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The map label for this gene is proA

Identifier: 121998921

GI number: 121998921

Start: 2342443

End: 2343717

Strand: Reverse

Name: proA

Synonym: Hhal_2142

Alternate gene names: 121998921

Gene position: 2343717-2342443 (Counterclockwise)

Preceding gene: 121998922

Following gene: 121998920

Centisome position: 87.5

GC content: 71.14

Gene sequence:

>1275_bases
ATGAGTGCAGAGCATTCGAGCGACATCGCCGAGACCATTCGCCGGATCGGGCAGCAGGCCCGCGCCGCCGGGCGCGCCCT
GGCCCGCTCCGGGACCGGTGCGCGCAACGACGCCCTGGCCGCCATCGCCGCCCGTATCGAGGCCGGCTCCGAGGCCATCG
CCGCGGCCAACGCGGCGGACCTGGAGGCCGCCCGCGAGGCCGGGCTCGACCCGGCCCTGATCGATCGCATGGAGCTCACT
CCGGGCCGCATCCAGGCCATGGCCGACGGGCTGCGCGAGATCGCGGCGCTGCCGGATCCGGTGGGTGCGGTGCGCGAGCT
GGCGTCACGGCCCTCGGGGATCCAGGTCGGGCGGATGCGCATGCCCATCGGGGTGATCGGCATCATCTACGAGTCGCGCC
CCAACGTCACCGCCGATGCCGCCGGGCTGTGCATCAAATCCGGCAACGCCACGATCCTGCGCGGCGGCTCCGAGGCGATC
CGCTCCAACCGGGCCATCGCCGAGCAGATTCGCGCCGGGCTAGAGGACGCTGGGTTGCCGGGGGACGGTGTCCAGGTGGT
CGGGACCACCGACCGGGATGCTGTCGGCGCCCTGATCCAGATGCCTGAGTCGGTGGACGTGATCGTCCCCCGCGGCGGCA
AGGGCCTGGTCGAGCGCATCGCCCGCGAGGCGCGGGTGCCGGTGATCAAGCACCTCGACGGTGTCTGCCACGTCTACATC
GACGAGGCCGCCGATACCGAGAAAGCGGTGGCCATTGCCGTCAACGCCAAGACCCAGCGGCTGGGGACCTGCAACACCAT
GGAGACACTGCTGGTGGCCGAGGCGGCCGCCGAGCGGGTGCTGCCGGAGGTTGGACGTCAGCTGCGCGATGCCGGGATCG
AGGTGCGCGGCTGCGAGCGCACACGCGCCCTGATCGACGAGGCGGTGCCCGCTACCGAAGAAGACTGGACCACCGAGTAT
CTCGGGCCCACCCTTGCGGTACGTGTGGTGGCCGGGTTCGACGACGCCGTGGCGCACATCGAGCGCTACAGCTCCGGGCA
CACCGAGGCCATCGTCACCGAGAGCTATCCGCTGGCGCAGCGCTTCCTGCGCGAGGTGGACTCCAGTTCGGTGATGGTCA
ACGCCTCGACCCGCTTCGCCGACGGTCAGGAGTACGGCCTCGGCGCCGAGATCGGGATCAGCACCGACAAGCTCCACGCC
CGGGGCCCGGTGGGGCTGGAGGGGCTGACCACCGAGAAGTGGATCGTCCTCGGTGACGGTCACGTCCGCAGCTGA

Upstream 100 bases:

>100_bases
GAGCAGCTGCGGGCCCTGGTCTCTCGTCTGGCCCGCGCCATGGCAAAATAGCGCCAATCGGTACACCATATCCCCGATCG
AGCCCATTTGAGCAGACCTG

Downstream 100 bases:

>100_bases
CGGCGAGGTGAGCGGACGCGTGAGACAACCGCTGCGTACTATTGGCCTGCTCGGTGGCACGTTCGATCCCATCCACTACG
GCCACCTGCGCCCGGCCGAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSAEHSSDIAETIRRIGQQARAAGRALARSGTGARNDALAAIAARIEAGSEAIAAANAADLEAAREAGLDPALIDRMELT
PGRIQAMADGLREIAALPDPVGAVRELASRPSGIQVGRMRMPIGVIGIIYESRPNVTADAAGLCIKSGNATILRGGSEAI
RSNRAIAEQIRAGLEDAGLPGDGVQVVGTTDRDAVGALIQMPESVDVIVPRGGKGLVERIAREARVPVIKHLDGVCHVYI
DEAADTEKAVAIAVNAKTQRLGTCNTMETLLVAEAAAERVLPEVGRQLRDAGIEVRGCERTRALIDEAVPATEEDWTTEY
LGPTLAVRVVAGFDDAVAHIERYSSGHTEAIVTESYPLAQRFLREVDSSSVMVNASTRFADGQEYGLGAEIGISTDKLHA
RGPVGLEGLTTEKWIVLGDGHVRS

Sequences:

