Definition Prochlorococcus marinus str. MIT 9515, complete genome.
Accession NC_008817
Length 1,704,176

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The map label for this gene is ephD [H]

Identifier: 123965834

GI number: 123965834

Start: 536920

End: 537684

Strand: Direct

Name: ephD [H]

Synonym: P9515_05991

Alternate gene names: 123965834

Gene position: 536920-537684 (Clockwise)

Preceding gene: 123965833

Following gene: 123965835

Centisome position: 31.51

GC content: 33.59

Gene sequence:

>765_bases
TTGAATCAAGTAGTGTTGAAGAAATTAAGGAAGAATTCACTCAAAAAAAAGAATAAATTGAAATTAGCATTTATTACAGG
AGCATCAAAAGGTATTGGAAGATCTACCGCAATTACTTTCGCAAATGCTGGATGGGATTTAATTTTACTTTCAAGAGATT
TAGAGATGATGGAAACATTAAGAGATGAACTATCAGAAACGAAGTCAAGAATCAATCTTGTGAAGTGTGATTTATCCAAT
TCAAATGAAATAGAAAGTTCTGTCAAAGAATCTATAAAAAAATATGGCTGCCCTTCCGTTCTCATAAATAACGCAGGAGC
TGCTTTTAATGGGAATTTAATAGAAACGTCATTACAAAAATGGCAGGAAATAATTCAAATTAATCTGACAAGTATTTTTC
AACTTTGTAGTTTAATTGTGCCAAAAATGCGGAAAAATGGCGGTTTGATTATTAATGTTAGTAGCCATGCTTCTTATAAT
CCTTTTCCACAATGGGGCCCTTACTGTGTTTCAAAATCTGCTCTTGCAATGTTTACTAAATGTTTAAGAGAGGAGGAAAG
ATCTAATTCAATTAGAGCATGTACAATTACTTTGGGTTCAGTGAATACACCACTATGGGACTCGGAATCAATCAATTCAG
ATTTCGATAGAACAGCGATGCTTTCCTCAACTAAAGTCTCTGATACGATTCTATATATCGCTGAGCAACCTGAATCACAA
TTAATAGAAGATCTAACTCTTATGCCTGCAGGAGGCGCTTTTTAA

Upstream 100 bases:

>100_bases
AAAGCTTCAATTGAGAGGCATCTTAGTGAATTATTGAAAATGAGTAAAGAGGAACTTTTAGAACAAAGATATTCAAAATT
CAGAGTTTTAGGGAAATTTA

Downstream 100 bases:

>100_bases
ATCGAAGACCAGGATTTAAAATGTTCTTAAAGTGATCTTTTATTAGTCTAAATACACCCTAATGAACATTGAGATGTGAT
ATAGTGTTTAGGCAATTTAA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNQVVLKKLRKNSLKKKNKLKLAFITGASKGIGRSTAITFANAGWDLILLSRDLEMMETLRDELSETKSRINLVKCDLSN
SNEIESSVKESIKKYGCPSVLINNAGAAFNGNLIETSLQKWQEIIQINLTSIFQLCSLIVPKMRKNGGLIINVSSHASYN
PFPQWGPYCVSKSALAMFTKCLREEERSNSIRACTITLGSVNTPLWDSESINSDFDRTAMLSSTKVSDTILYIAEQPESQ
LIEDLTLMPAGGAF

Sequences:

>Translated_254_residues
MNQVVLKKLRKNSLKKKNKLKLAFITGASKGIGRSTAITFANAGWDLILLSRDLEMMETLRDELSETKSRINLVKCDLSN
SNEIESSVKESIKKYGCPSVLINNAGAAFNGNLIETSLQKWQEIIQINLTSIFQLCSLIVPKMRKNGGLIINVSSHASYN
PFPQWGPYCVSKSALAMFTKCLREEERSNSIRACTITLGSVNTPLWDSESINSDFDRTAMLSSTKVSDTILYIAEQPESQ
LIEDLTLMPAGGAF
>Mature_254_residues
MNQVVLKKLRKNSLKKKNKLKLAFITGASKGIGRSTAITFANAGWDLILLSRDLEMMETLRDELSETKSRINLVKCDLSN
SNEIESSVKESIKKYGCPSVLINNAGAAFNGNLIETSLQKWQEIIQINLTSIFQLCSLIVPKMRKNGGLIINVSSHASYN
PFPQWGPYCVSKSALAMFTKCLREEERSNSIRACTITLGSVNTPLWDSESINSDFDRTAMLSSTKVSDTILYIAEQPESQ
LIEDLTLMPAGGAF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=28.5024154589372, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4557649, Length=189, Percent_Identity=29.6296296296296, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI31542939, Length=196, Percent_Identity=29.0816326530612, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI59889578, Length=169, Percent_Identity=28.9940828402367, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI32483357, Length=200, Percent_Identity=26, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI142976729, Length=166, Percent_Identity=31.3253012048193, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI224922801, Length=166, Percent_Identity=29.5180722891566, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5031737, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI226371731, Length=179, Percent_Identity=27.9329608938547, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI19923817, Length=139, Percent_Identity=27.3381294964029, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI210032110, Length=166, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=221, Percent_Identity=23.9819004524887, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI126723191, Length=174, Percent_Identity=27.0114942528736, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254986, Length=172, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI7705855, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI7706318, Length=169, Percent_Identity=27.810650887574, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI157739938, Length=185, Percent_Identity=29.1891891891892, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7705925, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI44680136, Length=207, Percent_Identity=26.5700483091787, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI44680133, Length=207, Percent_Identity=26.5700483091787, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI17738292, Length=207, Percent_Identity=26.5700483091787, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=32.6315789473684, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788459, Length=189, Percent_Identity=29.1005291005291, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787905, Length=141, Percent_Identity=31.2056737588652, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=26.6393442622951, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787820, Length=237, Percent_Identity=24.0506329113924, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367175, Length=206, Percent_Identity=27.6699029126214, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=201, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789378, Length=198, Percent_Identity=26.2626262626263, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=26.5625, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790717, Length=194, Percent_Identity=27.319587628866, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787526, Length=193, Percent_Identity=25.9067357512953, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=196, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=30, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=188, Percent_Identity=30.3191489361702, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=203, Percent_Identity=28.0788177339901, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=25.6704980842912, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=191, Percent_Identity=29.8429319371728, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=202, Percent_Identity=29.7029702970297, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=214, Percent_Identity=28.9719626168224, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=26.8, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=196, Percent_Identity=27.5510204081633, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=191, Percent_Identity=29.3193717277487, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=26.1538461538462, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=189, Percent_Identity=28.042328042328, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25152911, Length=243, Percent_Identity=26.3374485596708, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=203, Percent_Identity=28.0788177339901, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=242, Percent_Identity=25.6198347107438, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559552, Length=249, Percent_Identity=27.710843373494, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=200, Percent_Identity=25.5, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=256, Percent_Identity=25, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=256, Percent_Identity=25, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=192, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=189, Percent_Identity=26.4550264550265, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=205, Percent_Identity=29.2682926829268, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=178, Percent_Identity=29.2134831460674, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=25.2873563218391, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557668, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560176, Length=244, Percent_Identity=28.2786885245902, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI212646214, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=208, Percent_Identity=27.4038461538462, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=187, Percent_Identity=24.5989304812834, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=211, Percent_Identity=25.1184834123223, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=218, Percent_Identity=23.8532110091743, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=218, Percent_Identity=23.8532110091743, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323882, Length=246, Percent_Identity=27.2357723577236, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322226, Length=188, Percent_Identity=28.1914893617021, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=194, Percent_Identity=28.8659793814433, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319635, Length=188, Percent_Identity=31.3829787234043, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007236, Length=243, Percent_Identity=27.1604938271605, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644339, Length=195, Percent_Identity=32.8205128205128, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28571526, Length=197, Percent_Identity=30.4568527918782, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=31.2169312169312, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI23397609, Length=183, Percent_Identity=32.2404371584699, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281364494, Length=246, Percent_Identity=29.6747967479675, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571387, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663911, Length=247, Percent_Identity=27.1255060728745, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI116007238, Length=176, Percent_Identity=28.4090909090909, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24641232, Length=243, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641388, Length=245, Percent_Identity=28.9795918367347, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21355319, Length=201, Percent_Identity=29.3532338308458, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24648944, Length=236, Percent_Identity=28.3898305084746, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=190, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24580925, Length=177, Percent_Identity=29.3785310734463, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116007234, Length=247, Percent_Identity=24.6963562753036, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356301, Length=194, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24649181, Length=181, Percent_Identity=26.5193370165746, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24640442, Length=188, Percent_Identity=26.5957446808511, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=199, Percent_Identity=25.6281407035176, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24643142, Length=176, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24584748, Length=199, Percent_Identity=25.1256281407035, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161076933, Length=199, Percent_Identity=25.1256281407035, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357673, Length=202, Percent_Identity=25.7425742574257, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574402, Length=177, Percent_Identity=26.5536723163842, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584744, Length=177, Percent_Identity=26.5536723163842, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584752, Length=175, Percent_Identity=26.2857142857143, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648693, Length=246, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355889, Length=246, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24665243, Length=245, Percent_Identity=27.3469387755102, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221331218, Length=243, Percent_Identity=27.1604938271605, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28121; Mature: 28121

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNQVVLKKLRKNSLKKKNKLKLAFITGASKGIGRSTAITFANAGWDLILLSRDLEMMETL
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHH
RDELSETKSRINLVKCDLSNSNEIESSVKESIKKYGCPSVLINNAGAAFNGNLIETSLQK
HHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHH
WQEIIQINLTSIFQLCSLIVPKMRKNGGLIINVSSHASYNPFPQWGPYCVSKSALAMFTK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
CLREEERSNSIRACTITLGSVNTPLWDSESINSDFDRTAMLSSTKVSDTILYIAEQPESQ
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCHHH
LIEDLTLMPAGGAF
HHHHHHCCCCCCCC
>Mature Secondary Structure
MNQVVLKKLRKNSLKKKNKLKLAFITGASKGIGRSTAITFANAGWDLILLSRDLEMMETL
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEEECCHHHHHHH
RDELSETKSRINLVKCDLSNSNEIESSVKESIKKYGCPSVLINNAGAAFNGNLIETSLQK
HHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHH
WQEIIQINLTSIFQLCSLIVPKMRKNGGLIINVSSHASYNPFPQWGPYCVSKSALAMFTK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
CLREEERSNSIRACTITLGSVNTPLWDSESINSDFDRTAMLSSTKVSDTILYIAEQPESQ
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCHHH
LIEDLTLMPAGGAF
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]