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The map label for this gene is fcl [H]

Identifier: 123966602

GI number: 123966602

Start: 1202563

End: 1203561

Strand: Direct

Name: fcl [H]

Synonym: P9515_13691

Alternate gene names: 123966602

Gene position: 1202563-1203561 (Clockwise)

Preceding gene: 123966601

Following gene: 123966603

Centisome position: 70.57

GC content: 31.53

Gene sequence:

>999_bases
ATGACACTAATAAATAAGGAAGAAAAAATATTTATAGCTGGGGGAAGTGGAATGGTTGGAAGTGCCATAATAAGAAAGTT
GAATAATTTAGGATTTAAACATTTAATTTTCCCTAATAGTTCTGAACTTGATCTGAAAGATTCAAATTTAGTTTTTAATT
GGTTTAAAAAAAATAAACCGGATATCGTAATTTTCGCGGCTGCTAAAGTTGGAGGAATATTTGCAAATAACACATATCCA
GTTGACTTTTTATTAGATAACTTAAAGATTCAAAATAATGTTATTGAAAGTGCTTGGAAAAATAAAGTGAGGAGGTTACT
TTTTCTTGGGAGTAGTTGTGTTTATCCAAAAAATTCAAGTCAACCCATAAATGAAGATGAATTACTAAAAAGTTCTCTTG
AGAAAACGAACGAATGGTATGCATTAGCAAAGATTAGTGGAATTAAATTATGTCAGGCATTAAGAAAACAGTATGGATTT
GATGCAATATCACTTATGCCAACGAATCTCTATGGTAAAGGTGACAATTATCATTCATCTAATAGTCATGTTCTACCAGC
TTTACTTGATAGATTCCATTCACACAAACTTGAGCAAAAAAACTATATTGAATGTTGGGGATCTGGAAATCCAAGGAGAG
AATTTATGCATGTTGATGACTTGGCAGATGCTTCAATTTTCGCACTGGAAAATTGGGATCCCAATAAAAATGACGCACCT
TTAGATCAATCAGGAGAGCCATTAAATTGGCTTAATGTTGGCACAGGAATTGATTTGAGTATAAAAGAGCTTGCCGAGAT
GATTGCTAGTATCACCTCATTCAAAGGGAAAATCATTTGGAACAAAGATAAACCCGATGGGACATTTAGGAAACTTTTAA
ACGTTTCAAAATTAGAAAAATTAGGTTGGAGATCAAAAATATCTTTGGAGGAAGGACTACTAATTACGTATAAAGACTAT
AAAAAAGAATTAAAAGAGAACAAACTTAGAATTAAATAA

Upstream 100 bases:

>100_bases
ATGATAGAATCTGATAAAGAAGAAGCTAGGAAAGACTCTCTATTGAAAAAATCAGGTTTTCAAATAAATAATTCCCAAGA
ATAAAGATGGTTCATATTAG

Downstream 100 bases:

>100_bases
AAACAATTCCAATTTAACAGAGTTGGGAAATCATTATGAGCATTATTTTTAAAAATTTTTTTTGGAATAACTTTTATAAT
AATTTTCCAAATTTAAGTAT

Product: putative fucose synthetase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTLINKEEKIFIAGGSGMVGSAIIRKLNNLGFKHLIFPNSSELDLKDSNLVFNWFKKNKPDIVIFAAAKVGGIFANNTYP
VDFLLDNLKIQNNVIESAWKNKVRRLLFLGSSCVYPKNSSQPINEDELLKSSLEKTNEWYALAKISGIKLCQALRKQYGF
DAISLMPTNLYGKGDNYHSSNSHVLPALLDRFHSHKLEQKNYIECWGSGNPRREFMHVDDLADASIFALENWDPNKNDAP
LDQSGEPLNWLNVGTGIDLSIKELAEMIASITSFKGKIIWNKDKPDGTFRKLLNVSKLEKLGWRSKISLEEGLLITYKDY
KKELKENKLRIK