>Translated_424_residues
MSAEHSSDIAETIRRIGQQARAAGRALARSGTGARNDALAAIAARIEAGSEAIAAANAADLEAAREAGLDPALIDRMELT
PGRIQAMADGLREIAALPDPVGAVRELASRPSGIQVGRMRMPIGVIGIIYESRPNVTADAAGLCIKSGNATILRGGSEAI
RSNRAIAEQIRAGLEDAGLPGDGVQVVGTTDRDAVGALIQMPESVDVIVPRGGKGLVERIAREARVPVIKHLDGVCHVYI
DEAADTEKAVAIAVNAKTQRLGTCNTMETLLVAEAAAERVLPEVGRQLRDAGIEVRGCERTRALIDEAVPATEEDWTTEY
LGPTLAVRVVAGFDDAVAHIERYSSGHTEAIVTESYPLAQRFLREVDSSSVMVNASTRFADGQEYGLGAEIGISTDKLHA
RGPVGLEGLTTEKWIVLGDGHVRS
>Mature_423_residues
SAEHSSDIAETIRRIGQQARAAGRALARSGTGARNDALAAIAARIEAGSEAIAAANAADLEAAREAGLDPALIDRMELTP
GRIQAMADGLREIAALPDPVGAVRELASRPSGIQVGRMRMPIGVIGIIYESRPNVTADAAGLCIKSGNATILRGGSEAIR
SNRAIAEQIRAGLEDAGLPGDGVQVVGTTDRDAVGALIQMPESVDVIVPRGGKGLVERIAREARVPVIKHLDGVCHVYID
EAADTEKAVAIAVNAKTQRLGTCNTMETLLVAEAAAERVLPEVGRQLRDAGIEVRGCERTRALIDEAVPATEEDWTTEYL
GPTLAVRVVAGFDDAVAHIERYSSGHTEAIVTESYPLAQRFLREVDSSSVMVNASTRFADGQEYGLGAEIGISTDKLHAR
GPVGLEGLTTEKWIVLGDGHVRS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=416, Percent_Identity=37.0192307692308, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI21361368, Length=416, Percent_Identity=37.0192307692308, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=44.4711538461538, Blast_Score=363, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=38.4057971014493, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=38.4057971014493, Blast_Score=279, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=39.4431554524362, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=37.6528117359413, Blast_Score=264, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_HALHL (A1WYZ4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003708.1
- ProteinModelPortal:   A1WYZ4
- SMR:   A1WYZ4
- STRING:   A1WYZ4
- GeneID:   4711339
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2142
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   A1WYZ4
- BioCyc:   HHAL349124:HHAL_2142-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 44592; Mature: 44461

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAEHSSDIAETIRRIGQQARAAGRALARSGTGARNDALAAIAARIEAGSEAIAAANAAD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHCCHHH
LEAAREAGLDPALIDRMELTPGRIQAMADGLREIAALPDPVGAVRELASRPSGIQVGRMR
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECEEE
MPIGVIGIIYESRPNVTADAAGLCIKSGNATILRGGSEAIRSNRAIAEQIRAGLEDAGLP
CCEEEEEEEEECCCCCCCCCCCEEEECCCEEEEECCHHHHHCCHHHHHHHHCCHHHCCCC
GDGVQVVGTTDRDAVGALIQMPESVDVIVPRGGKGLVERIAREARVPVIKHLDGVCHVYI
CCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCEEEEEE
DEAADTEKAVAIAVNAKTQRLGTCNTMETLLVAEAAAERVLPEVGRQLRDAGIEVRGCER
ECCCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHH
TRALIDEAVPATEEDWTTEYLGPTLAVRVVAGFDDAVAHIERYSSGHTEAIVTESYPLAQ
HHHHHHHCCCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHH
RFLREVDSSSVMVNASTRFADGQEYGLGAEIGISTDKLHARGPVGLEGLTTEKWIVLGDG
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCC
HVRS
CCCC
>Mature Secondary Structure 
SAEHSSDIAETIRRIGQQARAAGRALARSGTGARNDALAAIAARIEAGSEAIAAANAAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHCCHHH
LEAAREAGLDPALIDRMELTPGRIQAMADGLREIAALPDPVGAVRELASRPSGIQVGRMR
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEECEEE
MPIGVIGIIYESRPNVTADAAGLCIKSGNATILRGGSEAIRSNRAIAEQIRAGLEDAGLP
CCEEEEEEEEECCCCCCCCCCCEEEECCCEEEEECCHHHHHCCHHHHHHHHCCHHHCCCC
GDGVQVVGTTDRDAVGALIQMPESVDVIVPRGGKGLVERIAREARVPVIKHLDGVCHVYI
CCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCEEEEEE
DEAADTEKAVAIAVNAKTQRLGTCNTMETLLVAEAAAERVLPEVGRQLRDAGIEVRGCER
ECCCCCCCEEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHH
TRALIDEAVPATEEDWTTEYLGPTLAVRVVAGFDDAVAHIERYSSGHTEAIVTESYPLAQ
HHHHHHHCCCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEECCCHHHH
RFLREVDSSSVMVNASTRFADGQEYGLGAEIGISTDKLHARGPVGLEGLTTEKWIVLGDG
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCC
HVRS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA