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The map label for this gene is tktA [H]

Identifier: 123967031

GI number: 123967031

Start: 1583914

End: 1585920

Strand: Direct

Name: tktA [H]

Synonym: P9515_17981

Alternate gene names: 123967031

Gene position: 1583914-1585920 (Clockwise)

Preceding gene: 123967030

Following gene: 123967038

Centisome position: 92.94

GC content: 37.77

Gene sequence:

>2007_bases
ATGGTCGCTGCATCTGTTTCATTAGAATCTTTATGTGTCAATAGTATAAGAATGTTAGCTGTAGATGCAGTAAATAAATC
TAATAGTGGGCATCCCGGTTTACCGATGGGTTGCGCTCCTATGGGTTATGCATTATGGCAAAATATTCTTAATCACAATC
CCAATAATCCAAAGTGGTTCAATAGAGATCGGTTTGTATTATCTGCGGGACATGGATGTATGTTGCTTTATTCCCTATTG
CATCTAACTGGGTATAAATCAGTTTCCATTGAAGATATCAAGGAATTTAGACAATGGGGGTCTAAAACACCCGGGCATCC
AGAAACATTTGAGACTGAGGGGGTTGAAGTAACAGCAGGACCATTAGGTGCGGGGATTTCTAATGCAGTTGGTTTAGCAA
TTGCTGAAACCCACTTAGCCGCAAAATTTAACAAGCCAGACTGTGAAATTGTTGATCATTACACTTACGTCATAATGGGC
GACGGATGTAATCAGGAGGGTATTGCATCAGAAGCATGTTCACTTGCTGGACATCTTAAGCTTGGCAAATTAATTGCTTT
GTATGATGATAATCAAATCACAATTGATGGACGTACAGATGTTTCATTTACAGAAGATGTTTTAAAAAGATATGAAGCGT
ATGGATGGCATGTTCAACATGTTGAAGATGGCAATCATGATGTACAAGGAATTACCAAAGCGATTGAAAGTGCTAAATCT
GTAAAAGATAAACCTTCTCTAATCAAAATTTCTACAACGATAGGTTATGGGTCTCCAAATAAATCTGATACTGCAGGTAT
TCATGGCGCTGCTGTAGGCGAAGAAGAAGCTTCTTTGACTAGAGAGTTTTTAAATTGGGAATACCCTCCTTTTGAAATCC
CTGATGAAGTTTATACCCAATTCAGACAAGCTATTACAAAAGGTGAAGAATCTGAGAAAGAATGGAATTTAAAATTCAAG
GGTTATCAAAATTCATATCCTTCTGAAGGTAATGAATTAAAAAGAATGATACAAGGTGATTTACCAGAGAATTGGGACTC
AGACCTGCCTTCATATACTCCGGACGATAAGGGTTTAGCAACAAGAAAACATTCTCAAATATGCTTGGGAGCTCTTGGCC
CTAATCTACCTGAATTAATTGGAGGGTCTGCTGATTTAACACACTCAAATTACACAGACATAAAAGGAGAAACAGGCTCA
TTTCAGGCACATTCTCCAGAAAAGAGATATTTACATTTTGGTGTAAGAGAGCATGCCATGGCAGCAATATTAAATGGAAT
TGCTTATCACGACAGTGGACTAATACCTTATGGAGGTACTTTTCTCGTTTTTGCAGATTACATGAGAGGTTCAATGAGAC
TTTCTGCTCTCAGTGAACTTGGTGTTATTTATGTACTTACTCATGATTCAATTGGAGTAGGCGAAGATGGTCCAACACAT
CAACCTGTCGAAACCATTCCTTCTCTTAGAGCAATGCCAAATATGCTAGTTTTTAGACCAGGAGATGGTAATGAAACTAG
TGGTGCTTATAAGATTGCTATTAAAAACAGAAAAAGGCCTTCAGCACTCTGCTTAAGTAGACAAGCCATGCCTAATCAAG
AGAACACCTCTATTGAAAAAGTTGCATTAGGTGGATACATAGTTTCCGATTGTGAAGGGACTCCTGAAGTAATATTTATC
GGTACTGGTAGTGAACTAAATTTGTGCATTGAGGCAAGTAAAGAAATCTCAAAATCAGGGACAAAAACAAGAGTTATTTC
AATGCCATGCGTAGAGCTATTTGAAGAGCAGGATCCCTCTTACAAAGAAAGTATTTTACCTAGCAGTGTCAAAAAAAGAG
TTGTAGTTGAAGCAGCACATTCATTCGGATGGCATAAATATACTGGACTTGATGGCATTTGTATAACTATGGATAGATTT
GGTGCCTCTGCTCCTGGCGGAAAATGTATGACCAGTTTCGGATTTACAGTTGAAAATGTTATAAATAAAACTAGAGAAAT
TTTATAG

Upstream 100 bases:

>100_bases
AAATTCATTCGGCTTTGGTGGTCACAATGTTTGTTTAGCTTTTAGCAAGCTTAATTGATGAAAACCAATTCTACATTCCC
AAATTATCTCATTTAAAACA

Downstream 100 bases:

>100_bases
GCGCCAACTAAACTTTAATGTCACATTTTGCGAGTTTATTATTCAATTGATCAAGTGTTTCATCAGAAATTTTTGAATTC
ATGGGGCAATGCTTAGGACC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCEIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVQGITKAIESAKS
VKDKPSLIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYTQFRQAITKGEESEKEWNLKFK
GYQNSYPSEGNELKRMIQGDLPENWDSDLPSYTPDDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQAHSPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKIAIKNRKRPSALCLSRQAMPNQENTSIEKVALGGYIVSDCEGTPEVIFI
GTGSELNLCIEASKEISKSGTKTRVISMPCVELFEEQDPSYKESILPSSVKKRVVVEAAHSFGWHKYTGLDGICITMDRF
GASAPGGKCMTSFGFTVENVINKTREIL

Sequences:

>Translated_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCEIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVQGITKAIESAKS
VKDKPSLIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYTQFRQAITKGEESEKEWNLKFK
GYQNSYPSEGNELKRMIQGDLPENWDSDLPSYTPDDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQAHSPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKIAIKNRKRPSALCLSRQAMPNQENTSIEKVALGGYIVSDCEGTPEVIFI
GTGSELNLCIEASKEISKSGTKTRVISMPCVELFEEQDPSYKESILPSSVKKRVVVEAAHSFGWHKYTGLDGICITMDRF
GASAPGGKCMTSFGFTVENVINKTREIL
>Mature_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCEIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVQGITKAIESAKS
VKDKPSLIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYTQFRQAITKGEESEKEWNLKFK
GYQNSYPSEGNELKRMIQGDLPENWDSDLPSYTPDDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGS
FQAHSPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKIAIKNRKRPSALCLSRQAMPNQENTSIEKVALGGYIVSDCEGTPEVIFI
GTGSELNLCIEASKEISKSGTKTRVISMPCVELFEEQDPSYKESILPSSVKKRVVVEAAHSFGWHKYTGLDGICITMDRF
GASAPGGKCMTSFGFTVENVINKTREIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=27.1331058020478, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=26.643598615917, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=26.643598615917, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI225637459, Length=588, Percent_Identity=23.6394557823129, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI225637463, Length=487, Percent_Identity=25.2566735112936, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI225637461, Length=487, Percent_Identity=25.2566735112936, Blast_Score=117, Evalue=5e-26,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=51.131221719457, Blast_Score=690, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=50.9803921568627, Blast_Score=680, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=582, Percent_Identity=25.085910652921, Blast_Score=148, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=51.7964071856287, Blast_Score=667, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=48.1371087928465, Blast_Score=632, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=676, Percent_Identity=25.7396449704142, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45550715, Length=676, Percent_Identity=25.7396449704142, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24645119, Length=647, Percent_Identity=25.6568778979907, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=25.085910652921, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72915; Mature: 72915

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCEIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHEEEHHHHHEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVQGITKAIESAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
VKDKPSLIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYTQ
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRQAITKGEESEKEWNLKFKGYQNSYPSEGNELKRMIQGDLPENWDSDLPSYTPDDKGLA
HHHHHHCCCCCCCEECEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQAHSPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
AAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKIAIKNRKRPSALCLSRQAMPNQENTSIEK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEE
VALGGYIVSDCEGTPEVIFIGTGSELNLCIEASKEISKSGTKTRVISMPCVELFEEQDPS
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHCCCCCEEEEECHHHHHHHCCCCC
YKESILPSSVKKRVVVEAAHSFGWHKYTGLDGICITMDRFGASAPGGKCMTSFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCHHHCCCHHHHH
INKTREIL
HHHHHHCC
>Mature Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIEDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCEIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHEEEHHHHHEECCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVQGITKAIESAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHH
VKDKPSLIKISTTIGYGSPNKSDTAGIHGAAVGEEEASLTREFLNWEYPPFEIPDEVYTQ
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRQAITKGEESEKEWNLKFKGYQNSYPSEGNELKRMIQGDLPENWDSDLPSYTPDDKGLA
HHHHHHCCCCCCCEECEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGETGSFQAHSPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHH
AAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPVETIPSLRAMPNMLVFRPGDGNETSGAYKIAIKNRKRPSALCLSRQAMPNQENTSIEK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEE
VALGGYIVSDCEGTPEVIFIGTGSELNLCIEASKEISKSGTKTRVISMPCVELFEEQDPS
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHCCCCCEEEEECHHHHHHHCCCCC
YKESILPSSVKKRVVVEAAHSFGWHKYTGLDGICITMDRFGASAPGGKCMTSFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCHHHCCCHHHHH
INKTREIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]