Sequences:

>Translated_332_residues
MTLINKEEKIFIAGGSGMVGSAIIRKLNNLGFKHLIFPNSSELDLKDSNLVFNWFKKNKPDIVIFAAAKVGGIFANNTYP
VDFLLDNLKIQNNVIESAWKNKVRRLLFLGSSCVYPKNSSQPINEDELLKSSLEKTNEWYALAKISGIKLCQALRKQYGF
DAISLMPTNLYGKGDNYHSSNSHVLPALLDRFHSHKLEQKNYIECWGSGNPRREFMHVDDLADASIFALENWDPNKNDAP
LDQSGEPLNWLNVGTGIDLSIKELAEMIASITSFKGKIIWNKDKPDGTFRKLLNVSKLEKLGWRSKISLEEGLLITYKDY
KKELKENKLRIK
>Mature_331_residues
TLINKEEKIFIAGGSGMVGSAIIRKLNNLGFKHLIFPNSSELDLKDSNLVFNWFKKNKPDIVIFAAAKVGGIFANNTYPV
DFLLDNLKIQNNVIESAWKNKVRRLLFLGSSCVYPKNSSQPINEDELLKSSLEKTNEWYALAKISGIKLCQALRKQYGFD
AISLMPTNLYGKGDNYHSSNSHVLPALLDRFHSHKLEQKNYIECWGSGNPRREFMHVDDLADASIFALENWDPNKNDAPL
DQSGEPLNWLNVGTGIDLSIKELAEMIASITSFKGKIIWNKDKPDGTFRKLLNVSKLEKLGWRSKISLEEGLLITYKDYK
KELKENKLRIK

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=293, Percent_Identity=33.1058020477816, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI7657641, Length=287, Percent_Identity=24.0418118466899, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788365, Length=312, Percent_Identity=51.6025641025641, Blast_Score=336, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17554428, Length=297, Percent_Identity=28.956228956229, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19922778, Length=302, Percent_Identity=29.8013245033113, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 37698; Mature: 37567

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLINKEEKIFIAGGSGMVGSAIIRKLNNLGFKHLIFPNSSELDLKDSNLVFNWFKKNKP
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
DIVIFAAAKVGGIFANNTYPVDFLLDNLKIQNNVIESAWKNKVRRLLFLGSSCVYPKNSS
CEEEEEECCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
QPINEDELLKSSLEKTNEWYALAKISGIKLCQALRKQYGFDAISLMPTNLYGKGDNYHSS
CCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NSHVLPALLDRFHSHKLEQKNYIECWGSGNPRREFMHVDDLADASIFALENWDPNKNDAP
CCEEHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEECCCCCCCEEEEEECCCCCCCCCC
LDQSGEPLNWLNVGTGIDLSIKELAEMIASITSFKGKIIWNKDKPDGTFRKLLNVSKLEK
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
LGWRSKISLEEGLLITYKDYKKELKENKLRIK
HCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLINKEEKIFIAGGSGMVGSAIIRKLNNLGFKHLIFPNSSELDLKDSNLVFNWFKKNKP
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEECCCCC
DIVIFAAAKVGGIFANNTYPVDFLLDNLKIQNNVIESAWKNKVRRLLFLGSSCVYPKNSS
CEEEEEECCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
QPINEDELLKSSLEKTNEWYALAKISGIKLCQALRKQYGFDAISLMPTNLYGKGDNYHSS
CCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NSHVLPALLDRFHSHKLEQKNYIECWGSGNPRREFMHVDDLADASIFALENWDPNKNDAP
CCEEHHHHHHHHHHHCCCCCCEEEEECCCCCHHHEEECCCCCCCEEEEEECCCCCCCCCC
LDQSGEPLNWLNVGTGIDLSIKELAEMIASITSFKGKIIWNKDKPDGTFRKLLNVSKLEK
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
LGWRSKISLEEGLLITYKDYKKELKENKLRIK
HCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]