFHLDGTQI
EECCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCHHH
LSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
HHCCCCCCCCCCEEEEEECHHHCCCCCCEEEEEECHHHHHHHCCCCCCEEEECCCCCCCC
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
PSHISFLLLNKLFEPIRAYKIVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHH
SNIRVTLGSINNKSEIDKFLELIQICIDKF
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENNFIYLDNASTTPLSENVLKIINSTYRNYWHNPSSTYELGIKCSTYLEKIRSKIAYIF
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHEEEEE
EADPEDIIFTSGSSESTNIVFNNIYEKFKNGRVVISNVEHQATIICANKLRKQNWDIFEW
ECCCCCEEEECCCCCCCEEEHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHCCCCCEEEE
TVKNDGILNISNIEKFLNNDTKLVSIIWGQSEIGTIQPVQFIGSKCEELNIMFHLDGTQI
EECCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCHHH
LSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
HHCCCCCCCCCCEEEEEECHHHCCCCCCEEEEEECHHHHHHHCCCCCCEEEECCCCCCCC
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
PSHISFLLLNKLFEPIRAYKIVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHH
SNIRVTLGSINNKSEIDKFLELIQICIDKF
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA