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The map label for this gene is guaA

Identifier: 121998460

GI number: 121998460

Start: 1834267

End: 1835856

Strand: Reverse

Name: guaA

Synonym: Hhal_1681

Alternate gene names: 121998460

Gene position: 1835856-1834267 (Counterclockwise)

Preceding gene: 121998461

Following gene: 121998459

Centisome position: 68.54

GC content: 67.11

Gene sequence:

>1590_bases
GTGAGCGATCAGTCCGGGGCGGATATTCACGCCCACCGTATCCTTATTCTCGATTTCGGCTCGCAGTACACCCAGCTCAT
CGCCCGCCGCGTGCGCGAGTGCGGGGTGTACTGCGAGATCCGCGCCTGCGATGTCGCAGACCAGGCCGTGCGCGATTTCG
CCCCGTCCGGGGTCATCCTGTCTGGCGGCCCCGAGACAGTGACCGACGCAGAAACCCCGCGCATCCCGGCAGCGGTCTTC
GAGGTGGGCGTGCCGCTGCTCGGGATCTGCTACGGCATGCAGGCCATGGCCGCCCAGCTCGGGGGACGGGTCGCGCCCTC
CGAGCACAAGGAGTTCGGATACGCCCAGGTGCGTGCCCGCGGCCATTCGCGGCTGCTGCGCGATATCGAGGATCACGCCA
GCGCCGACGGCTACGGGTTGCTCGACGTCTGGATGAGCCACGGCGATCGGGTGGAGGCGCCGCCGGAGGGGTTCCTGGTG
ATCGCCGAGACCGAGGCCGCCCCGGTGGCCGGCATCGGAGACGATGATCGCGGCTGGTACGGGTTGCAGTTCCACCCGGA
GGTCACCCATACCGCGCAGGGAGGGCGCATCCTCGAGCGTTTCGTCCGCGAGATCTGCGGCTGTCCGGGGGACTGGACTC
CGGGGAATATCGTCGAGGACAGCATTGCCCGGGTGCGCGAGCAGGTCGGCGACCGCCACGTCGTCCTCGGGCTCTCCGGC
GGAGTGGATTCGTCGGTGACCGCCGCTCTGCTGCACCGAGCGATCGGCGACCAGCTGACGTGCGTGTTCGTCGATAACGG
CCTGCTGCGCCAGGGGGAGGCCGACCAGGTGATGGCCACCTTCGCCCGTCACATGGGCGTGCGGGTGATCCATATCGATG
CTGAGGACCGTTTCCTAACCGCCCTGTCCGGGGTCGAGGATCCTGAGGAGAAGCGGCGGATCATCGGCAACCTGTTCGTC
GAGATCTTTGACGAGGAGGCCGGAAAGCTCCAGGGCGTCGATTTCCTCGCCCAGGGTACGATCTACCCCGACGTGGTGGA
GTCGGCGGGCAACGCCGGAGGTAAGTCTCACGTCATCAAGTCCCACCACAACGTGGGCGGACTGCCCGAGACCATGAAGC
TCAAACTCGTCGAGCCGCTGCGCGAGCTGTTCAAAGACGAGGTGCGGCGGGTTGGGCTGGAGCTGGGGCTGCCGGCAGAC
ATGCTCTACCGTCACCCCTTCCCGGGGCCGGGGCTGGGGGTGCGCATCCTGGGCGAGGTCCACAAGCGCTACGCCGATCT
GCTGCGACGGGCAGATGCGATCTTCATCGAGGAGCTGCGTCGGTGGGACTGGTACGACCGTACCAGTCAGGCCTTTGCGG
TCTTCCTGCCGGTGCGCTCGGTGGGCGTGACCGGGGACGGGCGGCGCTATGAGTACGTGGTCGCCCTGCGCGCCGTGGAG
ACCGTGGATTTCATGACCGCGCGTTGGGCGCAGCTGCCGTACGAGTTCCTCGATCACGTCTCCCGGCGGATCATCAACGA
GATCGACGGCATCTCCCGCGTTGTCTACGACATCTCGGGCAAACCTCCGGCGACCATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
ATCACCGGTGCCGGCATGCGAGAGAGTCACGTGCACGACGTGACCATCACCAAGGAAGCGCCCAACTACCGCGTCGAGTA
ATCATCTGGAGCCGTTGCCA

Downstream 100 bases:

