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The map label for this gene is hemF

Identifier: 123967002

GI number: 123967002

Start: 1557131

End: 1558159

Strand: Direct

Name: hemF

Synonym: P9515_17691

Alternate gene names: 123967002

Gene position: 1557131-1558159 (Clockwise)

Preceding gene: 123966991

Following gene: 123967004

Centisome position: 91.37

GC content: 34.6

Gene sequence:

>1029_bases
ATGTCTAAAGAACCCCCTAATAATTCAAGAGAAAAGACTAAGAATCTCTTACTAAAATTACAAGATAATATTTGCAAAAA
CCTGGAAAATATTGATGGGAAAGCAAAATTCACTGAGGAATCTTGGCTTAGAGAAGAAGGTGGAGGAGGGAGATCTAGAG
TTTTAAAAAATGGCTCGATTTTTGAGCAGGCTGGAGTCAATTTCTCAGAGGTATATGGTAAAGAGCTTCCTCAGTCAATC
ATCTCACAAAGACCAGAAGCTAAAGGTCACGAATGGTTTGCCACCGGCACATCAATGGTATTGCATCCTAAAAATCCTTT
CATACCCACAGTTCATCTTAATTATCGTTATTTCGAGGCAGGACCAGTTTGGTGGTTTGGTGGAGGTGCCGATCTGACTC
CATATTACCCTTATTTATCTGATGTGAGACATTTTCATAAAGAGCATAGTAATGCCTGTGAAAAAGTTAATAAAAAACTT
CACCTGGTATTCAAGCCATGGTGTGATGAATATTTCTTTTTGAAACACAGAAATGAATCAAGAGGAATTGGAGGTATCTT
TTATGACTATCAAGATGGTTCCGGTAATATCTATAAAGGCAGCAACAAAGATGGCAATGCCTACAAAGAATCTAATAATA
TTGGCGAGTTAAACTTAAATTGGAATAATTTATTTGCATTAGCAGAAAATTGTGGAGAAGCATTTTTAAGTTCATATCAA
CCGATAATTGAAAAAAGAGTCAGCCAAAACTACACAAAAGAAGAGAGAGAATTTCAACTTTATAGAAGAGGACGATACGT
TGAATTTAATTTAGTTTGGGACAGAGGAACAATTTTTGGATTACAAACAAATGGTAGAACTGAATCTATATTAATGTCAT
TGCCACCCCTAGCTAGATGGGAATATGGTTATAAAGCCAAGCAAGGATCTAGAGAAGATTTACTCACTAAAATTTTTACA
AGGCCTCAAGATTGGCAAAATGATAAGGTTTTAGAAGAATTTTGTTTAGAAAATAATATTTTTGATTAA

Upstream 100 bases:

>100_bases
GAACTATCAAATAATAAGAAATTACTCCCCCTTAAAGGAAATTATAAAGGGAAACGACTAATTAACCAAAAATTTAATTC
TTCAATCTCAAGTTAAATAA

Downstream 100 bases:

>100_bases
ATATTCTCAAAATTCTGAAGTAATTTTTACTAGATAGGTGTTTTAAACAAAGAACCATCACTTTTTAATTTGAGCCTATC
ACTCAGTTCATTTTCAAGAG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSIFEQAGVNFSEVYGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKL
HLVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQ
PIIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKQGSREDLLTKIFT
RPQDWQNDKVLEEFCLENNIFD

Sequences:

>Translated_342_residues
MSKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSIFEQAGVNFSEVYGKELPQSI
ISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKL
HLVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQ
PIIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKQGSREDLLTKIFT
RPQDWQNDKVLEEFCLENNIFD
>Mature_341_residues
SKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSIFEQAGVNFSEVYGKELPQSII
SQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKLH
LVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQP
IIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKQGSREDLLTKIFTR
PQDWQNDKVLEEFCLENNIFD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=333, Percent_Identity=41.4414414414414, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1788777, Length=320, Percent_Identity=50.3125, Blast_Score=328, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6320249, Length=340, Percent_Identity=42.9411764705882, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17864388, Length=331, Percent_Identity=43.202416918429, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_PROM5 (A2BYW5)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012083.1
- ProteinModelPortal:   A2BYW5
- SMR:   A2BYW5
- STRING:   A2BYW5
- GeneID:   4719892
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_17691
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   VFKPWCD
- ProtClustDB:   PRK05330
- BioCyc:   PMAR167542:P9515ORF_1845-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 39764; Mature: 39633

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 112-112 BINDING 98-98

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCCHHHEECCCCC
FEQAGVNFSEVYGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEA
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKLHLVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQ
CCCCEEEEEEECCCCCEEECCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
PIIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCCCEEECCCHHHC
EYGYKAKQGSREDLLTKIFTRPQDWQNDKVLEEFCLENNIFD
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKEPPNNSREKTKNLLLKLQDNICKNLENIDGKAKFTEESWLREEGGGGRSRVLKNGSI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHCCCCCHHHEECCCCC
FEQAGVNFSEVYGKELPQSIISQRPEAKGHEWFATGTSMVLHPKNPFIPTVHLNYRYFEA
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCEEEEEEEEEEC
GPVWWFGGGADLTPYYPYLSDVRHFHKEHSNACEKVNKKLHLVFKPWCDEYFFLKHRNES
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEECCCC
RGIGGIFYDYQDGSGNIYKGSNKDGNAYKESNNIGELNLNWNNLFALAENCGEAFLSSYQ
CCCCEEEEEEECCCCCEEECCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHH
PIIEKRVSQNYTKEEREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARW
HHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCCCCCCCEEECCCHHHC
EYGYKAKQGSREDLLTKIFTRPQDWQNDKVLEEFCLENNIFD
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA