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The map label for this gene is tmk [H]

Identifier: 123967684

GI number: 123967684

Start: 136868

End: 137506

Strand: Reverse

Name: tmk [H]

Synonym: A9601_01471

Alternate gene names: 123967684

Gene position: 137506-136868 (Counterclockwise)

Preceding gene: 123967685

Following gene: 123967683

Centisome position: 8.23

GC content: 30.83

Gene sequence:

>639_bases
ATGAAAGGAAAATTTATCGTTATTGAGGGTATTGATGGATGTGGTAAAACCACCCAAATAGATGAACTATCTAAGTGGCT
ACCCAACAGTGGTTTAATAAAGAAAGGGTCTAAATTAATCACAACTAGAGAGCCAGGAGGCAGTCTTTTAGGAAAAAAAC
TTAGAGGACTGATTCTTGATAATAATAAAAATAACAAGCCTTCATCTCTTGCGGAATTATTACTTTATTCAGCGGATAGA
GCTGAACACGTTTCCAAAATTATTTCACCTGCTTTAAATAATAATGATTGGGTAATAAGTGATAGATTTTCTGATTCCAC
ACTGGCTTATCAAGGTTATGGAAGAAATATAAATTTAGAAATAATTAAAAATATTGAATCTATTGTGTGTCAAGGAGCAT
CCCCTGATCTCACTTTCTTCTTAGAAATTTCTCCAGAAGAGAGCATATTCCGAAGAAAAAATGAAATTCCAGACAGAATA
GAATCAGAAGGTATTAGATTTTTAGAAAAAGTAAATGAAGGATTCAAACTAATTGCCAAACAAAAAAACTGGAAAGTAAT
ATCAGCTTCACAAAATATTCAAACTATTTCTAATCAAATTAAAGAGACTTTGCTAAACAATTTTTCTAATAACAAATGA

Upstream 100 bases:

>100_bases
ATTCCCTAAATACGGTATTCTTCTTACTCCCTCAATAGCAGCATTATTGATGGCTATTAGTTCTATTACAGTTGTAATCA
ATGCTTTATCTTTGGATTGA

Downstream 100 bases:

>100_bases
TTAAGGTTAAAAAAGATAATTTTTTCTTGAATGAAGAAGTCAATACCTGTCTTAACAACATAATTAAAAATAAATCATTT
GCTAATGGTTATATATTTTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPNSGLIKKGSKLITTREPGGSLLGKKLRGLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLEKVNEGFKLIAKQKNWKVISASQNIQTISNQIKETLLNNFSNNK

Sequences:

>Translated_212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPNSGLIKKGSKLITTREPGGSLLGKKLRGLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLEKVNEGFKLIAKQKNWKVISASQNIQTISNQIKETLLNNFSNNK
>Mature_212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPNSGLIKKGSKLITTREPGGSLLGKKLRGLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLEKVNEGFKLIAKQKNWKVISASQNIQTISNQIKETLLNNFSNNK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=211, Percent_Identity=36.0189573459716, Blast_Score=134, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23751; Mature: 23751

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFIVIEGIDGCGKTTQIDELSKWLPNSGLIKKGSKLITTREPGGSLLGKKLRGLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEE
NNKNNKPSSLAELLLYSADRAEHVSKIISPALNNNDWVISDRFSDSTLAYQGYGRNINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCHH
IIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRIESEGIRFLEKVNEGFKLIAK
HHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEC
QKNWKVISASQNIQTISNQIKETLLNNFSNNK
CCCCEEEECCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGKFIVIEGIDGCGKTTQIDELSKWLPNSGLIKKGSKLITTREPGGSLLGKKLRGLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEE
NNKNNKPSSLAELLLYSADRAEHVSKIISPALNNNDWVISDRFSDSTLAYQGYGRNINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCHH
IIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRIESEGIRFLEKVNEGFKLIAK
HHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEC
QKNWKVISASQNIQTISNQIKETLLNNFSNNK
CCCCEEEECCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA