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The map label for this gene is serA [H]

Identifier: 123966748

GI number: 123966748

Start: 1348370

End: 1349956

Strand: Reverse

Name: serA [H]

Synonym: P9515_15151

Alternate gene names: 123966748

Gene position: 1349956-1348370 (Counterclockwise)

Preceding gene: 123966754

Following gene: 123966747

Centisome position: 79.21

GC content: 37.37

Gene sequence:

>1587_bases
ATGACAAAAGTTCTAATTACCGATCCAATTGATCAAACTGGAATTGATATTCTTTCCCAAGTCGCTCAAGTTGATCAGAG
AATAGGAATCTCCAACCTTGAATTGGCATCTATTATCCAAGACTATGATGCTCTTATGATACGTTCTGGGACTCAAGTTA
CAGGAGATATTATTAATTCTTCTAAAAAACTAAGAATAATTGGCAGGGCTGGGGTTGGTGTAGATAATGTTGATGTTAAG
GCTGCTACTCAGAAGGGTGTATTGGTTGTTAATTCTCCAGGAGGAAATACAATAGCTGCTGCCGAGCATACAATTGCAAT
GATGTTGGCATTATCTAGAAATATACCGATTGCTAACAGTAGTACTTTTTTAGGTAAATGGGAAAGGAAAAAGTTTGTTG
GTAATGAACTCTTTAAGAAAAAGCTAGGTGTTGTGGGTTTGGGAAAAATAGGTACTCATGTCGCAAAAGTTGCTAATGCG
CTTGGAATGGATGTTTATGGATATGATCCTTTTGTTTCCTCAGAGAGAGCACAACAATTACAGGTCAAATTGTCCGAATT
GAAAACATTGTTTGCTGAATCTGATTATGTAAGTTTACATTTGCCGAGGACTTCAGAAACAGAAAACTTGGTAGATATGA
AAGTGTTAAAAAGTATGAAAGATAATGCGAAATTAATAAACTGTGCTCGAGGGGGAATAATTGATGAAGAAGCTTTAGCT
GAGGCGCTTAATAAGTCATTGATTGGAGGAGCAGCTATTGATGTGTTTGCTGAAGAGCCATTAGATTCTAATTCACCATT
ACTTAAAGTTGATAAAAATTTAATCCTTACTCCTCATTTAGGAGCCTCAACAAGGGAGGCTCAAGAGAATGTTGCAGTAG
ATGTTGCGGAACAAATAAGAGATGTTCTTTTGGGCCTTTCTGCAAGAACAGCAGTAAATATTCCTGGTTTAAGTCCTGAT
ATTATGGATAGCCTTAAACCTCATTTACAATTAGCTGAAACAATGGGTCTTTTAATAAGCCAACTTTCTGGAGGAAAAAT
TCAAAAGTTAGACCTAAGGCTTCAAGGCGAATTTGTACAGCACCCTTCTCAGCCCTTAATTATAGCAAGTTTAAAAGGCC
TATTAAGTAAAGCGCTTGGAGATCGAATTAATTATGTTAACGCGTCTCTTGAGGCGGAATCAAGGGGTATTTCAGTGGTT
GAAAGTAAAGATGAGGCTAGACCTGAATTTGCTAGCGGCTCACTCCAATTAACTACATTCGGAGATAATGGAGAGCATAG
TGTTGCAGGAAGTATTTTTGCCGATGGTGAATTAAGAATAATTAGCATTGATCAGTATCCAGTTAATGTTTCTCCAAGTA
GATTTATGCTTATAACTAGGCATAGAGATATGCCTGGCATTATTGGAAAGTTAGGTTCCCTCTTGGGGGACCACAATGTC
AATATTGCTTCAATGCAAGTTGGTAGAAAAATTGTCAGAGGAGAAGCTGTTATGGTTTTAAGTATTGATGATCCGATCCC
CACAAATTTGCTTGAATCGATTCTTGAAGTTGAGGGTATTACTAGTTCCGATCCAGTAACTTTGTAA

Upstream 100 bases:

>100_bases
TTTCATTCCTCAAATGTTGGTTTGTTGATTCAAATAAAAAAAATAAGATATCTCTACTATAGATTAAGTTAAAGTAAAAA
ATTAAAGAACAACTCTTTAA

Downstream 100 bases:

>100_bases
ATACTCTAAGAGTTTAATGGAAATAAATTATTGGTATAAACTCACCTTTGAAATAGAAGCTAATTTAGAAGAGATCATTA
TTTGGAAATTAAACGAATTA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNLELASIIQDYDALMIRSGTQVTGDIINSSKKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTFLGKWERKKFVGNELFKKKLGVVGLGKIGTHVAKVANA
LGMDVYGYDPFVSSERAQQLQVKLSELKTLFAESDYVSLHLPRTSETENLVDMKVLKSMKDNAKLINCARGGIIDEEALA
EALNKSLIGGAAIDVFAEEPLDSNSPLLKVDKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGKIQKLDLRLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEAESRGISVV
ESKDEARPEFASGSLQLTTFGDNGEHSVAGSIFADGELRIISIDQYPVNVSPSRFMLITRHRDMPGIIGKLGSLLGDHNV
NIASMQVGRKIVRGEAVMVLSIDDPIPTNLLESILEVEGITSSDPVTL

Sequences:

>Translated_528_residues
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNLELASIIQDYDALMIRSGTQVTGDIINSSKKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTFLGKWERKKFVGNELFKKKLGVVGLGKIGTHVAKVANA
LGMDVYGYDPFVSSERAQQLQVKLSELKTLFAESDYVSLHLPRTSETENLVDMKVLKSMKDNAKLINCARGGIIDEEALA
EALNKSLIGGAAIDVFAEEPLDSNSPLLKVDKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGKIQKLDLRLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEAESRGISVV
ESKDEARPEFASGSLQLTTFGDNGEHSVAGSIFADGELRIISIDQYPVNVSPSRFMLITRHRDMPGIIGKLGSLLGDHNV
NIASMQVGRKIVRGEAVMVLSIDDPIPTNLLESILEVEGITSSDPVTL
>Mature_527_residues
TKVLITDPIDQTGIDILSQVAQVDQRIGISNLELASIIQDYDALMIRSGTQVTGDIINSSKKLRIIGRAGVGVDNVDVKA
ATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANSSTFLGKWERKKFVGNELFKKKLGVVGLGKIGTHVAKVANAL
GMDVYGYDPFVSSERAQQLQVKLSELKTLFAESDYVSLHLPRTSETENLVDMKVLKSMKDNAKLINCARGGIIDEEALAE
ALNKSLIGGAAIDVFAEEPLDSNSPLLKVDKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPDI
MDSLKPHLQLAETMGLLISQLSGGKIQKLDLRLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEAESRGISVVE
SKDEARPEFASGSLQLTTFGDNGEHSVAGSIFADGELRIISIDQYPVNVSPSRFMLITRHRDMPGIIGKLGSLLGDHNVN
IASMQVGRKIVRGEAVMVLSIDDPIPTNLLESILEVEGITSSDPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=40, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=35.7933579335793, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=35.7933579335793, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI145580578, Length=286, Percent_Identity=34.2657342657343, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557499, Length=286, Percent_Identity=34.2657342657343, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI145580575, Length=286, Percent_Identity=34.2657342657343, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=27.0096463022508, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=35.9133126934984, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=31.5972222222222, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.7142857142857, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=29.6577946768061, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081824, Length=252, Percent_Identity=26.1904761904762, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=41.1764705882353, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=30.4347826086957, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=33.4355828220859, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=32.7327327327327, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=27.8225806451613, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=28.515625, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=178, Percent_Identity=30.3370786516854, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=40, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=36.2264150943396, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=36.2264150943396, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=36.2264150943396, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=36.2264150943396, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=36.2264150943396, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574286, Length=331, Percent_Identity=30.8157099697885, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=28.7461773700306, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=28.7461773700306, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=327, Percent_Identity=28.7461773700306, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574282, Length=327, Percent_Identity=28.7461773700306, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=28.7461773700306, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=28.525641025641, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=25.7234726688103, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56594; Mature: 56463

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLITDPIDQTGIDILSQVAQVDQRIGISNLELASIIQDYDALMIRSGTQVTGDIINS
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCEEEHHHHCC
SKKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCC
STFLGKWERKKFVGNELFKKKLGVVGLGKIGTHVAKVANALGMDVYGYDPFVSSERAQQL
CCHHCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QVKLSELKTLFAESDYVSLHLPRTSETENLVDMKVLKSMKDNAKLINCARGGIIDEEALA
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHH
EALNKSLIGGAAIDVFAEEPLDSNSPLLKVDKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGKIQKLDLRLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEAESRGISVVESKDEARPEFASGSLQLTTF
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEC
GDNGEHSVAGSIFADGELRIISIDQYPVNVSPSRFMLITRHRDMPGIIGKLGSLLGDHNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPTNLLESILEVEGITSSDPVTL
EEEHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKVLITDPIDQTGIDILSQVAQVDQRIGISNLELASIIQDYDALMIRSGTQVTGDIINS
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCEEEHHHHCC
SKKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRNIPIANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCC
STFLGKWERKKFVGNELFKKKLGVVGLGKIGTHVAKVANALGMDVYGYDPFVSSERAQQL
CCHHCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QVKLSELKTLFAESDYVSLHLPRTSETENLVDMKVLKSMKDNAKLINCARGGIIDEEALA
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHH
EALNKSLIGGAAIDVFAEEPLDSNSPLLKVDKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGKIQKLDLRLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEAESRGISVVESKDEARPEFASGSLQLTTF
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEC
GDNGEHSVAGSIFADGELRIISIDQYPVNVSPSRFMLITRHRDMPGIIGKLGSLLGDHNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPTNLLESILEVEGITSSDPVTL
EEEHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]