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The map label for this gene is clpA [H]

Identifier: 121998182

GI number: 121998182

Start: 1512168

End: 1514438

Strand: Reverse

Name: clpA [H]

Synonym: Hhal_1400

Alternate gene names: 121998182

Gene position: 1514438-1512168 (Counterclockwise)

Preceding gene: 121998183

Following gene: 121998178

Centisome position: 56.54

GC content: 65.08

Gene sequence:

>2271_bases
ATGCTAAGTAAAGAGTTAGAGTTCACGCTCAATCTGGCTTTCAAGGACGCACGGGAGAAGCGCCACGAGTTCCTCACCGT
TGAGCACCTCTTGCTGGCCTTGACCGACAACCCCGCTGCCTCGCAGGTGCTCAAGGCCTGTGGCGCCGATCTCGAGCGGC
TGCGGGGGGAGTTACAAGCCTTCCTGTCCGAGACCACGCCGCTGCTCCCGGTAAACGACAGCCGCGAGACGCAGCCGACG
CTCGGGTTCCAGCGGGTCCTGCAGCGCGCCATCCTCCACGTGCAGTCCTCCGGCAAGCGTGAGGTCACCGGAGCCAACGT
ACTGGTGGCCATCTTCAGCGAGCAGGAGTCCCAGGCGGTCTACTTTCTGCACAAGCAGAACATCTCTCGCCTGGACGTGG
TGAACTACATTTCCCACGGCATCTCCTCGGTCGGGGGTGAAGAAGACATGGGCAAGGAAGAGAGTGGCCCGGCGGATGAA
GAGGGCGCAGCGGAGCCGACCCAGGGCGGGTCGCCGCTGGAGCAGTACGCCACCAACCTGAATCAGCGGGCCCGCTCCGG
GCAGATCGACCCGCTGATCGGTCGTCGTTACGAGATCGAGCGGACGGTCCAGGTGCTCTGCCGGCGCCGCAAGAACAACC
CGCTGTTCGTCGGCGAGGCCGGTGTCGGCAAGACCGCCATCGCCGAGGGGCTGGCCAAGCAGATCGTCGAGGGCGAGGTG
CCGGAGGTGCTCCGGGAGAGCACTATCTACTCGCTGGATCTCGGTGCCCTGGTGGCCGGTACCAAGTACCGTGGCGACTT
CGAGAAGCGCCTCAAGGCGTTGCTCCACCAGCTCAAAAAGGACAGCGGCTCCATCCTGTTCATCGACGAGATCCACACCA
TCATCGGAGCTGGGTCGGCCTCCGGTGGGGTGATGGACGCCTCGAACCTGATCAAGCCGATGCTCGCCTCCGGCGAGCTG
CGCTGCATCGGATCGACCACGTATCAGGAGTACCGCGGTATCTTCGAAAAGGATCGGGCCCTGGCCCGGCGCTTCCAGAA
GATCGATGTCAGCGAGCCGTCGGTGGAGGATACCGTCCAGATCCTCAAGGGGCTGAAGAGCCGCTTCGAGGAGCACCACA
ATGTCCGCTTCACGGAGCCAGCCCTGCAAGCGGCGGCGGAGTTGTCGGCCAAGTACATCAATGACCGGCGCCTGCCCGAC
AAGGCCATCGACGTCATCGACGAGGCCGGCGCCCGGCTGCGCCTGCGCCCGCGCTCGAAGCGGCGCAAGACGGTGGGCCT
GCCGGATATCGAGTCGATCGTGGCGAAGATCGCGCGGATCCCCCCCAAGCGGGTCTCCAGCCAGGACATGAAGGTGCTCG
AGAACCTCGAGGGCGAGCTCAAGGGACTGATCTTCGGTCAGGACGAGGCCATCGAGAGCCTGGCGTCGACCATCAAGATG
TCTCGGGCCGGGCTGGGTACGCCGGATCGGCCGGTGGGCACCTTCCTGTTTGCCGGTCCCACCGGCGTGGGCAAGACCGA
GGTGACCCGACAGTTGGCCGAGGTGACCGGTGTCCAGATGATCCGCTTCGACATGTCCGAGTATATGGAGCGGCACACCG
TCTCGCGGCTGATCGGTGCCCCTCCGGGGTACGTCGGCTACGACCAGGGCGGGCTGCTCACCGAGGAGGTCATCAAGCAC
CCGCACTCGGTACTGCTGCTCGACGAGATCGAGAAGGCCCATCCGGACGTGTTCAACCTGCTGCTGCAGGTGATGGATCA
CGGCACGCTGACGGACAACAACGGCCGCGAGGCGGACTTCCGCAACGTGGTGCTGGTGATGACCACCAACGCCGGGGCTG
AGGAGATGAGCAAGCGCTCGATCGGCTTCACCAACGAGAGCGACACCCAGGACAGCATGGAGGCGATCCGGCGGACCTTC
TCCCCGGAGTTCCGCAACCGCATCGATGCGGTGGTGCAGTTCCAGCCCCTGGGTCAGGACACCGTGCAGCGGGTGGTCGA
CAAGTTCATCCGCGAGCTGTCGGTGCAGCTGGCCGAGAAGCGTGTCACCCTGGTCGTCGACGGCGACGCGCGACGGTGGA
TCGGGGAGAAGGGCTATGACCCGCAGATGGGTGCACGCCCGATGGCCCGAGTCATCCAGCAGCACATCAAGAAGCCGCTG
GCCGAGCAGCTGCTCTTCGGCGAGCTGACCGGTGGTGGCGAGGTCGAGGTCACGGTCGAGGATGGCGAGCTGACCATCCA
CGTCCGGGAGAGGGATACCGAGGGGGCGTAG

Upstream 100 bases:

>100_bases
ACGATGGAGGAAGCTTGAATCGTTCCAGGAACCGTGGCGCGGTTGTCCGGTCCAATCCGGGGGTGGTTCCCCGGTCAAGC
CCCAGGCGAGGTAATAGGGC

Downstream 100 bases:

>100_bases
GCCCGACGGGCCGGTGCTTCCGCCAGCCCCGGCCGAGCCGTGCTTGGCTGGGGTTGGCCCGTTACCGCTCGCGGTAGACG
ATGCGCCCCTTGTTCAGGTC

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MLSKELEFTLNLAFKDAREKRHEFLTVEHLLLALTDNPAASQVLKACGADLERLRGELQAFLSETTPLLPVNDSRETQPT
LGFQRVLQRAILHVQSSGKREVTGANVLVAIFSEQESQAVYFLHKQNISRLDVVNYISHGISSVGGEEDMGKEESGPADE
EGAAEPTQGGSPLEQYATNLNQRARSGQIDPLIGRRYEIERTVQVLCRRRKNNPLFVGEAGVGKTAIAEGLAKQIVEGEV
PEVLRESTIYSLDLGALVAGTKYRGDFEKRLKALLHQLKKDSGSILFIDEIHTIIGAGSASGGVMDASNLIKPMLASGEL
RCIGSTTYQEYRGIFEKDRALARRFQKIDVSEPSVEDTVQILKGLKSRFEEHHNVRFTEPALQAAAELSAKYINDRRLPD
KAIDVIDEAGARLRLRPRSKRRKTVGLPDIESIVAKIARIPPKRVSSQDMKVLENLEGELKGLIFGQDEAIESLASTIKM
SRAGLGTPDRPVGTFLFAGPTGVGKTEVTRQLAEVTGVQMIRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTEEVIKH
PHSVLLLDEIEKAHPDVFNLLLQVMDHGTLTDNNGREADFRNVVLVMTTNAGAEEMSKRSIGFTNESDTQDSMEAIRRTF
SPEFRNRIDAVVQFQPLGQDTVQRVVDKFIRELSVQLAEKRVTLVVDGDARRWIGEKGYDPQMGARPMARVIQQHIKKPL
AEQLLFGELTGGGEVEVTVEDGELTIHVRERDTEGA

Sequences:

>Translated_756_residues
MLSKELEFTLNLAFKDAREKRHEFLTVEHLLLALTDNPAASQVLKACGADLERLRGELQAFLSETTPLLPVNDSRETQPT
LGFQRVLQRAILHVQSSGKREVTGANVLVAIFSEQESQAVYFLHKQNISRLDVVNYISHGISSVGGEEDMGKEESGPADE
EGAAEPTQGGSPLEQYATNLNQRARSGQIDPLIGRRYEIERTVQVLCRRRKNNPLFVGEAGVGKTAIAEGLAKQIVEGEV
PEVLRESTIYSLDLGALVAGTKYRGDFEKRLKALLHQLKKDSGSILFIDEIHTIIGAGSASGGVMDASNLIKPMLASGEL
RCIGSTTYQEYRGIFEKDRALARRFQKIDVSEPSVEDTVQILKGLKSRFEEHHNVRFTEPALQAAAELSAKYINDRRLPD
KAIDVIDEAGARLRLRPRSKRRKTVGLPDIESIVAKIARIPPKRVSSQDMKVLENLEGELKGLIFGQDEAIESLASTIKM
SRAGLGTPDRPVGTFLFAGPTGVGKTEVTRQLAEVTGVQMIRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTEEVIKH
PHSVLLLDEIEKAHPDVFNLLLQVMDHGTLTDNNGREADFRNVVLVMTTNAGAEEMSKRSIGFTNESDTQDSMEAIRRTF
SPEFRNRIDAVVQFQPLGQDTVQRVVDKFIRELSVQLAEKRVTLVVDGDARRWIGEKGYDPQMGARPMARVIQQHIKKPL
AEQLLFGELTGGGEVEVTVEDGELTIHVRERDTEGA
>Mature_756_residues
MLSKELEFTLNLAFKDAREKRHEFLTVEHLLLALTDNPAASQVLKACGADLERLRGELQAFLSETTPLLPVNDSRETQPT
LGFQRVLQRAILHVQSSGKREVTGANVLVAIFSEQESQAVYFLHKQNISRLDVVNYISHGISSVGGEEDMGKEESGPADE
EGAAEPTQGGSPLEQYATNLNQRARSGQIDPLIGRRYEIERTVQVLCRRRKNNPLFVGEAGVGKTAIAEGLAKQIVEGEV
PEVLRESTIYSLDLGALVAGTKYRGDFEKRLKALLHQLKKDSGSILFIDEIHTIIGAGSASGGVMDASNLIKPMLASGEL
RCIGSTTYQEYRGIFEKDRALARRFQKIDVSEPSVEDTVQILKGLKSRFEEHHNVRFTEPALQAAAELSAKYINDRRLPD
KAIDVIDEAGARLRLRPRSKRRKTVGLPDIESIVAKIARIPPKRVSSQDMKVLENLEGELKGLIFGQDEAIESLASTIKM
SRAGLGTPDRPVGTFLFAGPTGVGKTEVTRQLAEVTGVQMIRFDMSEYMERHTVSRLIGAPPGYVGYDQGGLLTEEVIKH
PHSVLLLDEIEKAHPDVFNLLLQVMDHGTLTDNNGREADFRNVVLVMTTNAGAEEMSKRSIGFTNESDTQDSMEAIRRTF
SPEFRNRIDAVVQFQPLGQDTVQRVVDKFIRELSVQLAEKRVTLVVDGDARRWIGEKGYDPQMGARPMARVIQQHIKKPL
AEQLLFGELTGGGEVEVTVEDGELTIHVRERDTEGA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=31.4641744548287, Blast_Score=167, Evalue=4e-41,
Organism=Escherichia coli, GI1787109, Length=748, Percent_Identity=66.9786096256685, Blast_Score=1036, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=420, Percent_Identity=43.8095238095238, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=249, Percent_Identity=57.429718875502, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=412, Percent_Identity=36.8932038834951, Blast_Score=250, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83699; Mature: 83699

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSKELEFTLNLAFKDAREKRHEFLTVEHLLLALTDNPAASQVLKACGADLERLRGELQA
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHH
FLSETTPLLPVNDSRETQPTLGFQRVLQRAILHVQSSGKREVTGANVLVAIFSEQESQAV
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCEE
YFLHKQNISRLDVVNYISHGISSVGGEEDMGKEESGPADEEGAAEPTQGGSPLEQYATNL
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
NQRARSGQIDPLIGRRYEIERTVQVLCRRRKNNPLFVGEAGVGKTAIAEGLAKQIVEGEV
HHHHHCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCH
PEVLRESTIYSLDLGALVAGTKYRGDFEKRLKALLHQLKKDSGSILFIDEIHTIIGAGSA
HHHHHHHCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCC
SGGVMDASNLIKPMLASGELRCIGSTTYQEYRGIFEKDRALARRFQKIDVSEPSVEDTVQ
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILKGLKSRFEEHHNVRFTEPALQAAAELSAKYINDRRLPDKAIDVIDEAGARLRLRPRSK
HHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHH
RRKTVGLPDIESIVAKIARIPPKRVSSQDMKVLENLEGELKGLIFGQDEAIESLASTIKM
CCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHCHHHCEEEECCHHHHHHHHHHHHH
SRAGLGTPDRPVGTFLFAGPTGVGKTEVTRQLAEVTGVQMIRFDMSEYMERHTVSRLIGA
HHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPGYVGYDQGGLLTEEVIKHPHSVLLLDEIEKAHPDVFNLLLQVMDHGTLTDNNGREADF
CCCCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
RNVVLVMTTNAGAEEMSKRSIGFTNESDTQDSMEAIRRTFSPEFRNRIDAVVQFQPLGQD
CCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHEEECCCCHH
TVQRVVDKFIRELSVQLAEKRVTLVVDGDARRWIGEKGYDPQMGARPMARVIQQHIKKPL
HHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
AEQLLFGELTGGGEVEVTVEDGELTIHVRERDTEGA
HHHHHHHCCCCCCEEEEEEECCEEEEEEECCCCCCC
>Mature Secondary Structure
MLSKELEFTLNLAFKDAREKRHEFLTVEHLLLALTDNPAASQVLKACGADLERLRGELQA
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHH
FLSETTPLLPVNDSRETQPTLGFQRVLQRAILHVQSSGKREVTGANVLVAIFSEQESQAV
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCEE
YFLHKQNISRLDVVNYISHGISSVGGEEDMGKEESGPADEEGAAEPTQGGSPLEQYATNL
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
NQRARSGQIDPLIGRRYEIERTVQVLCRRRKNNPLFVGEAGVGKTAIAEGLAKQIVEGEV
HHHHHCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCH
PEVLRESTIYSLDLGALVAGTKYRGDFEKRLKALLHQLKKDSGSILFIDEIHTIIGAGSA
HHHHHHHCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCC
SGGVMDASNLIKPMLASGELRCIGSTTYQEYRGIFEKDRALARRFQKIDVSEPSVEDTVQ
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ILKGLKSRFEEHHNVRFTEPALQAAAELSAKYINDRRLPDKAIDVIDEAGARLRLRPRSK
HHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHH
RRKTVGLPDIESIVAKIARIPPKRVSSQDMKVLENLEGELKGLIFGQDEAIESLASTIKM
CCCCCCCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHCHHHCEEEECCHHHHHHHHHHHHH
SRAGLGTPDRPVGTFLFAGPTGVGKTEVTRQLAEVTGVQMIRFDMSEYMERHTVSRLIGA
HHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPGYVGYDQGGLLTEEVIKHPHSVLLLDEIEKAHPDVFNLLLQVMDHGTLTDNNGREADF
CCCCCCCCCCCCCHHHHHCCCCCEEEHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
RNVVLVMTTNAGAEEMSKRSIGFTNESDTQDSMEAIRRTFSPEFRNRIDAVVQFQPLGQD
CCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHEEECCCCHH
TVQRVVDKFIRELSVQLAEKRVTLVVDGDARRWIGEKGYDPQMGARPMARVIQQHIKKPL
HHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
AEQLLFGELTGGGEVEVTVEDGELTIHVRERDTEGA
HHHHHHHCCCCCCEEEEEEECCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]