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The map label for this gene is fabF [H]

Identifier: 123967030

GI number: 123967030

Start: 1582627

End: 1583871

Strand: Direct

Name: fabF [H]

Synonym: P9515_17971

Alternate gene names: 123967030

Gene position: 1582627-1583871 (Clockwise)

Preceding gene: 123967029

Following gene: 123967031

Centisome position: 92.87

GC content: 40.16

Gene sequence:

>1245_bases
ATGCCAAATTTCCATCGAGTAGTTGTTACTGGTATTGGAGCAGTAACTCCAATCGGTAACAACATTGATGAATATTTACT
CGGCCTTCAAACAGGGACAAATGGAGTTTCAGGTATCACTCTTTTTAATCCTGAAGAACATCCCTGCAAATTTGCAGCAG
AAGTTAAAAATCTTCAACTCGAAAAATTCATTGAACCAAAAGAATCAAAAAGATGGGATCGCTTTTCTCAATTTGGGGTC
GTAGCGGCAAAACAAGCCTTCAATGATTCTGGACTTGAAATAAATGAATCAAATGCATCAAGGGTTGGTGTAATTATTGG
CTCAGGGGTAGGGGGCTTATTAACAATGGAAAGTCAAGCTCAAATATTGAGTCATAAAGGGCCTAGAAGAGTAAGTCCAT
TTACAGTTCCAATGATGATTCCCAATATGGCAACGGGCTTAGCTGCTATTGCTCTTGGAGCAAAAGGTCCCAGTTCTGCT
GTGTCTACAGCCTGTGCTGCAGGATCCAATGCCATTGGAGATTCTTATAGATTATTACAACTCGGAAAAGCAGATGTAAT
GATTTGCGGAGGAGCAGAGGCAAGTATCACTCCACTTGGCGTAGCAGGCTTTGCGAGCGCAAAAGCTCTATCTTTCAGAA
ATGATAGTCCCAAAACTGCAAGTAGACCTTTTGATGCTGAAAGAGATGGATTTGTGATAGGGGAAGGTTCTGGAATACTT
GTTTTGGAAACTTTAGAAAATGCAAAGAAAAGAAAAGCAAAAATCTACGCAGAAATTATTGGATATGGAACTACTTGTGA
TGCCCATCACATCACCTCACCTTCTCCGGGTGGGACTGGTGGAGCAGCAGCAATCAAGCTTGCCCTTGATGATGGTTCAA
TCACTCTTGATCAAGTTGATTACATAAATGCTCATGGAACTAGTACCGCAGCAAATGACAAAAATGAAACTTCTGCAATT
AAATCCATATTTAAAGACAGATCTTACCTTATTCCTGTAAGCTCTACTAAGTCGATGACTGGTCATCTGTTAGGGGGGTC
AGGAGGTATAGAAGCGGTAGCTTGTATTCTTTCTTTGACACATAATTTTATCCCTCCTACAATTAATTATGTTAATCCTG
ATCCAGATTGTGATCTGGATTATGTACCAAATCACGCCAGAGATGCTCAAATAAGAGTCGCTCTTTCAAATTCATTCGGC
TTTGGTGGTCACAATGTTTGTTTAGCTTTTAGCAAGCTTAATTGA

Upstream 100 bases:

>100_bases
AGAGGCATTTGATATCGAGATACCTGACGAAGCAGCTGAAGGTATAGCAACAGTAGGTGATGCTGTTAAATTCATCGAAG
CAAAAAAAGGTTAATTAAGG

Downstream 100 bases:

>100_bases
TGAAAACCAATTCTACATTCCCAAATTATCTCATTTAAAACAATGGTCGCTGCATCTGTTTCATTAGAATCTTTATGTGT
CAATAGTATAAGAATGTTAG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPNFHRVVVTGIGAVTPIGNNIDEYLLGLQTGTNGVSGITLFNPEEHPCKFAAEVKNLQLEKFIEPKESKRWDRFSQFGV
VAAKQAFNDSGLEINESNASRVGVIIGSGVGGLLTMESQAQILSHKGPRRVSPFTVPMMIPNMATGLAAIALGAKGPSSA
VSTACAAGSNAIGDSYRLLQLGKADVMICGGAEASITPLGVAGFASAKALSFRNDSPKTASRPFDAERDGFVIGEGSGIL
VLETLENAKKRKAKIYAEIIGYGTTCDAHHITSPSPGGTGGAAAIKLALDDGSITLDQVDYINAHGTSTAANDKNETSAI
KSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPDCDLDYVPNHARDAQIRVALSNSFG
FGGHNVCLAFSKLN

Sequences:

>Translated_414_residues
MPNFHRVVVTGIGAVTPIGNNIDEYLLGLQTGTNGVSGITLFNPEEHPCKFAAEVKNLQLEKFIEPKESKRWDRFSQFGV
VAAKQAFNDSGLEINESNASRVGVIIGSGVGGLLTMESQAQILSHKGPRRVSPFTVPMMIPNMATGLAAIALGAKGPSSA
VSTACAAGSNAIGDSYRLLQLGKADVMICGGAEASITPLGVAGFASAKALSFRNDSPKTASRPFDAERDGFVIGEGSGIL
VLETLENAKKRKAKIYAEIIGYGTTCDAHHITSPSPGGTGGAAAIKLALDDGSITLDQVDYINAHGTSTAANDKNETSAI
KSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPDCDLDYVPNHARDAQIRVALSNSFG
FGGHNVCLAFSKLN
>Mature_413_residues
PNFHRVVVTGIGAVTPIGNNIDEYLLGLQTGTNGVSGITLFNPEEHPCKFAAEVKNLQLEKFIEPKESKRWDRFSQFGVV
AAKQAFNDSGLEINESNASRVGVIIGSGVGGLLTMESQAQILSHKGPRRVSPFTVPMMIPNMATGLAAIALGAKGPSSAV
STACAAGSNAIGDSYRLLQLGKADVMICGGAEASITPLGVAGFASAKALSFRNDSPKTASRPFDAERDGFVIGEGSGILV
LETLENAKKRKAKIYAEIIGYGTTCDAHHITSPSPGGTGGAAAIKLALDDGSITLDQVDYINAHGTSTAANDKNETSAIK
SIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPDCDLDYVPNHARDAQIRVALSNSFGF
GGHNVCLAFSKLN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=425, Percent_Identity=42.5882352941177, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=44, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=24.2424242424242, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=50.9756097560976, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=36.4066193853428, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=32.2115384615385, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=35.2272727272727, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=425, Percent_Identity=25.8823529411765, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=24.7002398081535, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=36.0986547085202, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24644341, Length=414, Percent_Identity=42.7536231884058, Blast_Score=311, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24581345, Length=424, Percent_Identity=24.2924528301887, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221330659, Length=431, Percent_Identity=23.8979118329466, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19920632, Length=431, Percent_Identity=23.8979118329466, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43279; Mature: 43148

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFHRVVVTGIGAVTPIGNNIDEYLLGLQTGTNGVSGITLFNPEEHPCKFAAEVKNLQL
CCCCEEEEEEECCEECCCCCCHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCH
EKFIEPKESKRWDRFSQFGVVAAKQAFNDSGLEINESNASRVGVIIGSGVGGLLTMESQA
HHHCCCCHHHHHHHHHHHCHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCEEEECHHH
QILSHKGPRRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVSTACAAGSNAIGDSYRLLQ
HHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCEEEEE
LGKADVMICGGAEASITPLGVAGFASAKALSFRNDSPKTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAKKRKAKIYAEIIGYGTTCDAHHITSPSPGGTGGAAAIKLALDDGSITLDQVD
EEHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
YINAHGTSTAANDKNETSAIKSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNPDPDCDLDYVPNHARDAQIRVALSNSFGFGGHNVCLAFSKLN
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
PNFHRVVVTGIGAVTPIGNNIDEYLLGLQTGTNGVSGITLFNPEEHPCKFAAEVKNLQL
CCCEEEEEEECCEECCCCCCHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCH
EKFIEPKESKRWDRFSQFGVVAAKQAFNDSGLEINESNASRVGVIIGSGVGGLLTMESQA
HHHCCCCHHHHHHHHHHHCHHHHHHHCCCCCCEEECCCCCEEEEEEECCCCCEEEECHHH
QILSHKGPRRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVSTACAAGSNAIGDSYRLLQ
HHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCHHHHHHHHCCCCCCCCCEEEEE
LGKADVMICGGAEASITPLGVAGFASAKALSFRNDSPKTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAKKRKAKIYAEIIGYGTTCDAHHITSPSPGGTGGAAAIKLALDDGSITLDQVD
EEHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
YINAHGTSTAANDKNETSAIKSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNPDPDCDLDYVPNHARDAQIRVALSNSFGFGGHNVCLAFSKLN
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]