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The map label for this gene is purL [H]

Identifier: 123967539

GI number: 123967539

Start: 2038

End: 4377

Strand: Direct

Name: purL [H]

Synonym: A9601_00021

Alternate gene names: 123967539

Gene position: 2038-4377 (Clockwise)

Preceding gene: 123967538

Following gene: 123967540

Centisome position: 0.12

GC content: 32.44

Gene sequence:

>2340_bases
ATGATAAATCATGAAAATAATGATCTATTTGATCTTAATGAAGCATTAAAAGTTGAAAATTTAACACTTAATGATTACGA
AGAAATTTGCAAAAGATTAAAGAGAAAACCTAATAGAACGGAATTAGGCATGTTTGGCGTTATGTGGTCTGAACATTGTT
GTTATAGAAATTCAAAACCTTTACTATCTAAGTTTCCTACTAAAGGTAAAAATGTTTTAGTTGGACCTGGAGAAAATGCT
GGCGTTATTGATGTTGGAAATAATCAAAAACTTGTTTTTAAAATAGAAAGTCATAATCATCCATCTGCTATTGAACCTTT
TCAAGGCGCAGCAACAGGTGTAGGAGGAATTTTAAGAGATATATTTACAATGGGTGCAAGGCCAATAGCAGTGTTGAATT
CATTGAGATTTGGTAACCTTGATAAATCATCAAATGTTGATTTACTACGAGGAGTTGTATCGGGTATTGCACATTATGGA
AATTGTGTAGGGGTGCCTACTGTTGGAGGTGAAATTGACTTCGATGATAGTTACTCTGGAAATCCTCTAGTGAATGTCAT
GGCTTTAGGACTTTTAGAGACCGAGGAAATCGTTTGTTCTGGAGCTAAAAATGTAGGATCACCAGTATTATATGTTGGTA
ATACAACTGGCAGAGACGGTGTTGGAGGTGCTAGTTTTGCTAGTTCAGAATTAACTACAACTTCATTGGATGATCGACCT
GCAGTTCAGGTAGGTGATCCATTTATTGAGAAAAGTCTTATTGAAGCTTGTTTGGATGCTTTCAAGACAGGGGATGTAAT
TGCAGCTCAAGATATGGGTGCTGCAGGTTTAACATGCAGTAGCGCAGAAATGGCCGCAAATGGAAATTTAGGGATATCTA
TTGATTTAGATTTGGTCCCTTCTAGAGAAGATGATATGTCTTCATATCAATATTTATTATCTGAATCGCAAGAAAGAATG
TTGTTTGTGGTTAAGGAAGAAAAAATTAGTGATCTTATTGAAAAATTTAATAAATGGGGATTATATGCCAGTGTTATTGG
TGAAGTTATAGGAACTAATGAGGTAATTATTTCTCATAAAGGTAATATTGTGGCCCAAATACCTACTTCTGCCTTATCTG
ATGATACTCCTGTAAATTTTCACAATGTGATTAATAATCCACCCGACGATCTTTTAAATAAATGGGAATGGAAAGAAAAT
GATTTACCAGAAATTAACGAGCAAAAAATATTTTCATTGAAGGAAAATAAAAAATTTTCTTTTTCAGAAATCATTTTAAA
GCTACTCTCTAATCCATCAATAGCTTCTAAAAGATGGATTTATAAACAATATGACTCTCAAGTACAAGCAAATACAGTAT
TTACACCTGGAAAATCAGATGCAGCTGTAGTAAGACTAAGGGAACAAAATAAAAAAAGTAAAAATAAAGTATTTTCTGGT
GTTGCTGCTTCAGTTGATTGTAATAGTAGATGGGTTGCGCTTGATCCTTTTAGAGGATCTATCGCTGCTGTAGCAGAATC
AGCTAGAAATGTTAGTTGTGTTGGTGCTGAACCAGTAGCAATTACAAATAATTTAAATTTTTCTTCTCCTGAGAATGAAA
TAGGATATTGGCAACTCTCATCTTCATGTAATGGAATTGCTGAAGCCTGTAAAGCTTTAGAAACTCCTGTTACAGGAGGT
AATGTATCTTTATATAATGAATCAAAAAATAAAGATAATCTAATTACTCCTATTAATCCTACTCCTGTTATTGGAATGGT
TGGAAAGATAGATAATGTCGAAAAAGCTATAAGTAGTGAATGGAAAAATATTGAAGATCAAATCTGGTTAATTGGTTCTT
ATAAATCAGATACGACAACTGCAGCTAGTTCTTATTTGGAATATTTTCATGGAGAAATTACAGGTCGGCCTCCAAAAATA
GATTTGTCGGATGAAAAGTTTTGTCAGAGTTTTTTAAGAAATGCGATTTTAAACAGTCTTGTAGTTTCTTCTCACGATAT
AAGTGACGGAGGTTTAGCTATAGCTTTAGCAGAGTCTTGTATTTTGTCCGCAAGGGGTGCAACTATAGAATTAGAGAAAG
ATTTAAATAGAGTTGATAATTTATTATTTGCCGAAGGGGGGTCAAGAATTATTTTTTCAATTAGTAAAATGAAACAAAAT
GAATGGTTTAATTATTTAAAACAAAATCAAATAAATTTTCCATCAAGTGTTTATGTAAAAAAAATAGGATACGTATCTAG
TGATACGCTGAAGATAAAAATCAACGAAAAAAATATTTGCAATATTAGGGTTGAGGAATTAACCGAAAAATTTAATAATA
GTATTTCAGATTACTTTTAA

Upstream 100 bases:

>100_bases
AAGCGAAAATTTAGATTTTAAACAAAAAAGTTTTTATAATAACGACAGAACCTCTAGAGAGTTTAGTGAAAAAAAAGAAG
ATGACCCTTGGATATAAATA

Downstream 100 bases:

>100_bases
ATATGAAAAATATTTCTCAACTATTTATCATTTTAAAATATTAAGTTATGTGCGGAATAGTTGGAATCGTTTCTTCGAAT
GATGTAAATCAACAAATTTA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MINHENNDLFDLNEALKVENLTLNDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSKFPTKGKNVLVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKSSNVDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETEEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTTTSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDDMSSYQYLLSESQERM
LFVVKEEKISDLIEKFNKWGLYASVIGEVIGTNEVIISHKGNIVAQIPTSALSDDTPVNFHNVINNPPDDLLNKWEWKEN
DLPEINEQKIFSLKENKKFSFSEIILKLLSNPSIASKRWIYKQYDSQVQANTVFTPGKSDAAVVRLREQNKKSKNKVFSG
VAASVDCNSRWVALDPFRGSIAAVAESARNVSCVGAEPVAITNNLNFSSPENEIGYWQLSSSCNGIAEACKALETPVTGG
NVSLYNESKNKDNLITPINPTPVIGMVGKIDNVEKAISSEWKNIEDQIWLIGSYKSDTTTAASSYLEYFHGEITGRPPKI
DLSDEKFCQSFLRNAILNSLVVSSHDISDGGLAIALAESCILSARGATIELEKDLNRVDNLLFAEGGSRIIFSISKMKQN
EWFNYLKQNQINFPSSVYVKKIGYVSSDTLKIKINEKNICNIRVEELTEKFNNSISDYF

Sequences:

>Translated_779_residues
MINHENNDLFDLNEALKVENLTLNDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSKFPTKGKNVLVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKSSNVDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETEEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTTTSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDDMSSYQYLLSESQERM
LFVVKEEKISDLIEKFNKWGLYASVIGEVIGTNEVIISHKGNIVAQIPTSALSDDTPVNFHNVINNPPDDLLNKWEWKEN
DLPEINEQKIFSLKENKKFSFSEIILKLLSNPSIASKRWIYKQYDSQVQANTVFTPGKSDAAVVRLREQNKKSKNKVFSG
VAASVDCNSRWVALDPFRGSIAAVAESARNVSCVGAEPVAITNNLNFSSPENEIGYWQLSSSCNGIAEACKALETPVTGG
NVSLYNESKNKDNLITPINPTPVIGMVGKIDNVEKAISSEWKNIEDQIWLIGSYKSDTTTAASSYLEYFHGEITGRPPKI
DLSDEKFCQSFLRNAILNSLVVSSHDISDGGLAIALAESCILSARGATIELEKDLNRVDNLLFAEGGSRIIFSISKMKQN
EWFNYLKQNQINFPSSVYVKKIGYVSSDTLKIKINEKNICNIRVEELTEKFNNSISDYF
>Mature_779_residues
MINHENNDLFDLNEALKVENLTLNDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKPLLSKFPTKGKNVLVGPGENA
GVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRDIFTMGARPIAVLNSLRFGNLDKSSNVDLLRGVVSGIAHYG
NCVGVPTVGGEIDFDDSYSGNPLVNVMALGLLETEEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTTTSLDDRP
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVPSREDDMSSYQYLLSESQERM
LFVVKEEKISDLIEKFNKWGLYASVIGEVIGTNEVIISHKGNIVAQIPTSALSDDTPVNFHNVINNPPDDLLNKWEWKEN
DLPEINEQKIFSLKENKKFSFSEIILKLLSNPSIASKRWIYKQYDSQVQANTVFTPGKSDAAVVRLREQNKKSKNKVFSG
VAASVDCNSRWVALDPFRGSIAAVAESARNVSCVGAEPVAITNNLNFSSPENEIGYWQLSSSCNGIAEACKALETPVTGG
NVSLYNESKNKDNLITPINPTPVIGMVGKIDNVEKAISSEWKNIEDQIWLIGSYKSDTTTAASSYLEYFHGEITGRPPKI
DLSDEKFCQSFLRNAILNSLVVSSHDISDGGLAIALAESCILSARGATIELEKDLNRVDNLLFAEGGSRIIFSISKMKQN
EWFNYLKQNQINFPSSVYVKKIGYVSSDTLKIKINEKNICNIRVEELTEKFNNSISDYF

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=742, Percent_Identity=22.6415094339623, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17553022, Length=710, Percent_Identity=22.6760563380282, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321498, Length=810, Percent_Identity=23.0864197530864, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 85255; Mature: 85255

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINHENNDLFDLNEALKVENLTLNDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKP
CCCCCCCCEECCCHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCC
LLSKFPTKGKNVLVGPGENAGVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRD
HHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IFTMGARPIAVLNSLRFGNLDKSSNVDLLRGVVSGIAHYGNCVGVPTVGGEIDFDDSYSG
HHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCC
NPLVNVMALGLLETEEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTTTSLDDRP
CHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCCCC
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVP
CEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCHHCCCCCEEEEEEEEECC
SREDDMSSYQYLLSESQERMLFVVKEEKISDLIEKFNKWGLYASVIGEVIGTNEVIISHK
CCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEC
GNIVAQIPTSALSDDTPVNFHNVINNPPDDLLNKWEWKENDLPEINEQKIFSLKENKKFS
CCEEEECCCHHCCCCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCCC
FSEIILKLLSNPSIASKRWIYKQYDSQVQANTVFTPGKSDAAVVRLREQNKKSKNKVFSG
HHHHHHHHHCCCCCHHHHHHHHHHCCCEECCEEECCCCCCCEEEEEHHHCCHHHHHHHHC
VAASVDCNSRWVALDPFRGSIAAVAESARNVSCVGAEPVAITNNLNFSSPENEIGYWQLS
CEEEECCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCCCEEEEC
SSCNGIAEACKALETPVTGGNVSLYNESKNKDNLITPINPTPVIGMVGKIDNVEKAISSE
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEECCCCCCCCEEECCCCHHHHHHHHHH
WKNIEDQIWLIGSYKSDTTTAASSYLEYFHGEITGRPPKIDLSDEKFCQSFLRNAILNSL
HCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VVSSHDISDGGLAIALAESCILSARGATIELEKDLNRVDNLLFAEGGSRIIFSISKMKQN
HHCCCCCCCCCEEEEEHHHHHHCCCCCEEEEHHHHHHHHHEEEECCCCEEEEEEHHHHHH
EWFNYLKQNQINFPSSVYVKKIGYVSSDTLKIKINEKNICNIRVEELTEKFNNSISDYF
HHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MINHENNDLFDLNEALKVENLTLNDYEEICKRLKRKPNRTELGMFGVMWSEHCCYRNSKP
CCCCCCCCEECCCHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCC
LLSKFPTKGKNVLVGPGENAGVIDVGNNQKLVFKIESHNHPSAIEPFQGAATGVGGILRD
HHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
IFTMGARPIAVLNSLRFGNLDKSSNVDLLRGVVSGIAHYGNCVGVPTVGGEIDFDDSYSG
HHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCC
NPLVNVMALGLLETEEIVCSGAKNVGSPVLYVGNTTGRDGVGGASFASSELTTTSLDDRP
CHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEECCCCCCC
AVQVGDPFIEKSLIEACLDAFKTGDVIAAQDMGAAGLTCSSAEMAANGNLGISIDLDLVP
CEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCHHCCCCCEEEEEEEEECC
SREDDMSSYQYLLSESQERMLFVVKEEKISDLIEKFNKWGLYASVIGEVIGTNEVIISHK
CCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEC
GNIVAQIPTSALSDDTPVNFHNVINNPPDDLLNKWEWKENDLPEINEQKIFSLKENKKFS
CCEEEECCCHHCCCCCCCCHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHEEEECCCCCCC
FSEIILKLLSNPSIASKRWIYKQYDSQVQANTVFTPGKSDAAVVRLREQNKKSKNKVFSG
HHHHHHHHHCCCCCHHHHHHHHHHCCCEECCEEECCCCCCCEEEEEHHHCCHHHHHHHHC
VAASVDCNSRWVALDPFRGSIAAVAESARNVSCVGAEPVAITNNLNFSSPENEIGYWQLS
CEEEECCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCCCEEEEC
SSCNGIAEACKALETPVTGGNVSLYNESKNKDNLITPINPTPVIGMVGKIDNVEKAISSE
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEECCCCCCCCEEECCCCHHHHHHHHHH
WKNIEDQIWLIGSYKSDTTTAASSYLEYFHGEITGRPPKIDLSDEKFCQSFLRNAILNSL
HCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VVSSHDISDGGLAIALAESCILSARGATIELEKDLNRVDNLLFAEGGSRIIFSISKMKQN
HHCCCCCCCCCEEEEEHHHHHHCCCCCEEEEHHHHHHHHHEEEECCCCEEEEEEHHHHHH
EWFNYLKQNQINFPSSVYVKKIGYVSSDTLKIKINEKNICNIRVEELTEKFNNSISDYF
HHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA