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The map label for this gene is ubiE [H]

Identifier: 123965728

GI number: 123965728

Start: 440706

End: 441407

Strand: Direct

Name: ubiE [H]

Synonym: P9515_04931

Alternate gene names: 123965728

Gene position: 440706-441407 (Clockwise)

Preceding gene: 123965727

Following gene: 123965730

Centisome position: 25.86

GC content: 25.64

Gene sequence:

>702_bases
ATGAGGCATAAAAAAATTAATGAGGTCAAAACTATTTTTAATAATATTTCTTGTAGTTATGACTTTTTAAATAGTTTATT
CAGTTTAGGATTACATAGATTTTGGAAAAATAAATTAGTTTATTTATTAAAACCAATTGATGGAGAAGATTGGGCTGATC
TTTGTTGTGGAACTGGTGATTTATCCTTTCTGATTTTTAAAAAAGTTAGTCCTAATGGAACTGTTACTGGTATTGATAGT
GCAAAAGAAATTTTAAATATTGCAAGGAAAAGGTCCAAATTGATTGGAAATAAATATATATCTTGGGAAATGCAAGACAT
CTTTGAAATAGATGAAAACTTAAAAAATTATGATGGAATTTGTATGTCTTATGGTTTAAGAAATTTGATGAATGTAGAGG
AAGGATTAAAAAAAGTCTTTAATCTTTTAAATAATAGTGGTAGAGCAGGGTTTCTAGACTTTAATCATTCTAAGTTGAAT
TCTTTAGCTGATTTATTTCAAAAAATATATTTAAGATCTATCGTGGTCCCAATTTCAAAATTTTTCCAATTAAGTAAAGA
ATATTCTTATATTGAAAAAAGTATTAAAAGTTTTCCGGAAGGAAATAAACTCATGCTTATCGCGAAAAAAGTTGGTTTTA
AGAGGGTTGAATATAGGACTATTTTTTTCAATCAAATGGGAATATTAATAGTAGAAAAATAA

Upstream 100 bases:

>100_bases
TTACCATTGAAGAAATAAAATCTTTTCTTATTAACAAGAAACTAATAATAAGGCCGAATGAAAAATAGCTTATTATTATT
AATTTTTAAAATGATTAAAT

Downstream 100 bases:

>100_bases
AAAATGATCTTAACCATTTTTTCTCCAACAAAAAGTACATTTCCCCCATCTTGATATTTCACCTTTTGGTGCAGGACTAT
TACATAGTTTGCAAATAACC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRHKKINEVKTIFNNISCSYDFLNSLFSLGLHRFWKNKLVYLLKPIDGEDWADLCCGTGDLSFLIFKKVSPNGTVTGIDS
AKEILNIARKRSKLIGNKYISWEMQDIFEIDENLKNYDGICMSYGLRNLMNVEEGLKKVFNLLNNSGRAGFLDFNHSKLN
SLADLFQKIYLRSIVVPISKFFQLSKEYSYIEKSIKSFPEGNKLMLIAKKVGFKRVEYRTIFFNQMGILIVEK

Sequences:

>Translated_233_residues
MRHKKINEVKTIFNNISCSYDFLNSLFSLGLHRFWKNKLVYLLKPIDGEDWADLCCGTGDLSFLIFKKVSPNGTVTGIDS
AKEILNIARKRSKLIGNKYISWEMQDIFEIDENLKNYDGICMSYGLRNLMNVEEGLKKVFNLLNNSGRAGFLDFNHSKLN
SLADLFQKIYLRSIVVPISKFFQLSKEYSYIEKSIKSFPEGNKLMLIAKKVGFKRVEYRTIFFNQMGILIVEK
>Mature_233_residues
MRHKKINEVKTIFNNISCSYDFLNSLFSLGLHRFWKNKLVYLLKPIDGEDWADLCCGTGDLSFLIFKKVSPNGTVTGIDS
AKEILNIARKRSKLIGNKYISWEMQDIFEIDENLKNYDGICMSYGLRNLMNVEEGLKKVFNLLNNSGRAGFLDFNHSKLN
SLADLFQKIYLRSIVVPISKFFQLSKEYSYIEKSIKSFPEGNKLMLIAKKVGFKRVEYRTIFFNQMGILIVEK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=220, Percent_Identity=25.4545454545455, Blast_Score=91, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17557039, Length=224, Percent_Identity=27.2321428571429, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323526, Length=238, Percent_Identity=25.2100840336134, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641702, Length=240, Percent_Identity=26.25, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 26988; Mature: 26988

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHKKINEVKTIFNNISCSYDFLNSLFSLGLHRFWKNKLVYLLKPIDGEDWADLCCGTGD
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCC
LSFLIFKKVSPNGTVTGIDSAKEILNIARKRSKLIGNKYISWEMQDIFEIDENLKNYDGI
CEEEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCH
CMSYGLRNLMNVEEGLKKVFNLLNNSGRAGFLDFNHSKLNSLADLFQKIYLRSIVVPISK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FFQLSKEYSYIEKSIKSFPEGNKLMLIAKKVGFKRVEYRTIFFNQMGILIVEK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEEEEECCCEEEEEC
>Mature Secondary Structure
MRHKKINEVKTIFNNISCSYDFLNSLFSLGLHRFWKNKLVYLLKPIDGEDWADLCCGTGD
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCCC
LSFLIFKKVSPNGTVTGIDSAKEILNIARKRSKLIGNKYISWEMQDIFEIDENLKNYDGI
CEEEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCH
CMSYGLRNLMNVEEGLKKVFNLLNNSGRAGFLDFNHSKLNSLADLFQKIYLRSIVVPISK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
FFQLSKEYSYIEKSIKSFPEGNKLMLIAKKVGFKRVEYRTIFFNQMGILIVEK
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]