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The map label for this gene is trxA [H]

Identifier: 121998835

GI number: 121998835

Start: 2259486

End: 2259812

Strand: Reverse

Name: trxA [H]

Synonym: Hhal_2056

Alternate gene names: 121998835

Gene position: 2259812-2259486 (Counterclockwise)

Preceding gene: 121998836

Following gene: 121998834

Centisome position: 84.37

GC content: 63.0

Gene sequence:

>327_bases
GTGAGCGACGCAATCGTGCACGCCACCGACCAGAATTTCGAGCAGGAAGTGCTTCAAGCCAGCGTGCCCGTGCTGGTGGA
CTACTGGGCCGAGTGGTGTGGGCCCTGCAAGATGATCGGCCCCATCCTCGAAGAGATCGCCGCCGATTACGGCGACCGCC
TCAAGGTCGTCAAGCTGAATATCGACGAGAACCCCGAGACCCCGCCGAAGTACGGCATCCGCGGGATCCCCACGCTGATG
CTGTTCAAGGGCGGCAACGTCGAGGCCACCAAGGTCGGCGCCCTGTCCAAGTCCCAGCTGACCGCGTTCATCGACAGCAA
CCTGTAG

Upstream 100 bases:

>100_bases
CGGGATCCTCGGTTCCAATCAACGAGCAGTTTCCAATTATCCGAGCCCCGTGCAGCGGCTCCGCCCATATCGACGCAATC
GAACCTGGAGGTCTTCTACC

Downstream 100 bases:

>100_bases
AACAACTGCCGCAGCGCCGCCCCCGGCTTGAGTCCCGCGCCATCGCGCCCCTGCGGACGGCCGGCGGGCCGGCGCCCCCG
TGACCCTCCCCACGCCGAAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDAIVHATDQNFEQEVLQASVPVLVDYWAEWCGPCKMIGPILEEIAADYGDRLKVVKLNIDENPETPPKYGIRGIPTLM
LFKGGNVEATKVGALSKSQLTAFIDSNL

Sequences:

>Translated_108_residues
MSDAIVHATDQNFEQEVLQASVPVLVDYWAEWCGPCKMIGPILEEIAADYGDRLKVVKLNIDENPETPPKYGIRGIPTLM
LFKGGNVEATKVGALSKSQLTAFIDSNL
>Mature_107_residues
SDAIVHATDQNFEQEVLQASVPVLVDYWAEWCGPCKMIGPILEEIAADYGDRLKVVKLNIDENPETPPKYGIRGIPTLML
FKGGNVEATKVGALSKSQLTAFIDSNL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=35.4838709677419, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=67.5925925925926, Blast_Score=159, Evalue=4e-41,
Organism=Escherichia coli, GI1788936, Length=104, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=1e-19,
Organism=Escherichia coli, GI87081747, Length=83, Percent_Identity=34.9397590361446, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=40.8163265306122, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=40.2985074626866, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=107, Percent_Identity=30.8411214953271, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=40, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=39.5348837209302, Blast_Score=67, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639826, Length=83, Percent_Identity=43.3734939759036, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=44.5945945945946, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=32.2916666666667, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=34.1176470588235, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=34.1176470588235, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11836; Mature: 11705

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIVHATDQNFEQEVLQASVPVLVDYWAEWCGPCKMIGPILEEIAADYGDRLKVVKLN
CCCCEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEE
IDENPETPPKYGIRGIPTLMLFKGGNVEATKVGALSKSQLTAFIDSNL
CCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHEECCCC
>Mature Secondary Structure 
SDAIVHATDQNFEQEVLQASVPVLVDYWAEWCGPCKMIGPILEEIAADYGDRLKVVKLN
CCCEEECCCCCHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEE
IDENPETPPKYGIRGIPTLMLFKGGNVEATKVGALSKSQLTAFIDSNL
CCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496529 [H]