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The map label for this gene is aceA [H]

Identifier: 121998184

GI number: 121998184

Start: 1514973

End: 1516241

Strand: Reverse

Name: aceA [H]

Synonym: Hhal_1402

Alternate gene names: 121998184

Gene position: 1516241-1514973 (Counterclockwise)

Preceding gene: 121998192

Following gene: 121998183

Centisome position: 56.61

GC content: 65.33

Gene sequence:

>1269_bases
ATGTTGAAAGATCAAGCGGCGATTGAGCGTGACTGGGCGGAGAACCCGCGCTGGAAAGGGGTGCAGCGGGGCTACGGGGC
CGATGAGGTCGTCCGTCTCCGGGGGACCGTGCACGTCGAGTACAGCCTGGCGCGCCAGGGTGCAGAGAAGCTGTGGCAGT
CCATGCACGAGATGCCCTACGTCAACGCCCTCGGCGCCCTGACCGGCAACCAGGCCCTGCAGCAGGTCAAGGCCGGGCTC
AACGCCATCTACCTCTCGGGCTGGCAGGTGGCCGCCGACGCCAACCTCGGTCAGACCATGTATCCCGACCAGTCGCTCTA
CCCGGCGAACTCAGTCCCTGCGGTGGTCGATCGCATCAACAACGCGCTGCTGCGCGCCGACGAGATCAACCACGCCGAGG
GCAACCCGCCGTTCGACTTCATGAAGCCCATCGTGGCGGACGCCGAGGCCGGTTTCGGCGGCGTGCTGAACGCCTTTGAG
CTGATGAAGGGGATGATCCGCGCCGGTGCCGCGGGGGTCCACTTCGAGGATCAGCTGGCTTCGGTGAAGAAGTGCGGCCA
CATGGGCGGCAAGGTGCTGCTGCCCACCCAGGAGGCGGTGCAGAAGCTCATCGCTGCGCGCCTGGCGGCCGACACCATGG
ATGTGCCGACCATCCTGGTCGCCCGTACGGACGCCGAGGCGGCAGACCTGCTGACCTCCGACGTGGACGACAACGACAAG
CCGTTCATTACCGGCGAGCGCACTGCGGAGGGCTTTTTCCGCACCAAGCCGGGCATCGAGCAGGCCATCAGCCGCGGCCT
CGCCTACGCCCCTTACGCCGACGTGATCTGGTGCGAGACCGGCAAGCCGGATCTCGAATTCGCCCGCGAATTCGCGCAGG
CCATTCACGAGAAGTATCCCGGCAAGCTGCTCGCCTACAACTGCTCGCCGTCGTTCAATTGGGCGGGCAACCTGGACGAG
GCCACCATCCGCAAGTTCCAGGATGAGCTCGGTAAGATGGGCTTCAAGTTCCAGTTCATCACGCTGGCCGGCTTCCACTC
GCTCAACTACTCGATGTTCGAGCTGGCCCGCGGCTACAAGGAGCGGCAGATGGAGGCGTACTCCGAGCTGCAGCAGGCGG
AGTTTGCCGCGGAGAAACACGGTTACACCGCGACCCGTCACCAGCGGGAGGTGGGCGCCGGCTACTTCGACCAGGTCACC
AACGTGATCCAGGGCGGCCAGTCCTCGGTGACAGCGCTGAAGGGGTCGACGGAGGAAGAGCAGTTCTAA

Upstream 100 bases:

>100_bases
CGAGGGCAACCGCGACGGCCCCTCGGGCCGACAGCCATTGACCGTCATACAAGATTTTCGGGGGTACGGTGTACCAGCCC
GACTTGGGAGGCAGAGACTG

Downstream 100 bases:

>100_bases
CGTCGGTCGCGCCCCGACGCGCGAAGCCTCAGGACCCCGGGACGGTGTAGCCACCGCCCCGGGGTTTTTTTATGGTGACG
GTGCGCTCTGACATTGGCCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLKDQAAIERDWAENPRWKGVQRGYGADEVVRLRGTVHVEYSLARQGAEKLWQSMHEMPYVNALGALTGNQALQQVKAGL
NAIYLSGWQVAADANLGQTMYPDQSLYPANSVPAVVDRINNALLRADEINHAEGNPPFDFMKPIVADAEAGFGGVLNAFE
LMKGMIRAGAAGVHFEDQLASVKKCGHMGGKVLLPTQEAVQKLIAARLAADTMDVPTILVARTDAEAADLLTSDVDDNDK
PFITGERTAEGFFRTKPGIEQAISRGLAYAPYADVIWCETGKPDLEFAREFAQAIHEKYPGKLLAYNCSPSFNWAGNLDE
ATIRKFQDELGKMGFKFQFITLAGFHSLNYSMFELARGYKERQMEAYSELQQAEFAAEKHGYTATRHQREVGAGYFDQVT
NVIQGGQSSVTALKGSTEEEQF

Sequences:

>Translated_422_residues
MLKDQAAIERDWAENPRWKGVQRGYGADEVVRLRGTVHVEYSLARQGAEKLWQSMHEMPYVNALGALTGNQALQQVKAGL
NAIYLSGWQVAADANLGQTMYPDQSLYPANSVPAVVDRINNALLRADEINHAEGNPPFDFMKPIVADAEAGFGGVLNAFE
LMKGMIRAGAAGVHFEDQLASVKKCGHMGGKVLLPTQEAVQKLIAARLAADTMDVPTILVARTDAEAADLLTSDVDDNDK
PFITGERTAEGFFRTKPGIEQAISRGLAYAPYADVIWCETGKPDLEFAREFAQAIHEKYPGKLLAYNCSPSFNWAGNLDE
ATIRKFQDELGKMGFKFQFITLAGFHSLNYSMFELARGYKERQMEAYSELQQAEFAAEKHGYTATRHQREVGAGYFDQVT
NVIQGGQSSVTALKGSTEEEQF
>Mature_422_residues
MLKDQAAIERDWAENPRWKGVQRGYGADEVVRLRGTVHVEYSLARQGAEKLWQSMHEMPYVNALGALTGNQALQQVKAGL
NAIYLSGWQVAADANLGQTMYPDQSLYPANSVPAVVDRINNALLRADEINHAEGNPPFDFMKPIVADAEAGFGGVLNAFE
LMKGMIRAGAAGVHFEDQLASVKKCGHMGGKVLLPTQEAVQKLIAARLAADTMDVPTILVARTDAEAADLLTSDVDDNDK
PFITGERTAEGFFRTKPGIEQAISRGLAYAPYADVIWCETGKPDLEFAREFAQAIHEKYPGKLLAYNCSPSFNWAGNLDE
ATIRKFQDELGKMGFKFQFITLAGFHSLNYSMFELARGYKERQMEAYSELQQAEFAAEKHGYTATRHQREVGAGYFDQVT
NVIQGGQSSVTALKGSTEEEQF

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=425, Percent_Identity=68.7058823529412, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1786525, Length=288, Percent_Identity=26.3888888888889, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=61.7433414043584, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=61.7433414043584, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320908, Length=302, Percent_Identity=37.0860927152318, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=249, Percent_Identity=34.5381526104418, Blast_Score=140, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46478; Mature: 46478

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDQAAIERDWAENPRWKGVQRGYGADEVVRLRGTVHVEYSLARQGAEKLWQSMHEMPY
CCCCHHHHHHHHCCCCCCCCHHCCCCCCCEEEEECEEEEEHHHHHHHHHHHHHHHHHCCH
VNALGALTGNQALQQVKAGLNAIYLSGWQVAADANLGQTMYPDQSLYPANSVPAVVDRIN
HHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
NALLRADEINHAEGNPPFDFMKPIVADAEAGFGGVLNAFELMKGMIRAGAAGVHFEDQLA
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SVKKCGHMGGKVLLPTQEAVQKLIAARLAADTMDVPTILVARTDAEAADLLTSDVDDNDK
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
PFITGERTAEGFFRTKPGIEQAISRGLAYAPYADVIWCETGKPDLEFAREFAQAIHEKYP
CEECCCCCCCCHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCC
GKLLAYNCSPSFNWAGNLDEATIRKFQDELGKMGFKFQFITLAGFHSLNYSMFELARGYK
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECHHHCCHHHHHHHHHHH
ERQMEAYSELQQAEFAAEKHGYTATRHQREVGAGYFDQVTNVIQGGQSSVTALKGSTEEE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCCCC
QF
CC
>Mature Secondary Structure
MLKDQAAIERDWAENPRWKGVQRGYGADEVVRLRGTVHVEYSLARQGAEKLWQSMHEMPY
CCCCHHHHHHHHCCCCCCCCHHCCCCCCCEEEEECEEEEEHHHHHHHHHHHHHHHHHCCH
VNALGALTGNQALQQVKAGLNAIYLSGWQVAADANLGQTMYPDQSLYPANSVPAVVDRIN
HHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHH
NALLRADEINHAEGNPPFDFMKPIVADAEAGFGGVLNAFELMKGMIRAGAAGVHFEDQLA
HHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SVKKCGHMGGKVLLPTQEAVQKLIAARLAADTMDVPTILVARTDAEAADLLTSDVDDNDK
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
PFITGERTAEGFFRTKPGIEQAISRGLAYAPYADVIWCETGKPDLEFAREFAQAIHEKYP
CEECCCCCCCCHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCC
GKLLAYNCSPSFNWAGNLDEATIRKFQDELGKMGFKFQFITLAGFHSLNYSMFELARGYK
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECHHHCCHHHHHHHHHHH
ERQMEAYSELQQAEFAAEKHGYTATRHQREVGAGYFDQVTNVIQGGQSSVTALKGSTEEE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCCCCC
QF
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]