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The map label for this gene is purE [H]

Identifier: 123965431

GI number: 123965431

Start: 179114

End: 179605

Strand: Reverse

Name: purE [H]

Synonym: P9515_01961

Alternate gene names: 123965431

Gene position: 179605-179114 (Counterclockwise)

Preceding gene: 123965433

Following gene: 123965428

Centisome position: 10.54

GC content: 35.16

Gene sequence:

>492_bases
ATGGGAAGTGATTCAGATCTAAAAACTTTGAAACCTTCAGTTGATATATTGCATGAATTTGGAATAGAAACAGAAGTTTG
TATACTTTCAGCACATCGAACCCCAATTGAAATGATGGAATATGCAAAAAAGGCAGAATCAAAAAATATAAAGGTTATTG
TAGCTGGAGCTGGTGGGGCTGCTCACTTGCCTGGGATGTTAGCTTCACTAACATGTATTCCCGTTATAGGGGTGCCCGTA
GAAAGTAAAACTCTGAAAGGAATCGACTCCCTATTATCAATTGTTCAAATGCCTGCAGGAATTCCAGTAGCAACAGTAGC
CATAAACGGAGCAAAAAATGCTGGGCTTTTAGCAATTCAAATCCTTTGTTTATTTGACGAAGGTTTAAGGATAAAAATGA
AAAAATTTAGAGATAATCTGCATGCACAAGTAAGAACTAAAAACAGTAAATTATTTACTTTAGGGACTGATAATTATCTA
AAAACTTACTAA

Upstream 100 bases:

>100_bases
TAACTAGCGCGCAGGTAATTGCACGTCATTATAAGAAAAGAATTGATTTGTTATTTTGTCAGACTTGAATTCCAGCAATA
TTTCTAAAGTTGCGGTAGTA

Downstream 100 bases:

>100_bases
AAAATTTTTATAAATTAAACATTTGCAAGTAAATTCTTTTCTCTAAGATAATTTATAACTGTTTCAACAGAATCATTTAA
ATCTAAAGAACCTGTATCAA

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MGSDSDLKTLKPSVDILHEFGIETEVCILSAHRTPIEMMEYAKKAESKNIKVIVAGAGGAAHLPGMLASLTCIPVIGVPV
ESKTLKGIDSLLSIVQMPAGIPVATVAINGAKNAGLLAIQILCLFDEGLRIKMKKFRDNLHAQVRTKNSKLFTLGTDNYL
KTY

Sequences:

>Translated_163_residues
MGSDSDLKTLKPSVDILHEFGIETEVCILSAHRTPIEMMEYAKKAESKNIKVIVAGAGGAAHLPGMLASLTCIPVIGVPV
ESKTLKGIDSLLSIVQMPAGIPVATVAINGAKNAGLLAIQILCLFDEGLRIKMKKFRDNLHAQVRTKNSKLFTLGTDNYL
KTY
>Mature_162_residues
GSDSDLKTLKPSVDILHEFGIETEVCILSAHRTPIEMMEYAKKAESKNIKVIVAGAGGAAHLPGMLASLTCIPVIGVPVE
SKTLKGIDSLLSIVQMPAGIPVATVAINGAKNAGLLAIQILCLFDEGLRIKMKKFRDNLHAQVRTKNSKLFTLGTDNYLK
TY

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=106, Percent_Identity=52.8301886792453, Blast_Score=120, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=162, Percent_Identity=52.4691358024691, Blast_Score=168, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17504; Mature: 17373

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDSDLKTLKPSVDILHEFGIETEVCILSAHRTPIEMMEYAKKAESKNIKVIVAGAGGA
CCCCCCCHHCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCC
AHLPGMLASLTCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGAKNAGLLAIQ
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEE
ILCLFDEGLRIKMKKFRDNLHAQVRTKNSKLFTLGTDNYLKTY
EEEHHCCCCEEEHHHHHCCCEEEEEECCCEEEEECCCCCEECC
>Mature Secondary Structure 
GSDSDLKTLKPSVDILHEFGIETEVCILSAHRTPIEMMEYAKKAESKNIKVIVAGAGGA
CCCCCCHHCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCC
AHLPGMLASLTCIPVIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGAKNAGLLAIQ
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEE
ILCLFDEGLRIKMKKFRDNLHAQVRTKNSKLFTLGTDNYLKTY
EEEHHCCCCEEEHHHHHCCCEEEEEECCCEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]