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The map label for this gene is uppS [H]

Identifier: 123966416

GI number: 123966416

Start: 1040003

End: 1040806

Strand: Direct

Name: uppS [H]

Synonym: P9515_11831

Alternate gene names: 123966416

Gene position: 1040003-1040806 (Clockwise)

Preceding gene: 123966415

Following gene: 123966417

Centisome position: 61.03

GC content: 30.6

Gene sequence:

>804_bases
ATGAGATCGCAAAAAATATCAACTAAAGAAAATTCAAAATTATCTAATGAAATAGATAAACTTCGAGTACCGAAGCACAT
TGCAATAATCATGGATGGGAATGGAAGATGGGCCAGTAAAAAGGGTTTACCCCGATCATTTGGGCACAATAAGGGTGTTA
ATGTTCTCAAGGAAATCATTAAAGTATCTAAAAACTTAGATTGTCAAGTACTTACTGTTTATGCATTTTCAACGGAGAAT
TGGACAAGACCTTCTACAGAGGTTGATTTTCTCATAAATTTGTTTGAAAAAGTTTTGAAAAAAGAAATTACTGAGATTCA
TCAAGAATCAATAAAAATTAAGTTCATTGGAGATTTATCCCCTTTTCCAAAGGCATTAAAATCAATAATAAATAGTTCAG
AAACTCTTACAAAAAATAATAAAAATTTCACATTAAATATCTGTGTTAATTACGGAGGTAGGCAAGAAATAGTGAAAGCC
GCAAGAGAAATAGCAATTAAATCTTTGGCAGGCGAAATAAAACCCAGTGAAATTGATGAACAATTATTTAATTCACAACT
ACTAACTCATGGGATCAAGGATCCTGAATTACTTATACGTACCAGTGGTGAGAAAAGAATAAGTAATTTTCTTTTATGGC
AATTGGCTTACTCTGAAATTTATATAACTGATGTATTATGGCCTGATTTTAATGAAATTGAATTTTTCAAAGCAATTATT
GACTATCAATCAAGGGATAGGCGTTTTGGAGGTATACAATCATTACCAAATAAATCTTGCAAAGATTCTAACTATTCTTC
CTAA

Upstream 100 bases:

>100_bases
AAATCATCTGCAAACAAAAGCACTTTTTCCCAAAATATAAATACGAGTGATAATATTACTATTGAAAACGATTCAAATAA
ATCAGATTAAAGATTAATTC

Downstream 100 bases:

>100_bases
TCAAAAATGATTAATTCAGATAATCAAAAATTTAGCAAAATTAGATTTGACTGGGCAAGGGATGAGATTTTGGAAATATT
AAATTACCCATTAGTAGATT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MRSQKISTKENSKLSNEIDKLRVPKHIAIIMDGNGRWASKKGLPRSFGHNKGVNVLKEIIKVSKNLDCQVLTVYAFSTEN
WTRPSTEVDFLINLFEKVLKKEITEIHQESIKIKFIGDLSPFPKALKSIINSSETLTKNNKNFTLNICVNYGGRQEIVKA
AREIAIKSLAGEIKPSEIDEQLFNSQLLTHGIKDPELLIRTSGEKRISNFLLWQLAYSEIYITDVLWPDFNEIEFFKAII
DYQSRDRRFGGIQSLPNKSCKDSNYSS

Sequences:

>Translated_267_residues
MRSQKISTKENSKLSNEIDKLRVPKHIAIIMDGNGRWASKKGLPRSFGHNKGVNVLKEIIKVSKNLDCQVLTVYAFSTEN
WTRPSTEVDFLINLFEKVLKKEITEIHQESIKIKFIGDLSPFPKALKSIINSSETLTKNNKNFTLNICVNYGGRQEIVKA
AREIAIKSLAGEIKPSEIDEQLFNSQLLTHGIKDPELLIRTSGEKRISNFLLWQLAYSEIYITDVLWPDFNEIEFFKAII
DYQSRDRRFGGIQSLPNKSCKDSNYSS
>Mature_267_residues
MRSQKISTKENSKLSNEIDKLRVPKHIAIIMDGNGRWASKKGLPRSFGHNKGVNVLKEIIKVSKNLDCQVLTVYAFSTEN
WTRPSTEVDFLINLFEKVLKKEITEIHQESIKIKFIGDLSPFPKALKSIINSSETLTKNNKNFTLNICVNYGGRQEIVKA
AREIAIKSLAGEIKPSEIDEQLFNSQLLTHGIKDPELLIRTSGEKRISNFLLWQLAYSEIYITDVLWPDFNEIEFFKAII
DYQSRDRRFGGIQSLPNKSCKDSNYSS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=40.625, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=40.625, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=47.1615720524017, Blast_Score=243, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=35.3982300884956, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=39.63133640553, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=33.4801762114537, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=34.4827586206897, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30528; Mature: 30528

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSQKISTKENSKLSNEIDKLRVPKHIAIIMDGNGRWASKKGLPRSFGHNKGVNVLKEII
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KVSKNLDCQVLTVYAFSTENWTRPSTEVDFLINLFEKVLKKEITEIHQESIKIKFIGDLS
HHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCC
PFPKALKSIINSSETLTKNNKNFTLNICVNYGGRQEIVKAAREIAIKSLAGEIKPSEIDE
HHHHHHHHHHCCCHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
QLFNSQLLTHGIKDPELLIRTSGEKRISNFLLWQLAYSEIYITDVLWPDFNEIEFFKAII
HHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHH
DYQSRDRRFGGIQSLPNKSCKDSNYSS
HHHHCCCCCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRSQKISTKENSKLSNEIDKLRVPKHIAIIMDGNGRWASKKGLPRSFGHNKGVNVLKEII
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHH
KVSKNLDCQVLTVYAFSTENWTRPSTEVDFLINLFEKVLKKEITEIHQESIKIKFIGDLS
HHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCC
PFPKALKSIINSSETLTKNNKNFTLNICVNYGGRQEIVKAAREIAIKSLAGEIKPSEIDE
HHHHHHHHHHCCCHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
QLFNSQLLTHGIKDPELLIRTSGEKRISNFLLWQLAYSEIYITDVLWPDFNEIEFFKAII
HHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHH
DYQSRDRRFGGIQSLPNKSCKDSNYSS
HHHHCCCCCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]