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The map label for this gene is pgi

Identifier: 123966205

GI number: 123966205

Start: 868110

End: 869693

Strand: Reverse

Name: pgi

Synonym: P9515_09721

Alternate gene names: 123966205

Gene position: 869693-868110 (Counterclockwise)

Preceding gene: 123966207

Following gene: 123966203

Centisome position: 51.03

GC content: 29.42

Gene sequence:

>1584_bases
ATGAATAATGATTTTAATTCTTGGGACAAATATTGTGATTACCTCTGGTATGACCAAAAAATAAATATTTGGTTAGATAT
CAGCAAAATTAATTTTTCTTATGATCAAATTTCATCTTTAGAAAATAAATTTATAGGTGTCTTTTCCTCCATAAAGGAAT
TAGAAGCAGGTGCGATTTCAAATATAGATGAGAAAAGACAAGTTGGGCATTATTGGTTAAGAAATCCATCTATAGCTCCA
AATACATTTATAAAGGATGAAATTATTAAAGATATTAGAGATATTTCAGAATTTGGAGATAAGGTTTTAAAGGGTATAAT
TAAAAATAATAAAAATCAAACTTATACTGATGTTTTATGGATAGGTATTGGAGGAAGTGGTCTAGGACCATTACTAATAA
CTGAAGCATTACAAGAAAATTCTGTTGGATTAAATTTTTCATACATTGATAATATTGATCCATTCTTAATAAGTGAGAAA
TTAGATGAATTATCGGACAAATTGCCTACCACATTATTTGTCGTTGTAAGTAAGTCAGGTGGAACACCTGAACCCAAAAT
AGCAATGAATATAATTAAGAGGCATGTTGAAGATAAAAATATATTGTGGAATTCAAATGCAATAGCTATAACAATGAAAA
ATAGTCAACTATATAAAAAAGCAAAATTAGAGAATTGGTTAAAAATCTTTAATTTACCTGATTGGGTTGGCGGAAGAACA
AGTATAACGAGCTCAGTTGGCCTGCTTCCTTTAGCCCTTATTAATCAAGATGTCTCTGAATTTATTAGAGGAGCATCCAT
AATGGATGAGTTAACCCGGATAACTAACATTAAAGATAATCCAGCTGCATTACTTTCTTCGGCTTGGTTTTTTTCTGGAA
ATGGAATAGGGAAAAGAGATATGGTCGTATTACCTTACAGAGACAGGTTACAAGTATTTAGTAAATATCTTCAACAACTA
GTTATGGAATCATTAGGAAAAAAATTCAATAGAAAGGGTAAAATAGTTCATCAAGGAATTTCTGTTTTTGGTAACAAAGG
CTCCACTGATCAACATGCATATGTTCAACAGTTAAGAGATGGAATTGATAATTTCTTTTGTGTTTTCATAGAGTTACTTG
ATATTCCTGATGACAATAAATATTTTGGTTCTGAAAATCCTAAAGAATTTTTATCTGGATTTTTGCAAGGTACAAGATCA
GCATTATCTAACGAAAACAGACAAAGCATAACAATTACCTTAGATAAATTAAATTGTTTAACTCTCGGAGCCTTAATTGC
ATTATTTGAGCGAGCTGTTTCTTTTTACGCAGAATTAGTTGATATAAATGCTTATGATCAACCTGGAGTTGAAGCAGGTA
AAAAAGCAGCAGCAGAAATACTTGAATATCAAAAAAAAGTTACTGAATTATTAAATAATGGAGAAGAATTCTCAATAAAA
AAAATTACTTCTCTTATTGAGAATTCAACATCTGAACCAATATTTTTTATAATACGTCAGATGTGCTTTGGCAATGATGA
TTATCTAATAAAAGGAGATTGGTCAAACCCTATTTCAATAATCATTAAAAAAAATAGTAAATAA

Upstream 100 bases:

>100_bases
TTATTTAAAAATAATATAACTAAATAAATTGAAATGATTAGTATTTACAAGCAATAAACTAGATATAATAAATAAAATCA
GAAAAAGTCAAAAATATAAA

Downstream 100 bases:

>100_bases
TTAAACAACAATATTCATTATTTTACCTTTTACAATTATTATTTTTCTTATGGTTTTTTGATCAATCCATTTTCTTACGT
TAGGTCTTGTTAATGTTTTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNNDFNSWDKYCDYLWYDQKINIWLDISKINFSYDQISSLENKFIGVFSSIKELEAGAISNIDEKRQVGHYWLRNPSIAP
NTFIKDEIIKDIRDISEFGDKVLKGIIKNNKNQTYTDVLWIGIGGSGLGPLLITEALQENSVGLNFSYIDNIDPFLISEK
LDELSDKLPTTLFVVVSKSGGTPEPKIAMNIIKRHVEDKNILWNSNAIAITMKNSQLYKKAKLENWLKIFNLPDWVGGRT
SITSSVGLLPLALINQDVSEFIRGASIMDELTRITNIKDNPAALLSSAWFFSGNGIGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRKGKIVHQGISVFGNKGSTDQHAYVQQLRDGIDNFFCVFIELLDIPDDNKYFGSENPKEFLSGFLQGTRS
ALSNENRQSITITLDKLNCLTLGALIALFERAVSFYAELVDINAYDQPGVEAGKKAAAEILEYQKKVTELLNNGEEFSIK
KITSLIENSTSEPIFFIIRQMCFGNDDYLIKGDWSNPISIIIKKNSK

Sequences:

>Translated_527_residues
MNNDFNSWDKYCDYLWYDQKINIWLDISKINFSYDQISSLENKFIGVFSSIKELEAGAISNIDEKRQVGHYWLRNPSIAP
NTFIKDEIIKDIRDISEFGDKVLKGIIKNNKNQTYTDVLWIGIGGSGLGPLLITEALQENSVGLNFSYIDNIDPFLISEK
LDELSDKLPTTLFVVVSKSGGTPEPKIAMNIIKRHVEDKNILWNSNAIAITMKNSQLYKKAKLENWLKIFNLPDWVGGRT
SITSSVGLLPLALINQDVSEFIRGASIMDELTRITNIKDNPAALLSSAWFFSGNGIGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRKGKIVHQGISVFGNKGSTDQHAYVQQLRDGIDNFFCVFIELLDIPDDNKYFGSENPKEFLSGFLQGTRS
ALSNENRQSITITLDKLNCLTLGALIALFERAVSFYAELVDINAYDQPGVEAGKKAAAEILEYQKKVTELLNNGEEFSIK
KITSLIENSTSEPIFFIIRQMCFGNDDYLIKGDWSNPISIIIKKNSK
>Mature_527_residues
MNNDFNSWDKYCDYLWYDQKINIWLDISKINFSYDQISSLENKFIGVFSSIKELEAGAISNIDEKRQVGHYWLRNPSIAP
NTFIKDEIIKDIRDISEFGDKVLKGIIKNNKNQTYTDVLWIGIGGSGLGPLLITEALQENSVGLNFSYIDNIDPFLISEK
LDELSDKLPTTLFVVVSKSGGTPEPKIAMNIIKRHVEDKNILWNSNAIAITMKNSQLYKKAKLENWLKIFNLPDWVGGRT
SITSSVGLLPLALINQDVSEFIRGASIMDELTRITNIKDNPAALLSSAWFFSGNGIGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRKGKIVHQGISVFGNKGSTDQHAYVQQLRDGIDNFFCVFIELLDIPDDNKYFGSENPKEFLSGFLQGTRS
ALSNENRQSITITLDKLNCLTLGALIALFERAVSFYAELVDINAYDQPGVEAGKKAAAEILEYQKKVTELLNNGEEFSIK
KITSLIENSTSEPIFFIIRQMCFGNDDYLIKGDWSNPISIIIKKNSK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=483, Percent_Identity=29.399585921325, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI296080693, Length=479, Percent_Identity=27.5574112734864, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1790457, Length=481, Percent_Identity=28.6902286902287, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71996708, Length=438, Percent_Identity=29.2237442922374, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71996703, Length=438, Percent_Identity=29.2237442922374, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319673, Length=447, Percent_Identity=29.7539149888143, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24651916, Length=443, Percent_Identity=30.4740406320542, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24651914, Length=443, Percent_Identity=30.4740406320542, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17737445, Length=443, Percent_Identity=30.4740406320542, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PROM5 (A2BWL8)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011286.1
- ProteinModelPortal:   A2BWL8
- SMR:   A2BWL8
- STRING:   A2BWL8
- GeneID:   4719205
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_09721
- eggNOG:   COG0166
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   PMAR167542:P9515ORF_1019-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59582; Mature: 59582

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 323-323 ACT_SITE 352-352 ACT_SITE 454-454

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDFNSWDKYCDYLWYDQKINIWLDISKINFSYDQISSLENKFIGVFSSIKELEAGAIS
CCCCCCCHHHHHHHEEECCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHC
NIDEKRQVGHYWLRNPSIAPNTFIKDEIIKDIRDISEFGDKVLKGIIKNNKNQTYTDVLW
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
IGIGGSGLGPLLITEALQENSVGLNFSYIDNIDPFLISEKLDELSDKLPTTLFVVVSKSG
EEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
GTPEPKIAMNIIKRHVEDKNILWNSNAIAITMKNSQLYKKAKLENWLKIFNLPDWVGGRT
CCCCHHHHHHHHHHHCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCH
SITSSVGLLPLALINQDVSEFIRGASIMDELTRITNIKDNPAALLSSAWFFSGNGIGKRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCC
MVVLPYRDRLQVFSKYLQQLVMESLGKKFNRKGKIVHQGISVFGNKGSTDQHAYVQQLRD
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
GIDNFFCVFIELLDIPDDNKYFGSENPKEFLSGFLQGTRSALSNENRQSITITLDKLNCL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHH
TLGALIALFERAVSFYAELVDINAYDQPGVEAGKKAAAEILEYQKKVTELLNNGEEFSIK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
KITSLIENSTSEPIFFIIRQMCFGNDDYLIKGDWSNPISIIIKKNSK
HHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCC
>Mature Secondary Structure
MNNDFNSWDKYCDYLWYDQKINIWLDISKINFSYDQISSLENKFIGVFSSIKELEAGAIS
CCCCCCCHHHHHHHEEECCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHC
NIDEKRQVGHYWLRNPSIAPNTFIKDEIIKDIRDISEFGDKVLKGIIKNNKNQTYTDVLW
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
IGIGGSGLGPLLITEALQENSVGLNFSYIDNIDPFLISEKLDELSDKLPTTLFVVVSKSG
EEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCC
GTPEPKIAMNIIKRHVEDKNILWNSNAIAITMKNSQLYKKAKLENWLKIFNLPDWVGGRT
CCCCHHHHHHHHHHHCCCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCH
SITSSVGLLPLALINQDVSEFIRGASIMDELTRITNIKDNPAALLSSAWFFSGNGIGKRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCCCCCCC
MVVLPYRDRLQVFSKYLQQLVMESLGKKFNRKGKIVHQGISVFGNKGSTDQHAYVQQLRD
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
GIDNFFCVFIELLDIPDDNKYFGSENPKEFLSGFLQGTRSALSNENRQSITITLDKLNCL
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHH
TLGALIALFERAVSFYAELVDINAYDQPGVEAGKKAAAEILEYQKKVTELLNNGEEFSIK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
KITSLIENSTSEPIFFIIRQMCFGNDDYLIKGDWSNPISIIIKKNSK
HHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA