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The map label for this gene is degP [C]

Identifier: 123966903

GI number: 123966903

Start: 1464257

End: 1465387

Strand: Reverse

Name: degP [C]

Synonym: P9515_16701

Alternate gene names: 123966903

Gene position: 1465387-1464257 (Counterclockwise)

Preceding gene: 123966908

Following gene: 123966902

Centisome position: 85.99

GC content: 35.01

Gene sequence:

>1131_bases
ATGAGATTTTTAAAAAATAAATTTATTTATTTATTTAAATTGGGCATCGTGCTATTTGCTTTTTTAATTAATTTTTTGCC
TTTGTCTGAAGTTTTTGCTTTAAATTCTCTCGATGGGCATAATTTCGTATCGGACGCAGTTAAAAATGTAGGTCCTGCAG
TGGTTAGAATTGATACTGAAAGATTAGTAGAAAGACAACAGTTTGATCCAACTTTATTAGATCCATTATTAAGAGATTTA
CTAGGGGAACCCGGAATGGCTCCTGACAGAGAAAGAGGTCAAGGTTCAGGTGTGATAATTAACAAAAATGGTTTGGTTTT
AACAAATGCTCATGTTGTAGAAAGAGTTGATAATGTGTCAGTGACGTTGGCGGATGGAACTAATTGTGATGGGAAAGTAT
TGGGAACCGATTCGATTACTGATTTAGCGTTAGTTAAAATCGAACAACTTATTGATTCAAGTTATGCTCCTTTAGGAGAT
TCAGAGAAACTTGAAGTTGGGGATTGGGCAATAGCTCTTGGTACGCCGTATGGCCTTGAGAAAACAGTTACTCTTGGCAT
AGTTAGCAGTCTGCATAGAGATATCAATTCACTAGGTTTTTCTGATAAAAGGCTTGATCTAATTCAAACAGATGCCGCAA
TTAACCCAGGTAATTCTGGAGGTCCGCTCATAAATTCTAATGGCCAGGTTATTGGCATAAATACACTCGTTAGAAGTGGA
CCTGGAGCTGGCCTAGGTTTTGCAATACCTATAAATTTAGCTAAAAATGTTTCTGACCAATTATTAGAGAATGGTGAAGT
TATTCATCCTTATTTAGGAGTACAATTAATATCCTTAAATCCTAAAATGGCTAAACAACACAACGAAGATCCTAATGCAA
TTGTTCAATTACCCGAGAGGTCCGGAGCTTTAATTCAGTCTATAGTTCCAAATAGTCCTGCAGAAAAAGCAGGTTTGAAA
AGAGGTGACTTAGTAATTGCAGCTGAAAATATATCAATAGAAGAACCAAAAACTCTTTTAGATGAAGTAGAAAAAGCTCA
AATTGGAAAAGTATTTCTTTTAAATGTTGTGAGGGATAATAAAGAAATCAAAGTTAATATTAAACCTGAAGCACTTCCAG
GTTTGACATAA

Upstream 100 bases:

>100_bases
AATTTTTTATCAATGTATTTTATGGATGTAAACAAAAAAACAACACTAGGAAAGTTATTCAATTAAATTTTAAATAGATA
TTAAATATTCAAAAAAGAAA

Downstream 100 bases:

>100_bases
ATCATTTGTTGAAATTTAATAATCTATAAACTTTACGCTAAAAACATTTTGGATTTACAGACTCAGATGAAACAAATAGT
TGCTGATGCAGCTGTTAAAG

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MRFLKNKFIYLFKLGIVLFAFLINFLPLSEVFALNSLDGHNFVSDAVKNVGPAVVRIDTERLVERQQFDPTLLDPLLRDL
LGEPGMAPDRERGQGSGVIINKNGLVLTNAHVVERVDNVSVTLADGTNCDGKVLGTDSITDLALVKIEQLIDSSYAPLGD
SEKLEVGDWAIALGTPYGLEKTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINSNGQVIGINTLVRSG
PGAGLGFAIPINLAKNVSDQLLENGEVIHPYLGVQLISLNPKMAKQHNEDPNAIVQLPERSGALIQSIVPNSPAEKAGLK
RGDLVIAAENISIEEPKTLLDEVEKAQIGKVFLLNVVRDNKEIKVNIKPEALPGLT

Sequences:

