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The map label for this gene is sucD [H]

Identifier: 121999018

GI number: 121999018

Start: 2454182

End: 2455054

Strand: Reverse

Name: sucD [H]

Synonym: Hhal_2239

Alternate gene names: 121999018

Gene position: 2455054-2454182 (Counterclockwise)

Preceding gene: 121999019

Following gene: 121999017

Centisome position: 91.66

GC content: 71.02

Gene sequence:

>873_bases
ATGAGCATTCTCGTCGACCAGAGCACCCGGGTGCTCGTGCAGGGGTTCACCGGCAAGCAGGGGACCTTCCACGCGGAGCA
GGCCATCGCCTACGGCACACAGGTGGTCGGCGGCGTGACCCCGGGGCGGGGCGGCGGCACCCACCTGGATCGCCCGCTGT
TCAATACCGTCCGCGAGGCGGTCGCAGCGACCGGCGCCGACGCCTCGGTGATCTACGTCCCGGCCCCCTTCGCCGCCGAC
GCCATCCTCGAGGCCGCCGACGCCGGGATCCGGGTGATCGCCTGCATCACCGAGGGCATCCCGGTGCTGGACATGCTGCA
CGTCAAGGAGGCCCTGCGGGGCGAAGACGTGGCGCTGATCGGGCCCAACTGCCCCGGGGTCATCACCCCGGATGCGTGCA
AGATCGGCATCATGCCCGGGCACATCCACCTGCCCGGGCGGATCGGCATCGTCTCCCGCTCGGGGACCCTGACCTACGAG
GCGGTCAAACAGACCACGGACATCGGCCTGGGGCAGTCCACCTGTGTCGGCATCGGTGGCGACCCGATCCAGGGGATGTC
GTTCGTCGACTGCCTGGAGCAGTTCGAGGCCGACCCGCACACCGACGGGGTGGTCATGGTCGGTGAGATCGGCGGCAGCG
CCGAGGAGGAGGCCGCCACGTTCATCCGCGACCACATGAGCAAACCGGTGGTCGCCTACATCGCCGGGGTGACCGCGCCG
CCGGGCAAGCGCATGGGTCACGCCGGGGCCATCATCTCCGGCGGCAAGGGGACGGCGGATGACAAGTTCGCCGCCCTGGA
GGCGGCCGGGGTGGCCACCGTGCGCTCGCCGACCGAGATCGGCGAGCGCATCCGGCGGCTGGTGGCGGGCTGA

Upstream 100 bases:

>100_bases
CTCGACCTCATCCCCGCCGACGACTTGGCGGATGCCGCCGCCAAGATTGTCGATATCGCCGGTCAGGTGGCCTGAGCCCC
AGGCAAGAGAGGAGCAGAAC

Downstream 100 bases:

>100_bases
GGCAGACCATGCGCATCGTCGTCGCTCAGCTGCCCTTTCCCGTCGGTGCCTTGGATGACAACGCCCGGCGGATCATCGAT
GCCATCGGCCGGGCGCGGGA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSILVDQSTRVLVQGFTGKQGTFHAEQAIAYGTQVVGGVTPGRGGGTHLDRPLFNTVREAVAATGADASVIYVPAPFAAD
AILEAADAGIRVIACITEGIPVLDMLHVKEALRGEDVALIGPNCPGVITPDACKIGIMPGHIHLPGRIGIVSRSGTLTYE
AVKQTTDIGLGQSTCVGIGGDPIQGMSFVDCLEQFEADPHTDGVVMVGEIGGSAEEEAATFIRDHMSKPVVAYIAGVTAP
PGKRMGHAGAIISGGKGTADDKFAALEAAGVATVRSPTEIGERIRRLVAG

Sequences:

>Translated_290_residues
MSILVDQSTRVLVQGFTGKQGTFHAEQAIAYGTQVVGGVTPGRGGGTHLDRPLFNTVREAVAATGADASVIYVPAPFAAD
AILEAADAGIRVIACITEGIPVLDMLHVKEALRGEDVALIGPNCPGVITPDACKIGIMPGHIHLPGRIGIVSRSGTLTYE
AVKQTTDIGLGQSTCVGIGGDPIQGMSFVDCLEQFEADPHTDGVVMVGEIGGSAEEEAATFIRDHMSKPVVAYIAGVTAP
PGKRMGHAGAIISGGKGTADDKFAALEAAGVATVRSPTEIGERIRRLVAG
>Mature_289_residues
SILVDQSTRVLVQGFTGKQGTFHAEQAIAYGTQVVGGVTPGRGGGTHLDRPLFNTVREAVAATGADASVIYVPAPFAADA
ILEAADAGIRVIACITEGIPVLDMLHVKEALRGEDVALIGPNCPGVITPDACKIGIMPGHIHLPGRIGIVSRSGTLTYEA
VKQTTDIGLGQSTCVGIGGDPIQGMSFVDCLEQFEADPHTDGVVMVGEIGGSAEEEAATFIRDHMSKPVVAYIAGVTAPP
GKRMGHAGAIISGGKGTADDKFAALEAAGVATVRSPTEIGERIRRLVAG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=64.0138408304498, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI38569421, Length=252, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI38569423, Length=252, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=74.3055555555556, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=61.4035087719298, Blast_Score=335, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17553126, Length=294, Percent_Identity=58.5034013605442, Blast_Score=325, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17551266, Length=250, Percent_Identity=30, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17557344, Length=250, Percent_Identity=29.6, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=50.6849315068493, Blast_Score=274, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21356559, Length=288, Percent_Identity=56.9444444444444, Blast_Score=337, Evalue=4e-93,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=59.6551724137931, Blast_Score=318, Evalue=2e-87,
Organism=Drosophila melanogaster, GI281363477, Length=252, Percent_Identity=29.7619047619048, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363475, Length=252, Percent_Identity=29.7619047619048, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363473, Length=252, Percent_Identity=29.7619047619048, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29715; Mature: 29584

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVDQSTRVLVQGFTGKQGTFHAEQAIAYGTQVVGGVTPGRGGGTHLDRPLFNTVREA
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHH
VAATGADASVIYVPAPFAADAILEAADAGIRVIACITEGIPVLDMLHVKEALRGEDVALI
HHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPDACKIGIMPGHIHLPGRIGIVSRSGTLTYEAVKQTTDIGLGQSTCVGIGG
CCCCCCCCCCCCEEEEECCCEEECCCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIQGMSFVDCLEQFEADPHTDGVVMVGEIGGSAEEEAATFIRDHMSKPVVAYIAGVTAP
CCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCC
PGKRMGHAGAIISGGKGTADDKFAALEAAGVATVRSPTEIGERIRRLVAG
CCCCCCCCCEEEECCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILVDQSTRVLVQGFTGKQGTFHAEQAIAYGTQVVGGVTPGRGGGTHLDRPLFNTVREA
EEEECCCCEEEEEECCCCCCCCHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHH
VAATGADASVIYVPAPFAADAILEAADAGIRVIACITEGIPVLDMLHVKEALRGEDVALI
HHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPDACKIGIMPGHIHLPGRIGIVSRSGTLTYEAVKQTTDIGLGQSTCVGIGG
CCCCCCCCCCCCEEEEECCCEEECCCEEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIQGMSFVDCLEQFEADPHTDGVVMVGEIGGSAEEEAATFIRDHMSKPVVAYIAGVTAP
CCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCC
PGKRMGHAGAIISGGKGTADDKFAALEAAGVATVRSPTEIGERIRRLVAG
CCCCCCCCCEEEECCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]