Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 121998461

GI number: 121998461

Start: 1835876

End: 1837420

Strand: Reverse

Name: guaB [H]

Synonym: Hhal_1682

Alternate gene names: 121998461

Gene position: 1837420-1835876 (Counterclockwise)

Preceding gene: 121998465

Following gene: 121998460

Centisome position: 68.6

GC content: 66.47

Gene sequence:

>1545_bases
GTGGGGGGCGCCCTGCACCGTAAAATACCGTGCTCTTTTCCATATTCAGACAGCGTCTCCGCCCGAGGTCCCGATACCAT
GCGAATCGCCCAGGAAGCCCTGACCTTCGATGATGTTCTCCTCCTTCCCGCTGAATCGCACGTGCTCCCTCGGGATGTGG
ATCTGTCCACGCCCCTGACGCGGCGGATCCAGGTTAACGTCCCGCTGGTGTCGGCGGCCATGGATACCGTGACGGAGGCG
CGGTTGGCCATCGCCCTGGCCGAGCAGGGCGGGATGGGGATCATCCACAAGAACATGACCGTCGAGCAACAGGCTGCCGA
GGTGCGTCGGGTCAAGAAGTTCGAGAGCGGGATCATCAAGGAGCCGATCACCGTCTCGCCCTTCATGACCATCGGCGAGG
TGCTCAAGCTCACGCGCCAGCACGGTATCTCTGGTGTCCCGGTGGTGGACGGCCAGGAACTGGTCGGCATCGTCACCGGC
CGCGACCTGCGCTTCGAGAATCGGGTCAGCGAGCCGGTCTCCGTGGCCATGACGCCCAAGGAGCGGCTGGTCACGGTGCG
TGAGGGGGCCGAGCGCGATGAGGTGCTGAGCAAGCTCCATCAGCACCGGATCGAGAAGATCCTGGTGGTTGATGACGCCT
TCCATCTGCGCGGCATGATCACCGTCAAAGACATCCAGAAGAGCCAGGACTTCCCCAACGCCTGCAAGGACGAGCACGGT
CGTCTGCGTGCCGGTGCCGCCGTGGGGGTGGGCGAAGGCACTGAAGAGCGCGCCGAGGCGCTGGGTGCGGCGGGCGTCGA
TGTGCTCGTGGTCGATACCGCCCACGGGCACTCTCGCGGGGTGATGGATCGGGTCCGCTGGGTCAAGCGCCACTACCCCG
ACGTGGAAGTGGTGGCCGGCAATATCGCCACCGGTGATGCGGCGAGGGCGCTTGCCGAGGCCGGTGCCGACGCCGTCAAG
GTGGGCATCGGGCCCGGGTCGATCTGCACCACCCGCGTCGTCGCCGGTGTCGGCGTCCCCCAGGTGACGGCGATCTCCAA
CGTGGCCCAGGCCCTGGCCGGTACCGATGTGCCGCTGATCGCCGACGGTGGGATCCGGTTCTCCGGGGATGCCGCAAAGG
CCCTAGCCAGCGGGGCCCATACGGTGATGGTGGGTAGCCTGCTCGCTGGCACCGAGGAGGCGCCGGGCGAGGTGGAGCTC
TATCAGGGACGCTCCTACAAGGCCTACCGCGGCATGGGATCGCTGGGGGCCATGTCCGGCAGCCAGGGGAGCGCCGACCG
CTACTTCCAGGAAGGCTCCCAGTCGGTGGACAAGCTGGTCCCCGAGGGGATCGAGGGCCGCGTCCCCTACAAGGGCAGTA
TGGTGACCATCGTCAACCAGATGATCGGGGGGATCCGCGCCAGTATGGGCTACGTGGGTTGCGCCACCATGGAGGAGATG
CGCACCCGGCCGCAGTTTGCCCGCATCACCGGTGCCGGCATGCGAGAGAGTCACGTGCACGACGTGACCATCACCAAGGA
AGCGCCCAACTACCGCGTCGAGTAA

Upstream 100 bases:

>100_bases
CGGCGGTATCGTCTCTACTGCGCTCCATACTCGGCGGCGGCTCGCTCCGGTTGGCTGATTACAAGCTACACGCCGCCATC
GCCCATGGGAAGTTTGTTGA

Downstream 100 bases:

>100_bases
TCATCTGGAGCCGTTGCCAGTGAGCGATCAGTCCGGGGCGGATATTCACGCCCACCGTATCCTTATTCTCGATTTCGGCT
CGCAGTACACCCAGCTCATC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MGGALHRKIPCSFPYSDSVSARGPDTMRIAQEALTFDDVLLLPAESHVLPRDVDLSTPLTRRIQVNVPLVSAAMDTVTEA
RLAIALAEQGGMGIIHKNMTVEQQAAEVRRVKKFESGIIKEPITVSPFMTIGEVLKLTRQHGISGVPVVDGQELVGIVTG
RDLRFENRVSEPVSVAMTPKERLVTVREGAERDEVLSKLHQHRIEKILVVDDAFHLRGMITVKDIQKSQDFPNACKDEHG
RLRAGAAVGVGEGTEERAEALGAAGVDVLVVDTAHGHSRGVMDRVRWVKRHYPDVEVVAGNIATGDAARALAEAGADAVK
VGIGPGSICTTRVVAGVGVPQVTAISNVAQALAGTDVPLIADGGIRFSGDAAKALASGAHTVMVGSLLAGTEEAPGEVEL
YQGRSYKAYRGMGSLGAMSGSQGSADRYFQEGSQSVDKLVPEGIEGRVPYKGSMVTIVNQMIGGIRASMGYVGCATMEEM
RTRPQFARITGAGMRESHVHDVTITKEAPNYRVE

Sequences:

>Translated_514_residues
MGGALHRKIPCSFPYSDSVSARGPDTMRIAQEALTFDDVLLLPAESHVLPRDVDLSTPLTRRIQVNVPLVSAAMDTVTEA
RLAIALAEQGGMGIIHKNMTVEQQAAEVRRVKKFESGIIKEPITVSPFMTIGEVLKLTRQHGISGVPVVDGQELVGIVTG
RDLRFENRVSEPVSVAMTPKERLVTVREGAERDEVLSKLHQHRIEKILVVDDAFHLRGMITVKDIQKSQDFPNACKDEHG
RLRAGAAVGVGEGTEERAEALGAAGVDVLVVDTAHGHSRGVMDRVRWVKRHYPDVEVVAGNIATGDAARALAEAGADAVK
VGIGPGSICTTRVVAGVGVPQVTAISNVAQALAGTDVPLIADGGIRFSGDAAKALASGAHTVMVGSLLAGTEEAPGEVEL
YQGRSYKAYRGMGSLGAMSGSQGSADRYFQEGSQSVDKLVPEGIEGRVPYKGSMVTIVNQMIGGIRASMGYVGCATMEEM
RTRPQFARITGAGMRESHVHDVTITKEAPNYRVE
>Mature_513_residues
GGALHRKIPCSFPYSDSVSARGPDTMRIAQEALTFDDVLLLPAESHVLPRDVDLSTPLTRRIQVNVPLVSAAMDTVTEAR
LAIALAEQGGMGIIHKNMTVEQQAAEVRRVKKFESGIIKEPITVSPFMTIGEVLKLTRQHGISGVPVVDGQELVGIVTGR
DLRFENRVSEPVSVAMTPKERLVTVREGAERDEVLSKLHQHRIEKILVVDDAFHLRGMITVKDIQKSQDFPNACKDEHGR
LRAGAAVGVGEGTEERAEALGAAGVDVLVVDTAHGHSRGVMDRVRWVKRHYPDVEVVAGNIATGDAARALAEAGADAVKV
GIGPGSICTTRVVAGVGVPQVTAISNVAQALAGTDVPLIADGGIRFSGDAAKALASGAHTVMVGSLLAGTEEAPGEVELY
QGRSYKAYRGMGSLGAMSGSQGSADRYFQEGSQSVDKLVPEGIEGRVPYKGSMVTIVNQMIGGIRASMGYVGCATMEEMR
TRPQFARITGAGMRESHVHDVTITKEAPNYRVE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=481, Percent_Identity=42.2037422037422, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI34328928, Length=458, Percent_Identity=43.2314410480349, Blast_Score=351, Evalue=9e-97,
Organism=Homo sapiens, GI34328930, Length=458, Percent_Identity=43.2314410480349, Blast_Score=351, Evalue=9e-97,
Organism=Homo sapiens, GI156616279, Length=458, Percent_Identity=43.2314410480349, Blast_Score=351, Evalue=9e-97,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=43.3628318584071, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI217035148, Length=481, Percent_Identity=41.3721413721414, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=40.3726708074534, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035150, Length=481, Percent_Identity=39.0852390852391, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=37.246963562753, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=36.8888888888889, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=66.3934426229508, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=35.2678571428571, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=506, Percent_Identity=34.5849802371541, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=428, Percent_Identity=37.3831775700935, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=36.0995850622407, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=41.2731006160164, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6322012, Length=508, Percent_Identity=39.3700787401575, Blast_Score=333, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.1656314699793, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=39.8826979472141, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=121, Percent_Identity=42.1487603305785, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.1304347826087, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.1304347826087, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=38.7755102040816, Blast_Score=282, Evalue=4e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54707; Mature: 54576

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGALHRKIPCSFPYSDSVSARGPDTMRIAQEALTFDDVLLLPAESHVLPRDVDLSTPLT
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCC
RRIQVNVPLVSAAMDTVTEARLAIALAEQGGMGIIHKNMTVEQQAAEVRRVKKFESGIIK
EEEEECCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
EPITVSPFMTIGEVLKLTRQHGISGVPVVDGQELVGIVTGRDLRFENRVSEPVSVAMTPK
CCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEECCCEECHHHCCCCEEEEECCH
ERLVTVREGAERDEVLSKLHQHRIEKILVVDDAFHLRGMITVKDIQKSQDFPNACKDEHG
HHEEEECCCCCHHHHHHHHHHHHHHEEEEEECCHHHEEEEEEHHHHHCCCCCCHHHCCCC
RLRAGAAVGVGEGTEERAEALGAAGVDVLVVDTAHGHSRGVMDRVRWVKRHYPDVEVVAG
CEEECEEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEC
NIATGDAARALAEAGADAVKVGIGPGSICTTRVVAGVGVPQVTAISNVAQALAGTDVPLI
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEE
ADGGIRFSGDAAKALASGAHTVMVGSLLAGTEEAPGEVELYQGRSYKAYRGMGSLGAMSG
ECCCEEECCHHHHHHHCCCHHEEHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCC
SQGSADRYFQEGSQSVDKLVPEGIEGRVPYKGSMVTIVNQMIGGIRASMGYVGCATMEEM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCHHHHHHH
RTRPQFARITGAGMRESHVHDVTITKEAPNYRVE
HCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
GGALHRKIPCSFPYSDSVSARGPDTMRIAQEALTFDDVLLLPAESHVLPRDVDLSTPLT
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCC
RRIQVNVPLVSAAMDTVTEARLAIALAEQGGMGIIHKNMTVEQQAAEVRRVKKFESGIIK
EEEEECCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
EPITVSPFMTIGEVLKLTRQHGISGVPVVDGQELVGIVTGRDLRFENRVSEPVSVAMTPK
CCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEECCCEECHHHCCCCEEEEECCH
ERLVTVREGAERDEVLSKLHQHRIEKILVVDDAFHLRGMITVKDIQKSQDFPNACKDEHG
HHEEEECCCCCHHHHHHHHHHHHHHEEEEEECCHHHEEEEEEHHHHHCCCCCCHHHCCCC
RLRAGAAVGVGEGTEERAEALGAAGVDVLVVDTAHGHSRGVMDRVRWVKRHYPDVEVVAG
CEEECEEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEC
NIATGDAARALAEAGADAVKVGIGPGSICTTRVVAGVGVPQVTAISNVAQALAGTDVPLI
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEE
ADGGIRFSGDAAKALASGAHTVMVGSLLAGTEEAPGEVELYQGRSYKAYRGMGSLGAMSG
ECCCEEECCHHHHHHHCCCHHEEHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCC
SQGSADRYFQEGSQSVDKLVPEGIEGRVPYKGSMVTIVNQMIGGIRASMGYVGCATMEEM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCHHHHHHH
RTRPQFARITGAGMRESHVHDVTITKEAPNYRVE
HCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA