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The map label for this gene is gmd [H]

Identifier: 123966601

GI number: 123966601

Start: 1201440

End: 1202546

Strand: Direct

Name: gmd [H]

Synonym: P9515_13681

Alternate gene names: 123966601

Gene position: 1201440-1202546 (Clockwise)

Preceding gene: 123966599

Following gene: 123966602

Centisome position: 70.5

GC content: 34.69

Gene sequence:

>1107_bases
ATGAATAAAAAAGCCTTAATTACTGGAGTTACCGGACAAGATGGGAGTTATCTAGTTGAATTTCTTTTAAATAAAAAATA
CGAAGTACATGGAATAAAGAGGAGAAGTAGTAGCTTAAACACGCGAAGGGTAGATCATCTATATCAAGATCCACATGAAA
ATAATCCAAGATTTTTTATGCATTATGGTGATCTAACTGACAGTACAAACTTAATAAGACTTATACAAGATATCTCCCCT
GATGAAATTTATAATTTAGGTGCTCAAAGTCATGTAGCAGTTAGTTTTGAAACTCCCGAATATACTGCTAATTGCGATGC
TTTAGGCACCTTAAGAATATTAGAGGCAGTTCGAGTATTAGGTCTCTCAAAAAAAACAAAAATATATCAAGCCAGCACTA
GTGAATTATATGGTTTGGTTCAGGAAACACCTCAAAACGAAAAAACACCTTTCTATCCTAGAAGTCCATATGGTGTTGCA
AAATTATATGCTTATTGGATTACGATTAATTATCGAGAAGCATATGGAATGTACGCATGTAACGGGATTCTTTTCAACCA
TGAAAGCCCTAGGAGAGGAGAAACATTTATCACGAGAAAAATCACAAGAGGGCTTGCGAGAATAGATGCTGGCCTTGAAA
AACTTCTTTTCTTGGGAAATCTTAATTCAAAAAGGGATTGGGGACACGCAAGAGACTATGTGGAAATGCAATGGCTAATG
CTTCAACAAAAGGAACCAAAAGATTATGTCATATCAACTGGGAGAGCAGAAAGTATAAGAAAATTTGCTGAGATAAGTGC
ATCTTATCTTGGCTGGAGTGATAAAGGAAAACCTGGGATAATTTGGGAAGGAGAAGGTTTAAATGAAGTGGGAAGAAGAG
CTGATACTATGGAAATAGTTATCAAAGTTGACCCCAGATACTTTAGACCAACTGAAGTTGAATTTCTTCTTGGTGAATCA
AAAAAAGCATCTCTAGAATTAGGTTGGACTCCAAACACTTCATTAGAAGAATTAGTAAAAGAAATGATAGAATCTGATAA
AGAAGAAGCTAGGAAAGACTCTCTATTGAAAAAATCAGGTTTTCAAATAAATAATTCCCAAGAATAA

Upstream 100 bases:

>100_bases
ATGAATACAAATCACTTTTATGAAGCTATATAATTAAACCTATATTAAATTCACAATGAAATATGTATTTTGAAAAAGTA
TTAATAAATAAAATAAAATT

Downstream 100 bases:

>100_bases
AGATGGTTCATATTAGATGACACTAATAAATAAGGAAGAAAAAATATTTATAGCTGGGGGAAGTGGAATGGTTGGAAGTG
CCATAATAAGAAAGTTGAAT

Product: gdpmannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNKKALITGVTGQDGSYLVEFLLNKKYEVHGIKRRSSSLNTRRVDHLYQDPHENNPRFFMHYGDLTDSTNLIRLIQDISP
DEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAVRVLGLSKKTKIYQASTSELYGLVQETPQNEKTPFYPRSPYGVA
KLYAYWITINYREAYGMYACNGILFNHESPRRGETFITRKITRGLARIDAGLEKLLFLGNLNSKRDWGHARDYVEMQWLM
LQQKEPKDYVISTGRAESIRKFAEISASYLGWSDKGKPGIIWEGEGLNEVGRRADTMEIVIKVDPRYFRPTEVEFLLGES
KKASLELGWTPNTSLEELVKEMIESDKEEARKDSLLKKSGFQINNSQE

Sequences:

>Translated_368_residues
MNKKALITGVTGQDGSYLVEFLLNKKYEVHGIKRRSSSLNTRRVDHLYQDPHENNPRFFMHYGDLTDSTNLIRLIQDISP
DEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAVRVLGLSKKTKIYQASTSELYGLVQETPQNEKTPFYPRSPYGVA
KLYAYWITINYREAYGMYACNGILFNHESPRRGETFITRKITRGLARIDAGLEKLLFLGNLNSKRDWGHARDYVEMQWLM
LQQKEPKDYVISTGRAESIRKFAEISASYLGWSDKGKPGIIWEGEGLNEVGRRADTMEIVIKVDPRYFRPTEVEFLLGES
KKASLELGWTPNTSLEELVKEMIESDKEEARKDSLLKKSGFQINNSQE
>Mature_368_residues
MNKKALITGVTGQDGSYLVEFLLNKKYEVHGIKRRSSSLNTRRVDHLYQDPHENNPRFFMHYGDLTDSTNLIRLIQDISP
DEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAVRVLGLSKKTKIYQASTSELYGLVQETPQNEKTPFYPRSPYGVA
KLYAYWITINYREAYGMYACNGILFNHESPRRGETFITRKITRGLARIDAGLEKLLFLGNLNSKRDWGHARDYVEMQWLM
LQQKEPKDYVISTGRAESIRKFAEISASYLGWSDKGKPGIIWEGEGLNEVGRRADTMEIVIKVDPRYFRPTEVEFLLGES
KKASLELGWTPNTSLEELVKEMIESDKEEARKDSLLKKSGFQINNSQE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=352, Percent_Identity=58.8068181818182, Blast_Score=437, Evalue=1e-123,
Organism=Escherichia coli, GI1788366, Length=373, Percent_Identity=64.0750670241287, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI48994969, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=346, Percent_Identity=59.2485549132948, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI133901790, Length=346, Percent_Identity=59.2485549132948, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI133901788, Length=346, Percent_Identity=59.2485549132948, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539422, Length=346, Percent_Identity=59.2485549132948, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI133901786, Length=346, Percent_Identity=59.2485549132948, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17507723, Length=346, Percent_Identity=59.2485549132948, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24158427, Length=355, Percent_Identity=57.7464788732394, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 42160; Mature: 42160

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKALITGVTGQDGSYLVEFLLNKKYEVHGIKRRSSSLNTRRVDHLYQDPHENNPRFFM
CCCCEEEEECCCCCHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEEE
HYGDLTDSTNLIRLIQDISPDEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAVRVL
EECCCCCCHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
GLSKKTKIYQASTSELYGLVQETPQNEKTPFYPRSPYGVAKLYAYWITINYREAYGMYAC
CCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEEEEEHHHCCEEEE
NGILFNHESPRRGETFITRKITRGLARIDAGLEKLLFLGNLNSKRDWGHARDYVEMQWLM
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LQQKEPKDYVISTGRAESIRKFAEISASYLGWSDKGKPGIIWEGEGLNEVGRRADTMEIV
HHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHCCCCCEEEEE
IKVDPRYFRPTEVEFLLGESKKASLELGWTPNTSLEELVKEMIESDKEEARKDSLLKKSG
EEECCCCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCC
FQINNSQE
CCCCCCCC
>Mature Secondary Structure
MNKKALITGVTGQDGSYLVEFLLNKKYEVHGIKRRSSSLNTRRVDHLYQDPHENNPRFFM
CCCCEEEEECCCCCHHHHHHHHHCCCEEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEEE
HYGDLTDSTNLIRLIQDISPDEIYNLGAQSHVAVSFETPEYTANCDALGTLRILEAVRVL
EECCCCCCHHHHHHHHHCCHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
GLSKKTKIYQASTSELYGLVQETPQNEKTPFYPRSPYGVAKLYAYWITINYREAYGMYAC
CCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEEEEEEEEHHHCCEEEE
NGILFNHESPRRGETFITRKITRGLARIDAGLEKLLFLGNLNSKRDWGHARDYVEMQWLM
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
LQQKEPKDYVISTGRAESIRKFAEISASYLGWSDKGKPGIIWEGEGLNEVGRRADTMEIV
HHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHCCCCCEEEEE
IKVDPRYFRPTEVEFLLGESKKASLELGWTPNTSLEELVKEMIESDKEEARKDSLLKKSG
EEECCCCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCC
FQINNSQE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]