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The map label for this gene is holA [H]

Identifier: 121998922

GI number: 121998922

Start: 2343767

End: 2344771

Strand: Reverse

Name: holA [H]

Synonym: Hhal_2143

Alternate gene names: 121998922

Gene position: 2344771-2343767 (Counterclockwise)

Preceding gene: 121998923

Following gene: 121998921

Centisome position: 87.54

GC content: 74.53

Gene sequence:

>1005_bases
ATGGCCGAGCGGCCGGAGACTCTCCACCGCCAGCTGGAGCGCGGGCCGCTGCCCCGAGTCTGTTTCATCGCCGGCGAGGA
GCCGCTGCTCCAGCGTGAGGCCACCGACGCCGTGCGTCGGGCGGCGCGGGAGGCCGGGCACTCCGAGCGCGAGGTGCTCG
ATGTCGATGCCGGCTTCGACTGGGGGTGGCTCACCGAGGCCGCCAGCAGTCTGTCGCTATTCGGTGATCGTCGCCTGCTG
GAGGTGCGCATGCCCGGCGGCAAGCCCGGGCGCGACGGGGCCGAGGCCCTCAAGGCCTACTGCCAGGACCCCCCGGAGGA
TACCGTCCTGCTGTTGACCAGCGGGCGCCTGGAGCGTTCCGCCCGTGAGTCGGCCTGGGCGCGGGCGCTGGCCGAGGCCG
GGATCTTCGTCTACTGCTGGCCGGTGCCGGGGCGCGACATGCCGCGCTGGGTAGCCGAGCGGCTACGCCGCGCCGGTCTG
CAGGCGGATCCGGAGGCAGCGGCGCTGATCGCCGAGCGCTCCGAGGGGAATCTGCTGGCCGCCGATCAGGCGGTGGAGAA
GCTACGCCTGCTGGTTGGCAGCGGCACCGCCGTGGATGTCGAGACGGCCGCCGGGGCGCTGGCCGACAGCGCCCGGTACA
CCGTGGACGATCTGGCCGACGCTGCCCTGGACGCGGAGTGGACGCGGGCGCTGCGTGTCCTCGCTACGCTCCGGGAGGAG
GGCGTGCAGCCGCCGCTGATCCTCTGGGCCCTGGCCCGGGATATCCGGGTGGCGGCGCGGCTGGCGGCCGGCGCCGATGA
GGGGGTGCTGCAGCGCGAGCGGATCTGGAAGCGGCGGGTCGGGCGGCTGCGCCAAGCGGCCCGCCGGCATCCGGCGGGGG
CCTGGCGGCAGCTGCTGCAGCGCTGCCACCGTGTGGATCGGGCCATCAAGGGCCTGCCGCCCGGTGACCCCTGGGAGCAG
CTGCGGGCCCTGGTCTCTCGTCTGGCCCGCGCCATGGCAAAATAG

Upstream 100 bases:

>100_bases
GTGGCGCCGATGAGCGTCGTGCCCGCGAGGCGGAGCTGGAGGAGGAGCTGCGCGCCGACGCCGTGCGCCTGTTGATGCTG
CGCCTGCAGGCCCTGCGCTG

Downstream 100 bases:

>100_bases
CGCCAATCGGTACACCATATCCCCGATCGAGCCCATTTGAGCAGACCTGATGAGTGCAGAGCATTCGAGCGACATCGCCG
AGACCATTCGCCGGATCGGG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAERPETLHRQLERGPLPRVCFIAGEEPLLQREATDAVRRAAREAGHSEREVLDVDAGFDWGWLTEAASSLSLFGDRRLL
EVRMPGGKPGRDGAEALKAYCQDPPEDTVLLLTSGRLERSARESAWARALAEAGIFVYCWPVPGRDMPRWVAERLRRAGL
QADPEAAALIAERSEGNLLAADQAVEKLRLLVGSGTAVDVETAAGALADSARYTVDDLADAALDAEWTRALRVLATLREE
GVQPPLILWALARDIRVAARLAAGADEGVLQRERIWKRRVGRLRQAARRHPAGAWRQLLQRCHRVDRAIKGLPPGDPWEQ
LRALVSRLARAMAK

Sequences:

>Translated_334_residues
MAERPETLHRQLERGPLPRVCFIAGEEPLLQREATDAVRRAAREAGHSEREVLDVDAGFDWGWLTEAASSLSLFGDRRLL
EVRMPGGKPGRDGAEALKAYCQDPPEDTVLLLTSGRLERSARESAWARALAEAGIFVYCWPVPGRDMPRWVAERLRRAGL
QADPEAAALIAERSEGNLLAADQAVEKLRLLVGSGTAVDVETAAGALADSARYTVDDLADAALDAEWTRALRVLATLREE
GVQPPLILWALARDIRVAARLAAGADEGVLQRERIWKRRVGRLRQAARRHPAGAWRQLLQRCHRVDRAIKGLPPGDPWEQ
LRALVSRLARAMAK
>Mature_333_residues
AERPETLHRQLERGPLPRVCFIAGEEPLLQREATDAVRRAAREAGHSEREVLDVDAGFDWGWLTEAASSLSLFGDRRLLE
VRMPGGKPGRDGAEALKAYCQDPPEDTVLLLTSGRLERSARESAWARALAEAGIFVYCWPVPGRDMPRWVAERLRRAGLQ
ADPEAAALIAERSEGNLLAADQAVEKLRLLVGSGTAVDVETAAGALADSARYTVDDLADAALDAEWTRALRVLATLREEG
VQPPLILWALARDIRVAARLAAGADEGVLQRERIWKRRVGRLRQAARRHPAGAWRQLLQRCHRVDRAIKGLPPGDPWEQL
RALVSRLARAMAK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=297, Percent_Identity=29.2929292929293, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36889; Mature: 36757

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERPETLHRQLERGPLPRVCFIAGEEPLLQREATDAVRRAAREAGHSEREVLDVDAGFD
CCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
WGWLTEAASSLSLFGDRRLLEVRMPGGKPGRDGAEALKAYCQDPPEDTVLLLTSGRLERS
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHH
ARESAWARALAEAGIFVYCWPVPGRDMPRWVAERLRRAGLQADPEAAALIAERSEGNLLA
HHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEH
ADQAVEKLRLLVGSGTAVDVETAAGALADSARYTVDDLADAALDAEWTRALRVLATLREE
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GVQPPLILWALARDIRVAARLAAGADEGVLQRERIWKRRVGRLRQAARRHPAGAWRQLLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RCHRVDRAIKGLPPGDPWEQLRALVSRLARAMAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AERPETLHRQLERGPLPRVCFIAGEEPLLQREATDAVRRAAREAGHSEREVLDVDAGFD
CCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCC
WGWLTEAASSLSLFGDRRLLEVRMPGGKPGRDGAEALKAYCQDPPEDTVLLLTSGRLERS
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHH
ARESAWARALAEAGIFVYCWPVPGRDMPRWVAERLRRAGLQADPEAAALIAERSEGNLLA
HHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEH
ADQAVEKLRLLVGSGTAVDVETAAGALADSARYTVDDLADAALDAEWTRALRVLATLREE
HHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GVQPPLILWALARDIRVAARLAAGADEGVLQRERIWKRRVGRLRQAARRHPAGAWRQLLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RCHRVDRAIKGLPPGDPWEQLRALVSRLARAMAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]