>Translated_376_residues
MRFLKNKFIYLFKLGIVLFAFLINFLPLSEVFALNSLDGHNFVSDAVKNVGPAVVRIDTERLVERQQFDPTLLDPLLRDL
LGEPGMAPDRERGQGSGVIINKNGLVLTNAHVVERVDNVSVTLADGTNCDGKVLGTDSITDLALVKIEQLIDSSYAPLGD
SEKLEVGDWAIALGTPYGLEKTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINSNGQVIGINTLVRSG
PGAGLGFAIPINLAKNVSDQLLENGEVIHPYLGVQLISLNPKMAKQHNEDPNAIVQLPERSGALIQSIVPNSPAEKAGLK
RGDLVIAAENISIEEPKTLLDEVEKAQIGKVFLLNVVRDNKEIKVNIKPEALPGLT
>Mature_376_residues
MRFLKNKFIYLFKLGIVLFAFLINFLPLSEVFALNSLDGHNFVSDAVKNVGPAVVRIDTERLVERQQFDPTLLDPLLRDL
LGEPGMAPDRERGQGSGVIINKNGLVLTNAHVVERVDNVSVTLADGTNCDGKVLGTDSITDLALVKIEQLIDSSYAPLGD
SEKLEVGDWAIALGTPYGLEKTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINSNGQVIGINTLVRSG
PGAGLGFAIPINLAKNVSDQLLENGEVIHPYLGVQLISLNPKMAKQHNEDPNAIVQLPERSGALIQSIVPNSPAEKAGLK
RGDLVIAAENISIEEPKTLLDEVEKAQIGKVFLLNVVRDNKEIKVNIKPEALPGLT

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=344, Percent_Identity=35.1744186046512, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI22129776, Length=347, Percent_Identity=31.700288184438, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7019477, Length=343, Percent_Identity=31.1953352769679, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI24308541, Length=343, Percent_Identity=31.7784256559767, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=40.2877697841727, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI1789629, Length=325, Percent_Identity=36.3076923076923, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1789630, Length=288, Percent_Identity=35.0694444444444, Blast_Score=162, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646839, Length=383, Percent_Identity=31.8537859007833, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40430; Mature: 40430

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLKNKFIYLFKLGIVLFAFLINFLPLSEVFALNSLDGHNFVSDAVKNVGPAVVRIDTE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECHH
RLVERQQFDPTLLDPLLRDLLGEPGMAPDRERGQGSGVIINKNGLVLTNAHVVERVDNVS
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEECHHHHHHCCCCE
VTLADGTNCDGKVLGTDSITDLALVKIEQLIDSSYAPLGDSEKLEVGDWAIALGTPYGLE
EEEECCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEECCCCCCC
KTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINSNGQVIGINTLVRSG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEHHHHCC
PGAGLGFAIPINLAKNVSDQLLENGEVIHPYLGVQLISLNPKMAKQHNEDPNAIVQLPER
CCCCCEEEEEHHHHHCHHHHHHHCCCEEEHHHCEEEEECCHHHHHHCCCCCCCEEECCCC
SGALIQSIVPNSPAEKAGLKRGDLVIAAENISIEEPKTLLDEVEKAQIGKVFLLNVVRDN
CCHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEECC
KEIKVNIKPEALPGLT
CEEEEEECCCCCCCCC
>Mature Secondary Structure
MRFLKNKFIYLFKLGIVLFAFLINFLPLSEVFALNSLDGHNFVSDAVKNVGPAVVRIDTE
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECHH
RLVERQQFDPTLLDPLLRDLLGEPGMAPDRERGQGSGVIINKNGLVLTNAHVVERVDNVS
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEECHHHHHHCCCCE
VTLADGTNCDGKVLGTDSITDLALVKIEQLIDSSYAPLGDSEKLEVGDWAIALGTPYGLE
EEEECCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEECCCCCCC
KTVTLGIVSSLHRDINSLGFSDKRLDLIQTDAAINPGNSGGPLINSNGQVIGINTLVRSG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEEHHHHCC
PGAGLGFAIPINLAKNVSDQLLENGEVIHPYLGVQLISLNPKMAKQHNEDPNAIVQLPER
CCCCCEEEEEHHHHHCHHHHHHHCCCEEEHHHCEEEEECCHHHHHHCCCCCCCEEECCCC
SGALIQSIVPNSPAEKAGLKRGDLVIAAENISIEEPKTLLDEVEKAQIGKVFLLNVVRDN
CCHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEEECC
KEIKVNIKPEALPGLT
CEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA