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The map label for this gene is serS

Identifier: 121998174

GI number: 121998174

Start: 1503047

End: 1504324

Strand: Reverse

Name: serS

Synonym: Hhal_1392

Alternate gene names: 121998174

Gene position: 1504324-1503047 (Counterclockwise)

Preceding gene: 121998175

Following gene: 121998172

Centisome position: 56.16

GC content: 67.53

Gene sequence:

>1278_bases
ATGATCGACCCCAAACTGCTGCGTAACGATCCCGAAGGCGTCGCCGCCAACCTGGCGCGGCGCGGATTCGAATTCGATGC
GGCCGGCTACCGGGCGTTGGATGCTCGGCGGCGTGACCTTCAGCAGGAGACGCAGACCCTGCAGAACCAGCGCAACGAGC
GCTCCAAGGAGATCGGAGCGGCCAAGAAGCGCGGTGAGGACATCGAGCCGCTGAAGGCGGAGGTGGGTCGCATCGCCGAG
CGGCTGAGCGAGGCCGAAACGGCCCTGAACGAAGTGCAGGAGCAGCTCGATGAGCTGCATCTGGGCCTGCCCAATCTGCT
CGATGAGCAGGTCCCCGATGGTCAGGACGAGGAAGACAACCGCGTACTTCGCCAGTGGGGCGGGATCCCGGCACTGTCCT
TCAAGCCGCGGGATCACGTCGACCTCGGCGAGCTGCTGGGCGGGATGGATTTTGAGGCCGCCGCGCGTATTGCCGGGAGC
CGCTTCGTCACCCTCAGCGGCCCGCTGGCGCGTCTGCACCGCGCCCTGACCCAGTTCATGCTCGACCTGCACTGCCGGGA
GCACGGCTACACCGAGGTCTATGTCCCGTATCTGGTCAATGCCCGCTCCCTGACCGGTACCGGGCAGCTACCCAAGTTCG
AGGACGACCTGTTTCGCGTCGAGCACGATCCGAGCCTTTATCTCGCCCCGACGGCCGAGGTGCCGGTGACCAACCTGGTC
CAGGAGCGGATCGTCGAGGACGCCGACATGCCGTTGCGTTTCGTCTGCCATACGCCGTGCTTTCGCTCCGAGGCCGGCAG
CTACGGCAAGGACACGCGCGGCATGATCCGTCAGCACCAGTTCGAGAAGGTCGAGCTGGTGCAGGTCGTGCGCCCCGGCG
AGTCCTGGGATGCCCTGGAGGCTCTCACCGGCCACGCCGAGACCGTACTGCGCCGCTTGGCGCTGCCCTACCGGGTGGTC
TCGCTGTGTGGCGGGGACATCGGCTTCTCGGCGGCGCGCACCTACGACCTGGAGGTGTGGCTGCCCGCCCAGGAGCGCTA
CCGCGAGATCTCCTCCTGCTCGAACTTCACCGACTTCCAGGCCCGCCGACTGCAGGCGCGCTGGCGCAATCCGGAGACCG
GCAAGCCGGAGCCCGTGCACACCCTCAACGGCTCCGGACTGGCGGTGGGCCGCTGCCTGGTGGCGATCCTGGAGAACTAT
CAGGAGGCCGACGGCCGGGTGAACGTCCCCGAGGCCCTGGTCCCGTACATGGGTGGGCAACGGCTCCTGGGGGACTGA

Upstream 100 bases:

>100_bases
CCGGCAGGGGTGATCGGTGCCGTGGCGCCGACCGCCTGGAAGTCTTTAAAATGCCCGCCGCCCATGGCGCCCGCCCCGGA
ACAAGGAGCCTGCGACACCC

Downstream 100 bases:

>100_bases
GCACCGCGGCGAGCCAACGCCCCGGGCGGACACGCGTCGCTGAATGCTAGGGAGAGGATCTCCGGGATGGAAAGAGGGGG
CCGGGCATCGCGCCCGGCCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIDPKLLRNDPEGVAANLARRGFEFDAAGYRALDARRRDLQQETQTLQNQRNERSKEIGAAKKRGEDIEPLKAEVGRIAE
RLSEAETALNEVQEQLDELHLGLPNLLDEQVPDGQDEEDNRVLRQWGGIPALSFKPRDHVDLGELLGGMDFEAAARIAGS
RFVTLSGPLARLHRALTQFMLDLHCREHGYTEVYVPYLVNARSLTGTGQLPKFEDDLFRVEHDPSLYLAPTAEVPVTNLV
QERIVEDADMPLRFVCHTPCFRSEAGSYGKDTRGMIRQHQFEKVELVQVVRPGESWDALEALTGHAETVLRRLALPYRVV
SLCGGDIGFSAARTYDLEVWLPAQERYREISSCSNFTDFQARRLQARWRNPETGKPEPVHTLNGSGLAVGRCLVAILENY
QEADGRVNVPEALVPYMGGQRLLGD

Sequences:

>Translated_425_residues
MIDPKLLRNDPEGVAANLARRGFEFDAAGYRALDARRRDLQQETQTLQNQRNERSKEIGAAKKRGEDIEPLKAEVGRIAE
RLSEAETALNEVQEQLDELHLGLPNLLDEQVPDGQDEEDNRVLRQWGGIPALSFKPRDHVDLGELLGGMDFEAAARIAGS
RFVTLSGPLARLHRALTQFMLDLHCREHGYTEVYVPYLVNARSLTGTGQLPKFEDDLFRVEHDPSLYLAPTAEVPVTNLV
QERIVEDADMPLRFVCHTPCFRSEAGSYGKDTRGMIRQHQFEKVELVQVVRPGESWDALEALTGHAETVLRRLALPYRVV
SLCGGDIGFSAARTYDLEVWLPAQERYREISSCSNFTDFQARRLQARWRNPETGKPEPVHTLNGSGLAVGRCLVAILENY
QEADGRVNVPEALVPYMGGQRLLGD
>Mature_425_residues
MIDPKLLRNDPEGVAANLARRGFEFDAAGYRALDARRRDLQQETQTLQNQRNERSKEIGAAKKRGEDIEPLKAEVGRIAE
RLSEAETALNEVQEQLDELHLGLPNLLDEQVPDGQDEEDNRVLRQWGGIPALSFKPRDHVDLGELLGGMDFEAAARIAGS
RFVTLSGPLARLHRALTQFMLDLHCREHGYTEVYVPYLVNARSLTGTGQLPKFEDDLFRVEHDPSLYLAPTAEVPVTNLV
QERIVEDADMPLRFVCHTPCFRSEAGSYGKDTRGMIRQHQFEKVELVQVVRPGESWDALEALTGHAETVLRRLALPYRVV
SLCGGDIGFSAARTYDLEVWLPAQERYREISSCSNFTDFQARRLQARWRNPETGKPEPVHTLNGSGLAVGRCLVAILENY
QEADGRVNVPEALVPYMGGQRLLGD

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=337, Percent_Identity=37.6854599406528, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI8923421, Length=430, Percent_Identity=32.7906976744186, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI225579074, Length=441, Percent_Identity=31.9727891156463, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=58.6046511627907, Blast_Score=519, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17539260, Length=426, Percent_Identity=32.1596244131455, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=361, Percent_Identity=27.9778393351801, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=397, Percent_Identity=33.5012594458438, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=399, Percent_Identity=30.8270676691729, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24581334, Length=430, Percent_Identity=31.8604651162791, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17737985, Length=288, Percent_Identity=30.2083333333333, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_HALHL (A1WWU7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002961.1
- ProteinModelPortal:   A1WWU7
- SMR:   A1WWU7
- STRING:   A1WWU7
- GeneID:   4711162
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1392
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   A1WWU7
- ProtClustDB:   PRK05431
- BioCyc:   HHAL349124:HHAL_1392-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47719; Mature: 47719

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPKLLRNDPEGVAANLARRGFEFDAAGYRALDARRRDLQQETQTLQNQRNERSKEIGA
CCCCHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKRGEDIEPLKAEVGRIAERLSEAETALNEVQEQLDELHLGLPNLLDEQVPDGQDEEDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHH
RVLRQWGGIPALSFKPRDHVDLGELLGGMDFEAAARIAGSRFVTLSGPLARLHRALTQFM
HHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LDLHCREHGYTEVYVPYLVNARSLTGTGQLPKFEDDLFRVEHDPSLYLAPTAEVPVTNLV
HHHHHHHCCCCEEEHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCEEEECCCCCCHHHHH
QERIVEDADMPLRFVCHTPCFRSEAGSYGKDTRGMIRQHQFEKVELVQVVRPGESWDALE
HHHHHHCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALTGHAETVLRRLALPYRVVSLCGGDIGFSAARTYDLEVWLPAQERYREISSCSNFTDFQ
HHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCHHHH
ARRLQARWRNPETGKPEPVHTLNGSGLAVGRCLVAILENYQEADGRVNVPEALVPYMGGQ
HHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
RLLGD
CCCCC
>Mature Secondary Structure
MIDPKLLRNDPEGVAANLARRGFEFDAAGYRALDARRRDLQQETQTLQNQRNERSKEIGA
CCCCHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKRGEDIEPLKAEVGRIAERLSEAETALNEVQEQLDELHLGLPNLLDEQVPDGQDEEDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHH
RVLRQWGGIPALSFKPRDHVDLGELLGGMDFEAAARIAGSRFVTLSGPLARLHRALTQFM
HHHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LDLHCREHGYTEVYVPYLVNARSLTGTGQLPKFEDDLFRVEHDPSLYLAPTAEVPVTNLV
HHHHHHHCCCCEEEHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCEEEECCCCCCHHHHH
QERIVEDADMPLRFVCHTPCFRSEAGSYGKDTRGMIRQHQFEKVELVQVVRPGESWDALE
HHHHHHCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALTGHAETVLRRLALPYRVVSLCGGDIGFSAARTYDLEVWLPAQERYREISSCSNFTDFQ
HHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCHHHH
ARRLQARWRNPETGKPEPVHTLNGSGLAVGRCLVAILENYQEADGRVNVPEALVPYMGGQ
HHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
RLLGD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA