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The map label for this gene is folE [H]

Identifier: 123965835

GI number: 123965835

Start: 537838

End: 538584

Strand: Direct

Name: folE [H]

Synonym: P9515_06001

Alternate gene names: 123965835

Gene position: 537838-538584 (Clockwise)

Preceding gene: 123965834

Following gene: 123965837

Centisome position: 31.56

GC content: 33.2

Gene sequence:

>747_bases
ATGACCTCTACAGTACCTAACGATAATCTTAAGGAGAATTTAGGCGATCAAATAAGCAATAAATTAGTTTCTGAAATAAT
CAGAAATAGAATTAAGGTTAATAAAAAAAGATTCCATGCTAACGACAACATCTCAGATTTCATAAATCCAGGAGAATTAG
ATATTCTACAAAAGGAGGTGGCCTCAAAAGTTAAGGATTTATTAAAGTCTTTAGTAATTGATATTGATAATGATCATAAC
TCTCAAGAGACTGCTGAAAGAGTCGCAAAAATGTATTTGAAAGAAGTTTTTAAAGGTCGTTATCAAAAAAGACCTGATGT
CACTGACTTCCCTAATGCAAAGAAATTAGATGAGATATACACTCTTGGTCCAATAAGTGTACGCTCTGCTTGTTCTCATC
ATATGGTGCCTATTATTGGTGATTGCTGGATTGGGATTAAGCCTGGAGATAAAGTTATAGGAATTTCAAAATTTTCTAGA
GTTGCTGATTGGGTTTTTTCTAGACCACATATTCAAGAGGAAGCTGTCATGATTCTTGCAGATGAAATTGAACGTTTATG
TGAACCAAAAGGTTTAGCAATTCTTGTTAAAGCTAAACATTATTGCATGTGTTGGAGGGGAGTAAAGGAACCTAATACAA
GTATGATTAATTCCATTGTAAGAGGGGACTTTAGACATGATATAAGCCTAAAACAGGAATTCTTTGAGTTAGTTAAACAA
CAACCAAATGCGTTATCTTGTTATTAG

Upstream 100 bases:

>100_bases
ACACCCTAATGAACATTGAGATGTGATATAGTGTTTAGGCAATTTAACTAAAAGTAGATAAAGTAATTAAGTTTGCAGAC
TATTTTCTGATAACATTTCT

Downstream 100 bases:

>100_bases
ATTAGCGAGAAGTTATTTTTTATAGTTGTTTGATATTAATTATTTAAGAAATAGATTATTTATTTATTTCTCTAATTATA
TTTTTTGTTTTTTCTAAATC

Product: putative GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTSTVPNDNLKENLGDQISNKLVSEIIRNRIKVNKKRFHANDNISDFINPGELDILQKEVASKVKDLLKSLVIDIDNDHN
SQETAERVAKMYLKEVFKGRYQKRPDVTDFPNAKKLDEIYTLGPISVRSACSHHMVPIIGDCWIGIKPGDKVIGISKFSR
VADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAKHYCMCWRGVKEPNTSMINSIVRGDFRHDISLKQEFFELVKQ
QPNALSCY

Sequences:

>Translated_248_residues
MTSTVPNDNLKENLGDQISNKLVSEIIRNRIKVNKKRFHANDNISDFINPGELDILQKEVASKVKDLLKSLVIDIDNDHN
SQETAERVAKMYLKEVFKGRYQKRPDVTDFPNAKKLDEIYTLGPISVRSACSHHMVPIIGDCWIGIKPGDKVIGISKFSR
VADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAKHYCMCWRGVKEPNTSMINSIVRGDFRHDISLKQEFFELVKQ
QPNALSCY
>Mature_247_residues
TSTVPNDNLKENLGDQISNKLVSEIIRNRIKVNKKRFHANDNISDFINPGELDILQKEVASKVKDLLKSLVIDIDNDHNS
QETAERVAKMYLKEVFKGRYQKRPDVTDFPNAKKLDEIYTLGPISVRSACSHHMVPIIGDCWIGIKPGDKVIGISKFSRV
ADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAKHYCMCWRGVKEPNTSMINSIVRGDFRHDISLKQEFFELVKQQ
PNALSCY

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=123, Percent_Identity=34.1463414634146, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4503949, Length=123, Percent_Identity=34.1463414634146, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788476, Length=183, Percent_Identity=30.0546448087432, Blast_Score=107, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=30.8988764044944, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321706, Length=185, Percent_Identity=29.7297297297297, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24656782, Length=157, Percent_Identity=33.7579617834395, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656796, Length=157, Percent_Identity=33.7579617834395, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656791, Length=157, Percent_Identity=33.7579617834395, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 28336; Mature: 28205

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTVPNDNLKENLGDQISNKLVSEIIRNRIKVNKKRFHANDNISDFINPGELDILQKEV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHH
ASKVKDLLKSLVIDIDNDHNSQETAERVAKMYLKEVFKGRYQKRPDVTDFPNAKKLDEIY
HHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TLGPISVRSACSHHMVPIIGDCWIGIKPGDKVIGISKFSRVADWVFSRPHIQEEAVMILA
CCCCHHHHHHHHCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHH
DEIERLCEPKGLAILVKAKHYCMCWRGVKEPNTSMINSIVRGDFRHDISLKQEFFELVKQ
HHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
QPNALSCY
CCCCCCCC
>Mature Secondary Structure 
TSTVPNDNLKENLGDQISNKLVSEIIRNRIKVNKKRFHANDNISDFINPGELDILQKEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHH
ASKVKDLLKSLVIDIDNDHNSQETAERVAKMYLKEVFKGRYQKRPDVTDFPNAKKLDEIY
HHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TLGPISVRSACSHHMVPIIGDCWIGIKPGDKVIGISKFSRVADWVFSRPHIQEEAVMILA
CCCCHHHHHHHHCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHH
DEIERLCEPKGLAILVKAKHYCMCWRGVKEPNTSMINSIVRGDFRHDISLKQEFFELVKQ
HHHHHHCCCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
QPNALSCY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA