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The map label for this gene is mutM

Identifier: 123965595

GI number: 123965595

Start: 337535

End: 338416

Strand: Reverse

Name: mutM

Synonym: P9515_03601

Alternate gene names: 123965595

Gene position: 338416-337535 (Counterclockwise)

Preceding gene: 123965596

Following gene: 123965594

Centisome position: 19.86

GC content: 31.41

Gene sequence:

>882_bases
TTGCCTGAGTTACCTGAAGTTGAAACTGTTAGAAAAGGTTTAGAGCAAAAACTTAAGAATTTTATTATCAAAAGAGTTGA
AATCTGTAGAGAATCAACTGTTGCTTATCCCATCGATAAACAAGACTTTGTAAAAGGTCTTCAGAACTCACTTATAAATA
AGTGGGATAGAAGAGGAAAATATTTGATCGCGAAACTAAAGAAAGCTGATAGAAATCACACATATATCGAAAATGAAATG
TCATTAAAAAACAATGGTAGCCTTGTGGTTCACCTAAGAATGACTGGTTACTTTACGTTTAATAAAAATCCTACTAGCCC
TTGCAAACATACAAGAATAAGGCTTTTTGATAACAACAATAATGAACTCAGATATATTGATGTAAGAAGTTTTGGACAAA
TGTGGTGGGTTAGAGAGGGATTATCACCAAAAAATATTATTAAAGGATTAGGAGCATTAGGACCTGAGCCATTTTCTGAA
AAATTTAATATCAGTTATCTTACAAAAATAATTTTAAACAAAACAAGATCCATAAAATCTATTTTATTAGATCAAACAAT
CGTAGCTGGAATTGGAAACATATATGCAGATGAAAGTCTTTATTCCGCTGGGATATCCCCTTTTAGAGAGGCTAGAACAA
TTGAAAAACATGAACTAATAAAACTTAGGATAGCAATAATCGAAGTTTTAAAAAAAAGTATTGGTGCAGGCGGAACAACT
TTTAGCGACTTTAGAGACTTAGAAGGAGAAAATGGTAATTTTGGATTACAAACTAATGTCTATAGAAGAACTGGTAAGAA
GTGTCATGCATGCAAAAATTTGATTGAAAGACAAAAAATTTCAGGAAGAAGTACACATTGGTGTCGTAAATGTCAGAAAT
AA

Upstream 100 bases:

>100_bases
GTTAAATTTGATAGAGTTAATTTCTATGGAATAAGTGGAACTGACGGTGGAAACGTGACAAATAACTTTGCTGAAGTTGA
ATTAGAAAAAATTTAAAAAT

Downstream 100 bases:

>100_bases
AAAAGGGCTTACTTTAAAAAAGTAAACCCTTTAAAATATTTTTACCTGGCATTGAGCTATTTTCTCAAGGGGCTACCCCC
TAAATATTTTCGCCGCTGAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPELPEVETVRKGLEQKLKNFIIKRVEICRESTVAYPIDKQDFVKGLQNSLINKWDRRGKYLIAKLKKADRNHTYIENEM
SLKNNGSLVVHLRMTGYFTFNKNPTSPCKHTRIRLFDNNNNELRYIDVRSFGQMWWVREGLSPKNIIKGLGALGPEPFSE
KFNISYLTKIILNKTRSIKSILLDQTIVAGIGNIYADESLYSAGISPFREARTIEKHELIKLRIAIIEVLKKSIGAGGTT
FSDFRDLEGENGNFGLQTNVYRRTGKKCHACKNLIERQKISGRSTHWCRKCQK

Sequences:

>Translated_293_residues
MPELPEVETVRKGLEQKLKNFIIKRVEICRESTVAYPIDKQDFVKGLQNSLINKWDRRGKYLIAKLKKADRNHTYIENEM
SLKNNGSLVVHLRMTGYFTFNKNPTSPCKHTRIRLFDNNNNELRYIDVRSFGQMWWVREGLSPKNIIKGLGALGPEPFSE
KFNISYLTKIILNKTRSIKSILLDQTIVAGIGNIYADESLYSAGISPFREARTIEKHELIKLRIAIIEVLKKSIGAGGTT
FSDFRDLEGENGNFGLQTNVYRRTGKKCHACKNLIERQKISGRSTHWCRKCQK
>Mature_292_residues
PELPEVETVRKGLEQKLKNFIIKRVEICRESTVAYPIDKQDFVKGLQNSLINKWDRRGKYLIAKLKKADRNHTYIENEMS
LKNNGSLVVHLRMTGYFTFNKNPTSPCKHTRIRLFDNNNNELRYIDVRSFGQMWWVREGLSPKNIIKGLGALGPEPFSEK
FNISYLTKIILNKTRSIKSILLDQTIVAGIGNIYADESLYSAGISPFREARTIEKHELIKLRIAIIEVLKKSIGAGGTTF
SDFRDLEGENGNFGLQTNVYRRTGKKCHACKNLIERQKISGRSTHWCRKCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=293, Percent_Identity=36.518771331058, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1786932, Length=305, Percent_Identity=23.6065573770492, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PROM5 (A2BUV8)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010676.1
- ProteinModelPortal:   A2BUV8
- SMR:   A2BUV8
- STRING:   A2BUV8
- GeneID:   4719676
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_03601
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK13945
- BioCyc:   PMAR167542:P9515ORF_0384-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 33740; Mature: 33608

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 283-283 BINDING 110-110 BINDING 129-129 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRKGLEQKLKNFIIKRVEICRESTVAYPIDKQDFVKGLQNSLINKWDRRGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
YLIAKLKKADRNHTYIENEMSLKNNGSLVVHLRMTGYFTFNKNPTSPCKHTRIRLFDNNN
HHHHHHHHCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCEEEEEECCC
NELRYIDVRSFGQMWWVREGLSPKNIIKGLGALGPEPFSEKFNISYLTKIILNKTRSIKS
CEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ILLDQTIVAGIGNIYADESLYSAGISPFREARTIEKHELIKLRIAIIEVLKKSIGAGGTT
HHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSDFRDLEGENGNFGLQTNVYRRTGKKCHACKNLIERQKISGRSTHWCRKCQK
HHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
PELPEVETVRKGLEQKLKNFIIKRVEICRESTVAYPIDKQDFVKGLQNSLINKWDRRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
YLIAKLKKADRNHTYIENEMSLKNNGSLVVHLRMTGYFTFNKNPTSPCKHTRIRLFDNNN
HHHHHHHHCCCCCCEECCCCCCCCCCCEEEEEEEEEEEEECCCCCCCCCCCEEEEEECCC
NELRYIDVRSFGQMWWVREGLSPKNIIKGLGALGPEPFSEKFNISYLTKIILNKTRSIKS
CEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ILLDQTIVAGIGNIYADESLYSAGISPFREARTIEKHELIKLRIAIIEVLKKSIGAGGTT
HHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSDFRDLEGENGNFGLQTNVYRRTGKKCHACKNLIERQKISGRSTHWCRKCQK
HHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA