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The map label for this gene is manC [H]

Identifier: 123966603

GI number: 123966603

Start: 1203838

End: 1205280

Strand: Direct

Name: manC [H]

Synonym: P9515_13701

Alternate gene names: 123966603

Gene position: 1203838-1205280 (Clockwise)

Preceding gene: 123966602

Following gene: 123966604

Centisome position: 70.64

GC content: 30.84

Gene sequence:

>1443_bases
ATGGAACAAAAAATAATTCCTATAATTTTATGTGGAGGGAAAGGAACTAGATTATGGCCGCTTTCTAGACAGAGTTATCC
AAAACAATTTTTAGCTTTGCACGGAGATAAGAATAAGTCCCTTTTACAACAGACTCAGGAGAGAATATCTTTTTTAGAAG
GTATTACTGAGCCAATAATAATTTGTAATGAGGAGCATAGATTCTTAGTAGCAGAACAAATGAGAGATATAAATGTAAAA
CCAAAAGCAATAATACTTGAAAATGAAGGTAAAAATACAGCCCCAGCAATTGCTCTTGGAGCTATAAAAGCTTTAGAAGA
AGAGCAAGAAGATCCATTATTGTTAATATTATCTGCGGATCATATAATTAGAGATCTAAATGTTTTCTCAAAAGTTTTAC
AAAAAGGATGTAAGTCAGCATTAGAAAATAATTTAGTTACATTTGGAATAATTCCTAATCGCCCAGAAACAGGTTATGGA
TATATAGAAAGTGAATTCGTTCTTGATAAAAATAATATTAAAGGTAGTCGTATTAAAAGATTTATCGAGAAGCCAAACAA
AGAATTAGCTCAAAAACTTGTCAAGTCAAATAAATATACTTGGAATAGTGGAATGTTCGTTTTCAAAAATAGCTTAATTA
TTAAAGAACTCAATAAACATGCACCCTTAGTTTTACGATATTGCAAAAAAGCAATAGGTAGTAGTGTTAGAGATCTTGAT
TTTATAAGAATTGATGGAGATTCTTTCTCTAAATCTCCTAATATCCCAATAGATATTGCCGTTATGGAAAAAACTAATTT
AGGTTTAGTTCTTCCCTTAGATGCAGGATGGAGTGATATTGGTAATTGGGAATCATTATGGGATAACGAAAAGAAAGATT
CTTTTGGCAATGTAATTAAAGGTAAAGTTTTTAATGAGGGATCAACTGACTGCTATATCAAAAGTGAGAATAGTCTTTTA
GTTACTCTGGGTTTAAAAGATTTAATACTTGTTGAGACTTCTGATGCAATACTTGCTGCTAACAAAAATGAATTAAATAA
AATAAAAACAGTATTAAATAAACTTGAAAAAAAAGGATACACGGAGGTCAATACACATAGAAAGATATATCGACCATGGG
GTTCATATACTTCTTTAATAGAGAATGAAAAGTGGCTTGTTAAAAGTATTGAAGTCAATCCCGGATCAAAACTCTCCCTA
CAAATGCATCATCATAGGACTGAACATTGGATAGTAGTGAAAGGAACCGCACAAGTTGAATTAGACAATAGAAGTTTCGT
TTTAAGTGAAAATCAAAGTACTTTCATCCCTTTAGGTTCAAAGCATAGATTAAGTAATCCTGGAAAAATTGATTTAACTC
TAATTGAAATTCAGAGTGGAGATTATATTGGAGAGGATGATATTGTAAGGTTCAAAGACGATTACGGTAGAATAAATGAT
TAA

Upstream 100 bases:

>100_bases
AATTTGGTAACTATGCTGTAAACATTTAAAAATTAGATTTTTATTAATTGAGTTAATAAAAATCTTTGTAGTAATATTTT
AATAATGTAGTTTAATATTA

Downstream 100 bases:

>100_bases
AATAAGATTTTTATGGAAGAAAAAATATTAGTCACTGGTTGTGCAGGTTTTATAGGATTTCATGTATGTAAACAATTAAT
CAAAAAGGGGTTATTTGTTA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MEQKIIPIILCGGKGTRLWPLSRQSYPKQFLALHGDKNKSLLQQTQERISFLEGITEPIIICNEEHRFLVAEQMRDINVK
PKAIILENEGKNTAPAIALGAIKALEEEQEDPLLLILSADHIIRDLNVFSKVLQKGCKSALENNLVTFGIIPNRPETGYG
YIESEFVLDKNNIKGSRIKRFIEKPNKELAQKLVKSNKYTWNSGMFVFKNSLIIKELNKHAPLVLRYCKKAIGSSVRDLD
FIRIDGDSFSKSPNIPIDIAVMEKTNLGLVLPLDAGWSDIGNWESLWDNEKKDSFGNVIKGKVFNEGSTDCYIKSENSLL
VTLGLKDLILVETSDAILAANKNELNKIKTVLNKLEKKGYTEVNTHRKIYRPWGSYTSLIENEKWLVKSIEVNPGSKLSL
QMHHHRTEHWIVVKGTAQVELDNRSFVLSENQSTFIPLGSKHRLSNPGKIDLTLIEIQSGDYIGEDDIVRFKDDYGRIND

Sequences:

>Translated_480_residues
MEQKIIPIILCGGKGTRLWPLSRQSYPKQFLALHGDKNKSLLQQTQERISFLEGITEPIIICNEEHRFLVAEQMRDINVK
PKAIILENEGKNTAPAIALGAIKALEEEQEDPLLLILSADHIIRDLNVFSKVLQKGCKSALENNLVTFGIIPNRPETGYG
YIESEFVLDKNNIKGSRIKRFIEKPNKELAQKLVKSNKYTWNSGMFVFKNSLIIKELNKHAPLVLRYCKKAIGSSVRDLD
FIRIDGDSFSKSPNIPIDIAVMEKTNLGLVLPLDAGWSDIGNWESLWDNEKKDSFGNVIKGKVFNEGSTDCYIKSENSLL
VTLGLKDLILVETSDAILAANKNELNKIKTVLNKLEKKGYTEVNTHRKIYRPWGSYTSLIENEKWLVKSIEVNPGSKLSL
QMHHHRTEHWIVVKGTAQVELDNRSFVLSENQSTFIPLGSKHRLSNPGKIDLTLIEIQSGDYIGEDDIVRFKDDYGRIND
>Mature_480_residues
MEQKIIPIILCGGKGTRLWPLSRQSYPKQFLALHGDKNKSLLQQTQERISFLEGITEPIIICNEEHRFLVAEQMRDINVK
PKAIILENEGKNTAPAIALGAIKALEEEQEDPLLLILSADHIIRDLNVFSKVLQKGCKSALENNLVTFGIIPNRPETGYG
YIESEFVLDKNNIKGSRIKRFIEKPNKELAQKLVKSNKYTWNSGMFVFKNSLIIKELNKHAPLVLRYCKKAIGSSVRDLD
FIRIDGDSFSKSPNIPIDIAVMEKTNLGLVLPLDAGWSDIGNWESLWDNEKKDSFGNVIKGKVFNEGSTDCYIKSENSLL
VTLGLKDLILVETSDAILAANKNELNKIKTVLNKLEKKGYTEVNTHRKIYRPWGSYTSLIENEKWLVKSIEVNPGSKLSL
QMHHHRTEHWIVVKGTAQVELDNRSFVLSENQSTFIPLGSKHRLSNPGKIDLTLIEIQSGDYIGEDDIVRFKDDYGRIND

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=479, Percent_Identity=47.3903966597077, Blast_Score=464, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 54379; Mature: 54379

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKIIPIILCGGKGTRLWPLSRQSYPKQFLALHGDKNKSLLQQTQERISFLEGITEPII
CCCCEEEEEEECCCCCEEEECCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEE
ICNEEHRFLVAEQMRDINVKPKAIILENEGKNTAPAIALGAIKALEEEQEDPLLLILSAD
EECCCCCEEEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECH
HIIRDLNVFSKVLQKGCKSALENNLVTFGIIPNRPETGYGYIESEFVLDKNNIKGSRIKR
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHH
FIEKPNKELAQKLVKSNKYTWNSGMFVFKNSLIIKELNKHAPLVLRYCKKAIGSSVRDLD
HHHCCCHHHHHHHHHCCCEEECCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCEE
FIRIDGDSFSKSPNIPIDIAVMEKTNLGLVLPLDAGWSDIGNWESLWDNEKKDSFGNVIK
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCHHCCEEE
GKVFNEGSTDCYIKSENSLLVTLGLKDLILVETSDAILAANKNELNKIKTVLNKLEKKGY
CEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCC
TEVNTHRKIYRPWGSYTSLIENEKWLVKSIEVNPGSKLSLQMHHHRTEHWIVVKGTAQVE
CCCCCCCCEECCCCHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEEEEEEE
LDNRSFVLSENQSTFIPLGSKHRLSNPGKIDLTLIEIQSGDYIGEDDIVRFKDDYGRIND
ECCCEEEEECCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MEQKIIPIILCGGKGTRLWPLSRQSYPKQFLALHGDKNKSLLQQTQERISFLEGITEPII
CCCCEEEEEEECCCCCEEEECCCCCCCCHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEE
ICNEEHRFLVAEQMRDINVKPKAIILENEGKNTAPAIALGAIKALEEEQEDPLLLILSAD
EECCCCCEEEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECH
HIIRDLNVFSKVLQKGCKSALENNLVTFGIIPNRPETGYGYIESEFVLDKNNIKGSRIKR
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHH
FIEKPNKELAQKLVKSNKYTWNSGMFVFKNSLIIKELNKHAPLVLRYCKKAIGSSVRDLD
HHHCCCHHHHHHHHHCCCEEECCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCEE
FIRIDGDSFSKSPNIPIDIAVMEKTNLGLVLPLDAGWSDIGNWESLWDNEKKDSFGNVIK
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHCCCCCCCHHCCEEE
GKVFNEGSTDCYIKSENSLLVTLGLKDLILVETSDAILAANKNELNKIKTVLNKLEKKGY
CEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCC
TEVNTHRKIYRPWGSYTSLIENEKWLVKSIEVNPGSKLSLQMHHHRTEHWIVVKGTAQVE
CCCCCCCCEECCCCHHHHHHCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEEEEEEE
LDNRSFVLSENQSTFIPLGSKHRLSNPGKIDLTLIEIQSGDYIGEDDIVRFKDDYGRIND
ECCCEEEEECCCCEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]