>100_bases
GTGGGGCGCGCGCCGATGCGGCCTGGATGGCGCGAGCGCTGGAGTTGGCGCGATATGCCGCGGACCAGGGCGAGGTGCCC
GTGGGGGCGGTGGTGGTCCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MSDQSGADIHAHRILILDFGSQYTQLIARRVRECGVYCEIRACDVADQAVRDFAPSGVILSGGPETVTDAETPRIPAAVF
EVGVPLLGICYGMQAMAAQLGGRVAPSEHKEFGYAQVRARGHSRLLRDIEDHASADGYGLLDVWMSHGDRVEAPPEGFLV
IAETEAAPVAGIGDDDRGWYGLQFHPEVTHTAQGGRILERFVREICGCPGDWTPGNIVEDSIARVREQVGDRHVVLGLSG
GVDSSVTAALLHRAIGDQLTCVFVDNGLLRQGEADQVMATFARHMGVRVIHIDAEDRFLTALSGVEDPEEKRRIIGNLFV
EIFDEEAGKLQGVDFLAQGTIYPDVVESAGNAGGKSHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRRVGLELGLPAD
MLYRHPFPGPGLGVRILGEVHKRYADLLRRADAIFIEELRRWDWYDRTSQAFAVFLPVRSVGVTGDGRRYEYVVALRAVE
TVDFMTARWAQLPYEFLDHVSRRIINEIDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_529_residues
MSDQSGADIHAHRILILDFGSQYTQLIARRVRECGVYCEIRACDVADQAVRDFAPSGVILSGGPETVTDAETPRIPAAVF
EVGVPLLGICYGMQAMAAQLGGRVAPSEHKEFGYAQVRARGHSRLLRDIEDHASADGYGLLDVWMSHGDRVEAPPEGFLV
IAETEAAPVAGIGDDDRGWYGLQFHPEVTHTAQGGRILERFVREICGCPGDWTPGNIVEDSIARVREQVGDRHVVLGLSG
GVDSSVTAALLHRAIGDQLTCVFVDNGLLRQGEADQVMATFARHMGVRVIHIDAEDRFLTALSGVEDPEEKRRIIGNLFV
EIFDEEAGKLQGVDFLAQGTIYPDVVESAGNAGGKSHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRRVGLELGLPAD
MLYRHPFPGPGLGVRILGEVHKRYADLLRRADAIFIEELRRWDWYDRTSQAFAVFLPVRSVGVTGDGRRYEYVVALRAVE
TVDFMTARWAQLPYEFLDHVSRRIINEIDGISRVVYDISGKPPATIEWE
>Mature_528_residues
SDQSGADIHAHRILILDFGSQYTQLIARRVRECGVYCEIRACDVADQAVRDFAPSGVILSGGPETVTDAETPRIPAAVFE
VGVPLLGICYGMQAMAAQLGGRVAPSEHKEFGYAQVRARGHSRLLRDIEDHASADGYGLLDVWMSHGDRVEAPPEGFLVI
AETEAAPVAGIGDDDRGWYGLQFHPEVTHTAQGGRILERFVREICGCPGDWTPGNIVEDSIARVREQVGDRHVVLGLSGG
VDSSVTAALLHRAIGDQLTCVFVDNGLLRQGEADQVMATFARHMGVRVIHIDAEDRFLTALSGVEDPEEKRRIIGNLFVE
IFDEEAGKLQGVDFLAQGTIYPDVVESAGNAGGKSHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRRVGLELGLPADM
LYRHPFPGPGLGVRILGEVHKRYADLLRRADAIFIEELRRWDWYDRTSQAFAVFLPVRSVGVTGDGRRYEYVVALRAVET
VDFMTARWAQLPYEFLDHVSRRIINEIDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=578, Percent_Identity=34.9480968858132, Blast_Score=298, Evalue=1e-80,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=69.9233716475096, Blast_Score=771, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=576, Percent_Identity=35.2430555555556, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=576, Percent_Identity=35.0694444444444, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=576, Percent_Identity=35.0694444444444, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=525, Percent_Identity=48.1904761904762, Blast_Score=514, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=33.9892665474061, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58376; Mature: 58245

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQSGADIHAHRILILDFGSQYTQLIARRVRECGVYCEIRACDVADQAVRDFAPSGVIL
CCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCEEE
SGGPETVTDAETPRIPAAVFEVGVPLLGICYGMQAMAAQLGGRVAPSEHKEFGYAQVRAR
CCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHH
GHSRLLRDIEDHASADGYGLLDVWMSHGDRVEAPPEGFLVIAETEAAPVAGIGDDDRGWY
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEE
GLQFHPEVTHTAQGGRILERFVREICGCPGDWTPGNIVEDSIARVREQVGDRHVVLGLSG
EEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
GVDSSVTAALLHRAIGDQLTCVFVDNGLLRQGEADQVMATFARHMGVRVIHIDAEDRFLT
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHH
ALSGVEDPEEKRRIIGNLFVEIFDEEAGKLQGVDFLAQGTIYPDVVESAGNAGGKSHVIK
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCHHHHHHCCCCCCCCCHHH
SHHNVGGLPETMKLKLVEPLRELFKDEVRRVGLELGLPADMLYRHPFPGPGLGVRILGEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHH
HKRYADLLRRADAIFIEELRRWDWYDRTSQAFAVFLPVRSVGVTGDGRRYEYVVALRAVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEEEEHHHHH
TVDFMTARWAQLPYEFLDHVSRRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SDQSGADIHAHRILILDFGSQYTQLIARRVRECGVYCEIRACDVADQAVRDFAPSGVIL
CCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCEEE
SGGPETVTDAETPRIPAAVFEVGVPLLGICYGMQAMAAQLGGRVAPSEHKEFGYAQVRAR
CCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHH
GHSRLLRDIEDHASADGYGLLDVWMSHGDRVEAPPEGFLVIAETEAAPVAGIGDDDRGWY
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEE
GLQFHPEVTHTAQGGRILERFVREICGCPGDWTPGNIVEDSIARVREQVGDRHVVLGLSG
EEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
GVDSSVTAALLHRAIGDQLTCVFVDNGLLRQGEADQVMATFARHMGVRVIHIDAEDRFLT
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCHHHH
ALSGVEDPEEKRRIIGNLFVEIFDEEAGKLQGVDFLAQGTIYPDVVESAGNAGGKSHVIK
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCHHHHHHCCCCCCCCCHHH
SHHNVGGLPETMKLKLVEPLRELFKDEVRRVGLELGLPADMLYRHPFPGPGLGVRILGEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHH
HKRYADLLRRADAIFIEELRRWDWYDRTSQAFAVFLPVRSVGVTGDGRRYEYVVALRAVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEEEEHHHHH
TVDFMTARWAQLPYEFLDHVSRRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA