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The map label for this gene is kdsB

Identifier: 121998034

GI number: 121998034

Start: 1350504

End: 1351277

Strand: Reverse

Name: kdsB

Synonym: Hhal_1244

Alternate gene names: 121998034

Gene position: 1351277-1350504 (Counterclockwise)

Preceding gene: 121998035

Following gene: 121998033

Centisome position: 50.45

GC content: 70.16

Gene sequence:

>774_bases
ATGAGCACGCCGGCATTCACTGTGGTCATCCCGGCGCGGTACGGAGCCTCGCGGCTGCCGGGCAAGCCGCTGGCCGATCT
GCTCGGCGAGCCGGTGGTCCAGCACGTCTACCGGCGCGCGGTAGAGAGCGGCGCCGCCCGGGTGGTCGTGGCGACCGACG
ACGCGCGGATCGAGTCGGCCTGTCGCGATTTCGGGGCGGAGGTCTTGCTGACCGCCCCCGACCATCCCACGGGGACCGAT
CGCATCGCCGAGGTGGTCGATCGTCTGGCATTGGTTGACGAGGCTATCGTGGTGAACCTGCAAGGCGACGAGCCGCTGAT
GCCCCCGGAGCTGGTCGCACTGGTGGCCGAGCGGCTCGATACGGATCCGGACGCGGCCATTGCCACTCTGGCGACCCCGG
TCACCGCCGCGGACGAGCTCTTCGAACCGTCGGTCGTCAAGGTAGTGCGCGATCACCGTGACCACGCCCTCTACTTCAGC
CGCGCGCCGGTCCCCTGGGACCGGGACCGCTTCGACGGGATCGATGATGGCGCCGTCGCTGCGGGGGGCTGGCTCCGCCA
CCTAGGACTCTACGCCTACCGGGCCGCCTTCCTTCGCCGTTTCCCGGGGCTCGAGCCGGCTCCGCCAGAGCGGCTGGAGT
CTCTGGAACAGTTGCGAGCGCTATGGCACGGTTTCGCGATCCAGGTGGCCGCCACCGACCAGCGCCCGGGGCCGGGTGTC
GATACGCCGGCCGATCTCGAGGCGGTAGCCCGGCGGCTGCAATCAACCCGATAA

Upstream 100 bases:

>100_bases
ACCGGCTCTGGTACCTGCCTGTCGAGTTGGAACCGGGATGCGAGTTGACTGCCGCGGTGTCCGGGCTGCTGACTCGGCTG
CACGCCCGGGAGGGCCGGGT

Downstream 100 bases:

>100_bases
GGAAATGGTGTTATGTCCGAGGACAAACTGCGTGTGCTGCTCGTCTGCATGGGCAATATCTGTCGATCGCCAACGGCGGA
GGGTGTGCTGCGCCAACGCC

Product: 3-deoxy-D-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSTPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESACRDFGAEVLLTAPDHPTGTD
RIAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLDTDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFS
RAPVPWDRDRFDGIDDGAVAAGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGV
DTPADLEAVARRLQSTR

Sequences:

>Translated_257_residues
MSTPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESACRDFGAEVLLTAPDHPTGTD
RIAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLDTDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFS
RAPVPWDRDRFDGIDDGAVAAGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGV
DTPADLEAVARRLQSTR
>Mature_256_residues
STPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESACRDFGAEVLLTAPDHPTGTDR
IAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLDTDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFSR
APVPWDRDRFDGIDDGAVAAGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGVD
TPADLEAVARRLQSTR

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=246, Percent_Identity=50.4065040650407, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_HALHL (A1WWF7)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002821.1
- ProteinModelPortal:   A1WWF7
- SMR:   A1WWF7
- STRING:   A1WWF7
- GeneID:   4710478
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1244
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   FSRAPLP
- PhylomeDB:   A1WWF7
- ProtClustDB:   CLSK727393
- BioCyc:   HHAL349124:HHAL_1244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27872; Mature: 27741

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESA
CCCCCEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
CRDFGAEVLLTAPDHPTGTDRIAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLD
HHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHC
TDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFSRAPVPWDRDRFDGIDDGAVA
CCCCHHHHHHHCCHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHH
AGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
DTPADLEAVARRLQSTR
CCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
STPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESA
CCCCEEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHH
CRDFGAEVLLTAPDHPTGTDRIAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLD
HHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHC
TDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFSRAPVPWDRDRFDGIDDGAVA
CCCCHHHHHHHCCHHHHHHHHCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHH
AGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
DTPADLEAVARRLQSTR
CCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA