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The map label for this gene is lpxK

Identifier: 121998035

GI number: 121998035

Start: 1351274

End: 1352257

Strand: Reverse

Name: lpxK

Synonym: Hhal_1245

Alternate gene names: 121998035

Gene position: 1352257-1351274 (Counterclockwise)

Preceding gene: 121998036

Following gene: 121998034

Centisome position: 50.49

GC content: 69.61

Gene sequence:

>984_bases
GTGTCAGTCCCGGGGTTCTGGCTTGAGGATGGTCTGCCGGCGCGGGCGCTCGCCCCGCTCGCGGCCCTCTACGGGGCGGG
CGTAGTGCTGCGCCGGGGGCTTTATCAGCGCGGCTGGTTGCACCGTCCGGCGTCCCCGGTGCCGGTGATCGTCGTCGGCA
ACCTTTTTGTGGGCGGCACCGGCAAGACCCCCCTGGTGGCGTGGCTGGTCACCCAGCTGCGTGAATACGGGTGGCACCCA
GCCATCGTCGCCCGTGGCTACGGCGGCCGGGCGGGGAAGGGGCCGGTGGCGGTGACCGCCGACTCGGATCCGGCCGACTC
GGGGGATGAACCGCTCCTGCTCGCCCGGCGCTGCGCTGTGCCGGTGTTCGTCGGCAGTGATCGTCCGGCCACCGTCCAGG
CTGCCTACCAGGCCGGCTGCGACGTGGTGGTCAGTGACGACGGCTTGCAGCACTACCGGATGCGCCGGGACGCGGAGATC
GTGGTCCTCGACGCGCATCGACGATTGGGCAATCGGCGACTGCTGCCAGCCGGGCCACTGCGTGAGCCGATCGGGCGCCT
GGCTGGCGTGGATATCGTCGCCGTCAATGGGGACGCGGTCCCGGAAGGGGATTGTGTATTCCATCTGCAACCGGGCGCAC
CGCGGGCCGTAGACGGGAGCCAGCGGCCCTGGCCGGGCGGGGAAGCCCACGCCGTCGCCGGCATCGGTCATCCCGAGCGG
TTCTTTGCCTCCCTGCAGGAGGTCGGGATCGGTGTGGCGGAACGCCACGTTTTCCCGGATCATCACGCCTATTCCTCCCA
GGATCTTTCCTTCGCTGACGAGCGACCGATCATCATGACCGAGAAGGATGCGGTGAAGTGCCGTGATCTCCCGCAGGCGG
ACCGGCTCTGGTACCTGCCTGTCGAGTTGGAACCGGGATGCGAGTTGACTGCCGCGGTGTCCGGGCTGCTGACTCGGCTG
CACGCCCGGGAGGGCCGGGTATGA

Upstream 100 bases:

>100_bases
GGGACGCACCGCGAACTGCTGGATCGGGGAGGGCGCTACGCTGGCCTCTACCGCATGCAGTTCGAAGACCGGTCCGAGCC
GCAGTCGGAGGGGTAGGCGG

Downstream 100 bases:

>100_bases
GCACGCCGGCATTCACTGTGGTCATCCCGGCGCGGTACGGAGCCTCGCGGCTGCCGGGCAAGCCGCTGGCCGATCTGCTC
GGCGAGCCGGTGGTCCAGCA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSVPGFWLEDGLPARALAPLAALYGAGVVLRRGLYQRGWLHRPASPVPVIVVGNLFVGGTGKTPLVAWLVTQLREYGWHP
AIVARGYGGRAGKGPVAVTADSDPADSGDEPLLLARRCAVPVFVGSDRPATVQAAYQAGCDVVVSDDGLQHYRMRRDAEI
VVLDAHRRLGNRRLLPAGPLREPIGRLAGVDIVAVNGDAVPEGDCVFHLQPGAPRAVDGSQRPWPGGEAHAVAGIGHPER
FFASLQEVGIGVAERHVFPDHHAYSSQDLSFADERPIIMTEKDAVKCRDLPQADRLWYLPVELEPGCELTAAVSGLLTRL
HAREGRV

Sequences:

>Translated_327_residues
MSVPGFWLEDGLPARALAPLAALYGAGVVLRRGLYQRGWLHRPASPVPVIVVGNLFVGGTGKTPLVAWLVTQLREYGWHP
AIVARGYGGRAGKGPVAVTADSDPADSGDEPLLLARRCAVPVFVGSDRPATVQAAYQAGCDVVVSDDGLQHYRMRRDAEI
VVLDAHRRLGNRRLLPAGPLREPIGRLAGVDIVAVNGDAVPEGDCVFHLQPGAPRAVDGSQRPWPGGEAHAVAGIGHPER
FFASLQEVGIGVAERHVFPDHHAYSSQDLSFADERPIIMTEKDAVKCRDLPQADRLWYLPVELEPGCELTAAVSGLLTRL
HAREGRV
>Mature_326_residues
SVPGFWLEDGLPARALAPLAALYGAGVVLRRGLYQRGWLHRPASPVPVIVVGNLFVGGTGKTPLVAWLVTQLREYGWHPA
IVARGYGGRAGKGPVAVTADSDPADSGDEPLLLARRCAVPVFVGSDRPATVQAAYQAGCDVVVSDDGLQHYRMRRDAEIV
VLDAHRRLGNRRLLPAGPLREPIGRLAGVDIVAVNGDAVPEGDCVFHLQPGAPRAVDGSQRPWPGGEAHAVAGIGHPERF
FASLQEVGIGVAERHVFPDHHAYSSQDLSFADERPIIMTEKDAVKCRDLPQADRLWYLPVELEPGCELTAAVSGLLTRLH
AREGRV

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=312, Percent_Identity=42.9487179487179, Blast_Score=217, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_HALHL (A1WWF8)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002822.1
- STRING:   A1WWF8
- GeneID:   4710479
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1245
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   A1WWF8
- ProtClustDB:   PRK00652
- BioCyc:   HHAL349124:HHAL_1245-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35092; Mature: 34961

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPGFWLEDGLPARALAPLAALYGAGVVLRRGLYQRGWLHRPASPVPVIVVGNLFVGGT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEECCC
GKTPLVAWLVTQLREYGWHPAIVARGYGGRAGKGPVAVTADSDPADSGDEPLLLARRCAV
CCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEHHHCCC
PVFVGSDRPATVQAAYQAGCDVVVSDDGLQHYRMRRDAEIVVLDAHRRLGNRRLLPAGPL
EEEECCCCCCEEHHHHHCCCEEEECCCCHHHHHHCCCCEEEEEECHHHCCCCCCCCCCCH
REPIGRLAGVDIVAVNGDAVPEGDCVFHLQPGAPRAVDGSQRPWPGGEAHAVAGIGHPER
HHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FFASLQEVGIGVAERHVFPDHHAYSSQDLSFADERPIIMTEKDAVKCRDLPQADRLWYLP
HHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCEEEEE
VELEPGCELTAAVSGLLTRLHAREGRV
EEECCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVPGFWLEDGLPARALAPLAALYGAGVVLRRGLYQRGWLHRPASPVPVIVVGNLFVGGT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEECCC
GKTPLVAWLVTQLREYGWHPAIVARGYGGRAGKGPVAVTADSDPADSGDEPLLLARRCAV
CCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCEEEHHHCCC
PVFVGSDRPATVQAAYQAGCDVVVSDDGLQHYRMRRDAEIVVLDAHRRLGNRRLLPAGPL
EEEECCCCCCEEHHHHHCCCEEEECCCCHHHHHHCCCCEEEEEECHHHCCCCCCCCCCCH
REPIGRLAGVDIVAVNGDAVPEGDCVFHLQPGAPRAVDGSQRPWPGGEAHAVAGIGHPER
HHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FFASLQEVGIGVAERHVFPDHHAYSSQDLSFADERPIIMTEKDAVKCRDLPQADRLWYLP
HHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCEEEEE
VELEPGCELTAAVSGLLTRLHAREGRV
EEECCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA